 | | Vol. 15.12 – 2 April, 2024 |
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| Researchers established a long-term microplastics (MPs) intake mouse model and found that MPs caused severe damage to the hematopoietic system.
[Cell Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified the hepatokine fibrinogen-like 1 (FGL1) as a previously undescribed suppressor of hepcidin that was induced in the liver in response to hypoxia during the recovery from anemia, and in thalassemic mice.
[Blood] |
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| Researchers found that Yin Yang 1 (YY1) physically interacted with structural maintenance of chromosomes 3 (SMC3) and co-occupied with SMC3 at a large cohort of promoters genome-wide, and YY1 deficiency deregulated the genetic network governing cell metabolism.
[Blood Advances] |
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| Peripheral blood samples from patients with sickle cell disease before and after red blood cell transfusions were probed for neutrophil and monocyte activation markers and analyzed by fluorescence-activated cell sorting.
[Blood Advances] |
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| The authors studied transcriptomic effects of four patient-derived growth factor independence 1B (GFI1B) variants in MEG01 megakaryoblasts. Compared to normal GFI1B, each variant affected different gene programs with GFI1BQ287* uniquely failing to repress myeloid traits.
[Communications Biology] |
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| Scientists developed a biosensing architecture built on red blood cell membrane proteins that were retained through erythropoiesis.
[ACS Synthetic Biology] |
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| Investigators used two national biobank cohorts comprised of >650,000 participants with linked genomic and longitudinal phenotypic data to describe the features of clonal hematopoiesis of indeterminate potential across 2,610 individuals who received kidney, liver, heart, or lung allografts.
[Clinical Cancer Research] |
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| The authors demonstrated that mitochondria-associated lactate dehydrogenase allowed AML myeloblasts to utilize lactate as a metabolic bypass to fuel mitochondrial respiration and maintain cellular viability.
[Cancer Research] |
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| Scientists presented a rare instance of pure red cell aplasia occurring after ABO-matched allo-HSCT in a refractory/relapsed acute myeloid leukemia patient.
[Annals Of Hematology] |
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| The authors present an overview of delivery vectors or direct intervention agents for leukemia therapy, describing their physicochemical properties, their role in leukemia treatment, and the challenges they face in the context of clinical translation.
[Advanced Materials] |
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| Syndax Pharmaceuticals announced that the US FDA has granted Priority Review for its New Drug Application (NDA) for revumenib for the treatment of adult and pediatric relapsed or refractory KMT2A-rearranged acute leukemia.
[Syndax Pharmaceuticals] |
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| May 2 – 3, 2024
Helsingør, Denmark |
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| | Lund University – Lund, Sweden |
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| | Cedars-Sinai – Los Angeles , California, United States |
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| | University of Virginia – Charlottesville , Virginia, United States |
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| | Universitätsklinikum Köln – Cologne, Germany |
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| | Francis Crick Institute – London, England, United Kingdom |
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Cancer Stem Cell News
Cell Therapy News
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