 | | Vol. 15.14 – 16 April, 2024 |
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| Investigators determined whether clonal hematopoiesis of indeterminate potential was associated with atrial fibrillation, inflammatory and cardiac biomarkers, and cardiac structural changes.
[JAMA Cardiology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that GM-CSF programmmed myeloid committed progenitors to produce trained macrophages but programmed the upstream non-committed LKS+ progenitors to produce tolerized macrophages.
[Blood] |
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| The authors revealed that tissue scale signaling regulation could arise from local gap-junction mediated cell–cell signaling through the spatiotemporal establishment of an intermediate-scale of transient multicellular communication communities over the course of tissue development.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists revealed that microcephalin (Mcph1)-knockout mice exhibited congenital macrocytic anemia due to impaired terminal erythroid differentiation during fetal development.
[EMBO Reports] |
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| In vitro culture of isolated CD34+, common myeloid progenitors, and CD34+ CD371– hematopoietic stem progenitor cells were performed to assay the differentiation potential of monocytes, neutrophils, and erythrocytes.
[Stem Cell Research & Therapy] |
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| Scientists studied the effect and mechanism of hypoxia on erythroid differentiation of K562 cells and observed the effect of hypoxia on early erythropoiesis of zebrafish.
[Antioxidants & Redox Signaling] |
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| Researchers treated recovered sham and cecal ligation and puncture mice with a mobilizing regimen of granulocyte colony-stimulating factor (G-CSF) at day 20 post-surgery.
[Stem Cell Reports] |
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| The authors investigated the function of DMT1 isoform lacking the iron-response element in normal and malignant hematopoiesis.
[FEBS Letters] |
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| | Investigators performed targeted sequencing, high-throughput drug screening, and single-cell genomic profiling on leukemia cell samples derived from patients with AML.
[Clinical Cancer Research] |
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| In this randomized controlled feasibility trial conducted in seven hospitals in Australia and New Zealand, scientists enrolled patients with secondary hypogammaglobulinemia with either a history of recurrent/severe infection or an immunoglobulin G level less than 4 g/L.
[Blood Advances] |
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| The authors review the eminent role of reactive oxygen species in the hematological niche and their profound influence on the progress of myelodysplastic syndromes.
[Cellular & Molecular Biology Letters] |
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| Innate Pharma SA announced that the first patient was dosed in the Phase II dose expansion part of the Sanofi-sponsored clinical trial of SAR443579 / IPH6101, evaluating SAR443579 as a monotherapy for the treatment of blood cancers with high unmet needs.
[Innate Pharma] |
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| The University of Sheffield was given more than £2.5m funding to look into dormant cancer cells and develop new treatments for myeloma, a type of blood cancer.
[BBC] |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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| | Harvard University – Cambridge, Massachusetts, United States |
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| | Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | Ospedale San Raffaele – Milan, Italy |
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| | University of Virginia – Charlottesville , Virginia, United States |
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