Hematopoiesis News Volume 15.15 | Apr 23 2024

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    Noshin Noorjahan
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    2024-04-23 | HN 15.15


    Hematopoiesis News by STEMCELL Technologies
    Vol. 15.15 – 23 April, 2024
    TOP STORY

    Mitochondrial tRNA Pseudouridylation Governs Erythropoiesis

    Researchers investigated the role of tRNA pseudouridylation in erythropoiesis and its association with mitochondrial myopathy, lactic acidosis, and sideroblastic anemia syndrome pathogenesis.
    [Blood]

    Abstract
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    Integrative Single-Cell Chromatin and Transcriptome Analysis of Human Plasma Cell Differentiation

    Scientists combined single cell RNA-seq and single cell ATAC-seq to decipher the trajectories involved in plasma cell differentiation.
    [Blood]

    Abstract

    Tyrosine Phosphorylation of CARM1 Promotes Its Enzymatic Activity and Alters Its Target Specificity

    The authors showed that the hyperactivation of Janus kinase 2 by the V617F mutation phosphorylated tyrosine residues in coactivator-associated arginine methyltransferase 1 (CARM1), an important target in hematologic malignancies, increasing its methyltransferase activity and altering its target specificity.
    [Nature Communications]

    Full Article

    Clinical Associations with a Polygenic Predisposition to Benign Lower White Blood Cell Counts

    Researchers investigated the clinical consequences of a genetic predisposition toward lower white blood cell (WBC) counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count comprising single nucleotide polymorphisms not associated with disease.
    [Nature Communications]

    Full Article

    SUCLG1 Restricts POLRMT Succinylation to Enhance Mitochondrial Biogenesis and Leukemia Progression

    Investigators reported that expression of tricarboxylic acid cycle enzyme succinate-CoA ligase SUCLG1 strongly correlated with electron transport chain genes across various TCGA cancer transcriptomes.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    PML::RARA and GATA2 Proteins Interact via DNA Templates to Induce Aberrant Self-Renewal in Mouse and Human Hematopoietic Cells

    Researchers defined the genomic binding sites of PML::RARA in primary mouse and human hematopoietic progenitor cells with V5-tagged PML::RARA, using anti-V5-PML::RARA chromatin immunoprecipitation sequencing and CUT&RUN approaches.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    Caspase 8 Deletion Causes Infection/Inflammation-Induced Bone Marrow Failure and MDS-Like Disease in Mice

    Caspase 8 (Casp8) is a master regulator of pyroptosis, apoptosis, and necroptosis (PANoptosis). To study the role of PANoptosis in hematopoiesis, scientists generated inducible Casp8 knockout mice.
    [Cell Death & Disease]

    Full ArticleGraphical Abstract

    Recipient Clonal Hematopoiesis in Allogeneic Bone Marrow Transplantation for Lymphoid Malignancies

    In this retrospective study, allogeneic blood and marrow transplantation (alloBMT) recipients age 60 and older with lymphoid malignancies were included. Among 97 consecutive patients who received alloBMT between 2017 and 2022, cloal hematopoiesis was detected in 60.
    [Blood Advances]

    Abstract

    SMS121, a New Inhibitor of CD36, Impairs Fatty Acid Uptake and Viability of Acute Myeloid Leukemia

    A drug-like small molecule, SMS121, was identified by receptor-based virtual screening and experimentally demonstrated to target the lipid uptake protein CD36.
    [Scientific Reports]

    Full Article

    miR-214 Aggravates Oxidative Stress in Thalassemic Erythroid Cells by Targeting ATF4

    To understand how miR-214 aggravated oxidative stress in thalassemia erythroid cells, the authors investigated the molecular mechanism of miR-214 and its regulation of the oxidative status in thalassemia erythrocytes.
    [PLOS One]

    Full Article
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    REVIEWS

    Of Gains and Losses: SAMD9/SAMD9L and Monosomy 7 in Myelodysplastic Syndrome

    Germline gain-of function (GOF) SAMD9/SAMD9L mutations cause different syndromes with predisposition to myeloid neoplasms in the young. Primary somatic compensation mutations in the blood are very frequent in patients with germline GOF SAMD9/SAMD9L-related diseases.
    [Experimental Hematology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Robert Zeiser Receives DKMS Mechtild Harf Science Award

    The DKMS Stiftung Leben Spenden has honoured CIBSS member Prof. Dr Robert Zeiser for his outstanding research work in the field of allogeneic stem cell transplantation.
    [CIBSS – Centre for Integrative Biological Signalling Studies]

    Press Release
    FEATURED EVENT

    Cancer and Aging – The Inflammaging Connection

    May 20, 2024
    New York, New York, United States & Online

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    JOB OPPORTUNITIES

    Research Assistant – Bioinformatics, Computational Biology, & Systems Immunology

    University of Duisburg-Essen – Duisburg-Essen, Germany

    Postdoctoral Research Associate – Biology of B Cells and Pathogenesis of Lymphomas and Leukemias

    University of Duisburg-Essen – Duisburg-Essen, Germany

    Postdoctoral Research Associate – Tissue Injury

    University of Illinois at Chicago – Chicago, Illinois, United States

    Staff Scientist – Myeloid Cell Regulation, Cancer, and Immunotherapy

    Wistar Institute – Philadelphia, Pennsylvania, United States

    Doctoral Position – Hematopoiesis

    Ospedale San Raffaele – Milan, Italy

    > See All Jobs

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