LABORATORY RESEARCH The SKP2 E3 Ligase Regulates Basal Homeostasis and Stress-Induced Regeneration of Hematopoietic Stem Cells Investigators showed that SKP2 expression is increased in hematopoietic stem cells and progenitors in response to hematopoietic stress from myelosuppression or following transplantation. [Blood] Identification and Characterization of a Novel Transcriptional Target of RUNX1/AML1 at the Onset of Hematopoietic Development Using microarrays, scientists identified the uncharacterized gene AI467606 as a gene whose expression level is dramatically reduced in the absence of RUNX1. [Blood] Three Chemokine Receptors Cooperatively Regulate Homing of Hematopoietic Progenitors to the Embryonic Mouse Thymus Researchers showed that chemotaxis is the key mechanism regulating thymus homing in the mouse embryo. [Proc Natl Acad Sci U S A] Rapid Mobilization of Hematopoietic Progenitors by AMD3100 and Catecholamines Is Mediated by CXCR4-Dependent SDF-1 Release from Bone Marrow Stromal Cells Investigators reported that AMD3100 increased the homeostatic release of the chemokine stromal cell derived factor-1 (SDF-1) to the circulation in mice and non-human primates. [Leukemia] Hematopoietic Differentiation of Umbilical Cord Blood-Derived Very Small Embryonic/Epiblast-Like Stem Cells Data suggest that umbilical cord blood (UCB)-very small embryonic/epiblast-like stem cells correspond to the most primitive population of hematopoietic stem/progenitor cells in UCB. [Leukemia] Impact of TET2 Mutations on Response Rate to Azacitidine in Myelodysplastic Syndromes and Low Blast Count Acute Myeloid Leukemias Scientists sequenced the TET2 gene in 86 MDS and acute myeloid leukemia with 20–30% blasts treated by azacitidine. [Leukemia] IRF8 Regulates Acid Ceramidase Expression to Mediate Apoptosis and Suppresses Myelogeneous Leukemia Researchers identified acid ceramidase as a general transcription target of IFN regulatory factor 8 (IRF8). [Cancer Res] CLINICAL RESEARCH Mutational Status of the TP53 Gene as a Predictor of Response and Survival in Patients with Chronic Lymphocytic Leukemia: Results from the LRF CLL4 Trial Researchers aimed to address the frequency and prognostic value of TP53 abnormalities in patients with chronic lymphocytic leukemia in the context of a prospective randomized trial. [J Clin Oncol] Chemoimmunotherapy with Ofatumumab, Fludarabine, and Cyclophosphamide in Previously Untreated Patients with Chronic Lymphocytic Leukemia Investigators conducted an international Phase II trial to evaluate two dose levels of ofatumumab, a human CD20 monoclonal antibody, combined with fludarabine and cyclophosphamide as frontline therapy for chronic lymphocytic leukemia. [Blood] Long-Term Risk for Subsequent Leukemia After Treatment for Childhood Cancer: A Report from the Childhood Cancer Survivor Study This is the first description of a statistically significant increased risk of secondary leukemia more than 15 years from primary diagnosis of childhood cancer. [Blood] Allogeneic Cellular Gene Therapy in Hemoglobinopathies—Evaluation of Hematopoietic SCT in Sickle Cell Anemia Data confirmed SCT from a suitable HLA-matched, related donor should become the primary option for curing children with sickle cell anemia. [Bone Marrow Transplant] |