Hematopoiesis News Volume 3.00 | Jan 3 2012

Blood Progenitor Cells Receive Signals from Niche Cells and the Daughter Blood Cells They Create
In a new discovery, scientists found that the blood progenitor cells receive critical signals back from the daughter blood cells they create, telling the progenitor cells when enough blood cells have been made and it’s time to stop differentiating. [Press release from EurekAlert! discussing online prepublication in Cell]
Press Release | Abstract

LABORATORY RESEARCH

Identification of a Monocyte-Predisposed Hierarchy of Hematopoietic Progenitor Cells in the Adventitia of Postnatal Murine Aorta
Here, scientists hypothesized that the arterial wall is a source of hematopoietic progenitor cells and hematopoietic stem cells in postnatal life. [Circulation] Abstract

PI3Kδ Inhibitor, GS-1101 (CAL-101), Attenuates Pathway Signaling, Induces Apoptosis, and Overcomes Signals from the Microenvironment in Cellular Models of Hodgkin Lymphoma
To investigate the potential role of PI3Kδ in Hodgkin lymphoma (HL), researchers screened 5 HL cell lines and primary samples from patients with HL for PI3Kδ isoform expression and constitutive PI3K pathway activation. [Blood] Abstract

Genome Wide Analysis of Histone H3 Acetylation Patterns in AML Identifies Peroxiredoxin 2 as an Epigenetically Silenced Tumor Suppressor Gene
Using ChIP-Chip assays in primary leukemia samples, researchers demonstrate that acute myeloid leukemia (AML) blasts exhibit significant alterations in histone H3 acetylation levels at more than 1000 genomic loci compared to CD34⁺ progenitor cells. [Blood] Abstract

Activation of Stress Response Gene SIRT1 by BCR-ABL Promotes Leukemogenesis
Here investigators show that BCR-ABL activates expression of the mammalian stress response gene SIRT1 in hematopoietic progenitor cells, which involves signal transducer and activator of transcription 5 signaling. [Blood] Abstract

Characterization of High-Affinity Peptides and Their Feasibility for Use in Nanotherapeutics Targeting Leukemia Stem Cells
The presence of C-type lectin-like molecule-1 (CLL1)-targeting peptides on surface of the nanomicelles enabled the improved binding and delivery of substantially more daunorubicin into the cells expressing CLL1 and CD34⁺ leukemic cells compared to unmodified nanomicelles. [Nanomedicine] Abstract

Functional Regulation of Pre-B-Cell Leukemia Homeobox Interacting Protein 1 (PBXIP1/HPIP) in Erythroid Differentiation
Here researchers show that lentiviral-mediated overexpression of HPIP in human CD34⁺ cells enhances hematopoietic colony formation in vitro, whereas HPIP knock down led to a reduction in the number of such colonies. [J Biol Chem] Abstract

BPR1J-097, a Novel FLT3 Kinase Inhibitor, Exerts Potent Inhibitory Activity Against Acute Myeloid Leukemia
The effects of inhibition of Fms-like tyrosine kinase 3 (FLT3) activity by a novel potent FLT3 inhibitor, BPR1J-097, were investigated using in vitro and in vivo assays. [Br J Cancer] Abstract

Establishing Rps6 Hemizygous Mice as a Model for Studying How Ribosomal Protein Haploinsufficiency Impairs Erythropoiesis
Here, scientists characterize the hematopoietic phenotype of mice lacking one allele of the ribosomal protein S6 (Rps6) gene. [Exp Hematol] Abstract

Aldehyde Dehydrogenases Are Regulators of Hematopoietic Stem Cell Numbers and B-Cell Development
Researchers find that ALDH1A1 deficiency is associated with increased expression of the ALDH3A1 isoform, suggesting its potential to compensate for ALDH1A1. [Exp Hematol] Abstract

Nicotinamide, a Sirtuin Inhibitor, Inhibits Differentiation and Facilitates Expansion of Hematopoietic Progenitor Cells with Enhanced Bone Marrow Homing and Engraftment
Here investigators report that nicotinamide, a form of vitamine-B3, delayed differentiation and increased engraftment efficacy of cord blood-derived human CD34⁺ cells cultured with cytokines. [Exp Hematol] Abstract

CLINICAL RESEARCH

Prognostic Value of “Monosomal Karyotype” in Comparison to “Complex Aberrant Karyotype” in Acute Myeloid Leukemia: Study on 824 Cases with Aberrant Karyotype
Patients with “monosomal karyotype” or complex karyotype defined as equal or greater than 3, 4 or 5 abnormalities showed an inferior OS compared to the respective remaining patients not fulfilling these criteria (for all p less than 0.001). [Blood] Abstract

TP53 Alterations in Acute Myeloid Leukemia with Complex Karyotype Correlate with Specific Copy Number Alterations, Monosomal Karyotype, and Dismal Outcome
To assess the frequency of TP53 alterations and their correlation with other genetic changes and outcome in acute myeloid leukemia with complex karyotype (CK-AML), researchers performed integrative analysis using TP53 mutational screening and array-based genomic profiling in 234 CK-AML. [Blood] Abstract

The Hematopoietic Cell Transplantation Comorbidity Index Is a Predictor of Early Death and Survival in Adult Acute Myeloid Leukemia Patients
The aim of this study was to determine the prognostic role of the hematopoietic cell transplantation comorbidity index for early death and survival in adult acute myeloid leukemia patients. [Leuk Res] Abstract

Emergent Initiates Phase II Study of TRU-016 in Combination with Bendamustine in Patients with Relapsed Chronic Lymphocytic Leukemia
Emergent BioSolutions Inc. announced the initiation of a Phase II study (protocol 16201) of TRU-016 in combination with bendamustine for patients with relapsed chronic lymphocytic leukemia. [Emergent BioSolutions Inc.] Press Release

Astex Announces FDA ODAC Meeting of sNDA Application for Dacogen in Treatment of Elderly Acute Myelogenous Leukemia
Astex Pharmaceuticals, Inc. announced the pre-publication notice of the Food and Drug Administration (FDA), Oncologic Drugs Advisory Committee (ODAC) Meeting to discuss the supplemental new drug application (sNDA) for Dacogen^® for Injection, an application submitted by Eisai, Inc. [Astex Pharmaceuticals, Inc.] Press Release

Post-Doc Receives Scholar Award from American Society of Hematology
John Anto Pulikkan, PhD, received a 2012 Scholar Award from the American Society of Hematology, the world’s largest professional society concerned with the causes and treatment of blood disorders. [University of Massachusetts Medical School] Press Release

Medical College and BloodCenter Researcher to Study Treatment for Sickle Cell Disease
The Medical College of Wisconsin and BloodCenter of Wisconsin have received a three-year, $486,000 grant from the Doris Duke Charitable Foundation to study a new treatment for sickle cell disease. [Medical College of Wisconsin] Press Release

NIH Establishes National Center for Advancing Translational Sciences
In a move to re-engineer the process of translating scientific discoveries into new drugs, diagnostics, and devices, the National Institutes of Health (NIH) has established the National Center for Advancing Translational Sciences. [National Institutes of Health, United States] Press Release

Agency Information Collection Activities; Proposed Collection; Comment Request; Revisions to Labeling Requirements for Blood and Blood Components, Including Source Plasma [FR Doc No: 2011-33555] [Food and Drug Administration, United States]

Oncologic Drugs Advisory Committee; Notice of Meeting [FR Doc No: 2011-33548] [Food and Drug Administration, United States]

Oncologic Drugs Advisory Committee; Notice of Meeting [FR Doc No: 2011-33552] [Food and Drug Administration, United States]

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Select Biosciences – Circulating Tumor Cells 2012
February 2-3, 2012
San Diego, United States

NEW Gordon Research Conference: DNA Damage, Mutation & Cancer
March 25-30, 2012
Ventura, United States

NEW British Society for Haematology’s 52nd Annual Scientific Meeting
April 16-18, 2012
Glasgow, United Kingdom

Visit our events page to see a complete list of events in the hematopoietic community

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral/Research Associate (Children’s Memorial Research Center)

PhD Research Fellowship, Centre for Molecular Medicine (University of Oslo)

Pediatric Faculty – Hematology/Oncology Stem Cell Sciences (The University of Chicago)

Postdoctoral Research Fellow (Cancer Research UK)

Physician – Hematology/Oncology (Veterans Affairs)

Postdoctoral Positions in Stem Cell Biology (Columbia University)

Professorship in Hematopoietic Stem Cell Transplantation and Head (University of Göttingen)

Postdoctoral Position – Center for Human Genetics (VIB Research Institute)

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