Hematopoiesis News Volume 15.13 | Apr 9 2024

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    Noshin Noorjahan
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    2024-04-09 | HN 15.13


    Hematopoiesis News by STEMCELL Technologies
    Vol. 15.13 – 9 April, 2024
    TOP STORY

    Lineage-Tracing Hematopoietic Stem Cell Origins In Vivo to Efficiently Make Human HLF+ HOXA+ Hematopoietic Progenitors from Pluripotent Stem Cells

    Guided by the arterial origins of blood, the authors efficiently and rapidly differentiate human pluripotent stem cells into posterior primitive streak, lateral mesoderm, artery endothelium, hemogenic endothelium, and >90% pure hematopoietic progenitors within ten days.
    [Developmental Cell]

    Full ArticleGraphical Abstract
    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Early-Wave Macrophages Control Late Hematopoiesis

    Investigators showed that loss of early-wave macrophages in Drosophila and mice accelerated late hematopoiesis, which did not correlate with inflammation and did not rely on macrophage phagocytic ability.
    [Developmental Cell]

    AbstractGraphical Abstract

    Proteinase 3 Depletion Attenuates Leukemia by Promoting Myeloid Differentiation

    Researchers showed that the genetic elimination of proteinase 3 (PRTN3) in mice led to spontaneous myeloid differentiation. Mechanistically, their findings indicated that PRTN3 interacted with the N-terminal of STAT3, serving as a negative regulator of STAT3-dependent myeloid differentiation.
    [Cell Death & Differentiation]

    Full Article

    Hematopoiesis Post Anti-CD117 Monoclonal Antibody Treatment in Wild-Type and Fanconi Anemia Settings

    Scientists conducted rigorous assessments to evaluate the effects of antagonistic anti-mCD117 monoclonal antibody, ACK2, on hematopoiesis in wild-type and Fanconi Anemia mice.
    [Haematologica]

    Abstract

    Circadian Disturbances by Altering the Light–Dark Cycle Negatively Affects Hematopoietic Function of Bone Marrow in Mice

    The authors exposed C57bl/6j mice to repeated reversed light–dark cycles for 90 days to research the effects of circadian disturbance on bone marrow hematopoietic function.
    [FASEB Journal]

    Abstract

    Pre-Frailty after Blood or Marrow Transplantation and the Risk of Subsequent Mortality

    Investigators examined the prevalence, risk factors, and association between pre-frailty and subsequent mortality after blood or marrow transplantation.
    [Leukemia]

    Full Article

    HES6 Knockdown in Human Hematopoietic Precursor Cells Reduces Their In Vivo Engraftment Potential and Their Capacity to Differentiate into Erythroid Cells, B Cells, T Cells, and Plasmacytoid Dendritic Cells

    The authors investigated the role of Hairy/Enhancer of Split (HES) 6 in human hematopoiesis using in vitro and in vivo models.
    [Haematologica]

    Abstract

    Altered Platelet-Megakaryocyte Endocytosis and Trafficking of Albumin and Fibrinogen in RUNX1 Haplodeficiency

    Researchers showed that platelet endocytosis of fluorescent-labeled albumin, fibrinogen, and IgG was decreased in a patient and his daughter with familial platelet defect with predisposition to myeloid malignancy.
    [Blood Advances]

    Full Article
    Graphical Abstract

    Optimized BEAC Conditioning Regimen Improves Clinical Outcomes of Autologous Hematopoietic Stem Cell Transplantation in Non-Hodgkin Lymphomas

    Scientists explored the efficacy and safety of an optimized BEAC (adjusted-dose, intermediate-dose cytarabine and reduced-dose cyclophosphamide, AD-BEAC) conditioning regimen for non-Hodgkin lymphoma.
    [International Journal of Hematology]

    Full Article
    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    REVIEWS

    Essential Thrombocythaemia: A Contemporary Approach with New Drugs on the Horizon

    Investigators focus on the evolving landscape of treatment strategies in essential thrombocythemia, with an emphasis on the role of molecular profiling in guiding therapeutic decisions.
    [British Journal of Haematology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Syros Receives Fast Track Designation from the FDA for Tamibarotene for the Treatment of Newly Diagnosed Unfit AML with RARA Gene Overexpression

    Syros Pharmaceuticals announced that the US FDA has granted Fast Track Designation to tamibarotene in combination with azacitidine and venetoclax for the treatment of newly diagnosed AML with RARA overexpression.
    [Syros Pharmaceuticals]

    Press Release
    FEATURED EVENT

    Cell Symposia: Exercise Metabolism

    May 5 – 7, 2023
    Lisbon, Portugal

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    JOB OPPORTUNITIES

    Staff Scientist – Myeloid Cell Regulation, Cancer, and Immunotherapy

    Wistar Institute – Philadelphia, Pennsylvania, United States

    Doctoral Position – Hematopoiesis

    Ospedale San Raffaele – Milan, Italy

    Postdoctoral Research Associate – Biochemistry and Molecular Genetics

    University of Virginia – Charlottesville , Virginia, United States

    Postdoctoral Fellow – Cancer Bioinformatics

    Universitätsklinikum Köln – Cologne, Germany

    PhD Position – Translational Immune-Oncology in Blood Cancers

    Georg-Speyer-Haus – Frankfurt, Germany

    > See All Jobs

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