LABORATORY RESEARCH p38 MAPK Inhibition Suppresses the TLR-Hypersensitive Phenotype in FANCC- and FANCA-Deficient Mononuclear Phagocytes Reasoning that suppression of inhibitory cytokine production might enhance hematopoiesis, researchers screened small molecules using TLR-agonist-stimulated FANCC- and FANCA-deficient macrophages containing an NF-kappaB/AP-1 responsive reporter gene. [Blood] Abstract SIRT1 Is Dispensable for Function of Hematopoietic Stem Cells in Adult Mice Herein researchers perform a comprehensive in vivo study of the hematopoietic stem cell (HSC) compartment in adult SIRT1-deficient animals and show that, apart from anemia and leukocytosis in older mice, production of mature blood cells, lineage distribution within hematopoietic organs and frequencies of the most primitive HSC populations are comparable to those of wild type littermate controls. [Blood] Abstract A Human ESC Model for MLL–AF4 Leukemic Fusion Gene Reveals an Impaired Early Hematopoietic-Endothelial Specification This work illustrates how human embryonic stem cells (ESCs) may provide unique insights into human development and further the understanding of how leukemic fusion genes, known to arise prenatally, regulate human embryonic hematopoietic specification. [Cell Res] Abstract GSK3 Is a Regulator of RA Receptor-Mediated Differentiation Here researchers show that the combination of all-trans retinoic acid (ATRA) with GSK3 inhibition significantly enhances ATRA-mediated acute myeloid leukemia differentiation and growth inhibition. [Leukemia] Abstract Bmi1 Is Critical to Prevent Ikaros-Mediated Lymphoid Priming in Hematopoietic Stem Cells Researchers’ results indicate that Ikaros is a critical Bmi1 target in vivo that prevents premature lineage specification of hematopoietic stem cells. [Cell Cycle] Abstract Erythroid-Specific Expression of ß-Globin from Sleeping Beauty-Transduced Human Hematopoietic Progenitor Cells In this study researchers utilized the non-viral sleeping beauty (SB) transposon system using the SB100X hyperactive transposase to transduce human cord blood CD34+ cells with DsRed and a hybrid IHK-ß-globin transgene. [PLoS One] Abstract Role of the Common γ Chain in Cell Cycle Progression of Human Malignant Cell Lines In this study, researchers evaluate whether γ-chain expression could interfere in cell cycle progression in malignant hematopoietic cells. [Int Immunol] Abstract CLINICAL RESEARCH Chronic Phase Chronic Myeloid Leukemia Patients with Low OCT-1 Activity Randomized to High-Dose Imatinib Achieve Better Responses, and Lower Failure Rates, Than Those Randomized to Standard-Dose In this study the predictive value of OCT-1 activity, in the setting of 400 and 800mg/day imatinib dosing, and trough imatinib plasma levels were assessed in 100 patients enrolled to the TOPS study. [Haematologica] Abstract FMS-Like Tyrosine Kinase 3 Internal Tandem Duplication and the Patterns of Its Gene Sequence in 207 Chinese Patients with De Novo Acute Myeloid Leukemia Researchers’ objective was to study the patterns of FMS-like tyrosine kinase 3-internal tandem duplication in Chinese patients with acute myeloid leukemia. [Arch Pathol Lab Med] Abstract Distinctive MicroRNA Signature Is Associated with the Diagnosis and Prognosis of Acute Leukemia Researchers’ results support that microRNA (miR)-128, let-7b, miR-223 and miR181a have a diagnosis value in acute leukemia, while miR-181a and miR-155 are of great prognostic significance in acute myeloid leukemia. [Med Oncol] Abstract |