| PUBLICATIONS (Ranked by impact factor of the journal) | LABORATORY RESEARCH Overexpression of Interleukin 1 Receptor Accessory Protein in Stem and Progenitor Cells and Outcome Correlation in AML and MDS Researchers identified genes dysregulated in stem and progenitor cells in high-risk acute myeloid leukemia (AML), and suggested that interleukin-1 receptor accessory protein may be a promising therapeutic and prognostic target in AML and high-risk myelodysplastic syndrome (MDS). [Blood] Abstract SOCS2 Is Dispensable for BCR/ABL1-Induced Chronic Myeloid Leukemia-Like Disease and for Normal Hematopoietic Stem Cell Function Scientists demonstrated that although suppressor of cytokine signaling 2 (Socs2) was found to be preferentially expressed in long term hematopoietic stem cells (HSCs), Socs2-deficient HSCs were indistinguishable from wild type HSCs when challenged in competitive bone marrow transplantation experiments. [Leukemia] Abstract Focal Adhesion Kinase Splice Variants Maintain Primitive Acute Myeloid Leukemia Cells through Altered Wnt Signaling Targeting focal adhesion kinase (FAK) or ß-catenin efficiently eradicates primitive leukemic cells in vitro suggesting FAK could be a useful therapeutic target for improved treatment of poor prognosis acute myeloid leukemia cases. [Stem Cells] Abstract Latent HIV-1 Infection Occurs in Multiple Subsets of Hematopoietic Progenitor Cells and Is Reversed by NF-κB Activation Investigators illuminated the mechanisms through which latent infection can be established in hematopoietic progenitor cells (HPCs) and suggested common pathways through which latent virus could be reactivated in both HPCs and resting memory T cells to eliminate latent reservoirs of HIV-1. [J Virol] Abstract Differential Control of Hypoxia-Inducible Factor 1 Activity during Pro-Inflammatory Reactions of Human Hematopoietic Cells of Myeloid Lineage Investigators report that mammalian target of rapamycin (mTOR) kinase is crucially involved in hypoxia-inducible factor 1α (HIF-1α) accumulation/HIF-1 activation in human THP-1 myeloid monocytes, LAD2 mast cells and primary basophils in a variety of different settings. [Int J Biochem Cell Biol] Abstract Acute Inducible Ablation of GRP78 Reveals Its Role in Hematopoietic Stem Cell Survival, Lymphogenesis and Regulation of Stress Signaling Researchers demonstrated that GRP78 plays a pleiotropic role in bone marrow cells and contributes to hematopoietic stem cell survival and the maintenance of the lymphoid lineage. [PLoS One] Full Article Distinctive Contact between CD34+ Hematopoietic Progenitors and CXCL12+ CD271+ Mesenchymal Stromal Cells in Benign and Myelodysplastic Bone Marrow Scientists analyzed putative mesenchymal stromal cell markers and their relationship to CD34+ hematopoietic stem/progenitor cells within intact human bone marrow in paraffin-embedded bone marrow core biopsies of benign, myelodysplastic syndrome and leukemic marrows using tissue microarrays to facilitate scanning, image analysis and quantitation. [Lab Invest] Abstract The Sorafenib Plus Nutlin-3 Combination Promotes Synergistic Cytotoxicity in Acute Myeloid Leukemic Cells Irrespectively of the FLT3 and p53 Status Researchers investigated the effect of Sorafenib plus Nutlin-3 combination in acute myeloid leukemia. [Haematologica] Abstract | Full Article CLINICAL RESEARCH T Cell Suicide Gene Therapy Prompts Thymic Renewal in Adults after Hematopoietic Stem Cell Transplantation In the TK007 clinical trial 22 adults with hematologic malignancies experienced a rapid and sustained immune recovery after T cell-depleted hematopoietic stem cell transplantation and serial infusions of purified donor T cells expressing the herpes simplex virus thymidine kinase suicide gene. [Blood] Abstract Thalidomide Plus Dexamethasone as a Maintenance Therapy after Autologous Hematopoietic Stem Cell Transplantation Improves Progression-Free Survival in Multiple Myeloma Researchers assessed the impact of thalidomide in maintenance after stem cell transplantation in untreated patients with multiple myeloma. [Am J Hematol] Abstract Prognostic Factors Affecting Outcome after Allogeneic Transplantation for Hematological Malignancies from Unrelated Donors: Results from a Randomized Trial This randomized, multi-center, open-label, phase III trial compared standard graft-versus-host-disease prophylaxis with and without pre-transplant ATG-Fresenius in 201 adult patients receiving myeloablative conditioning prior to hematopoietic stem-cell transplantation from HLA-A, -B antigen, -DRB1, -DQB1 allele matched unrelated donors. [Biol Blood Marrow Transplant] Abstract |
| SCIENCE NEWS | Pluristem Therapeutics’ Cell Therapy Broadens Addressable Markets – Demonstrates Systemic Effectiveness of Intramuscular Delivery The results of the study demonstrated a significant survival and recovery rate of bone marrow and peripheral blood counts in animals pre-irradiated by high lethal doses. These findings indicate that the intramuscular route of administration of placental expanded cells stimulate the hematopoietic stem cells of the bone marrow to produce red and white blood cells as well as platelets crucial for the treatment of hematological disorders. [Press release from Pluristem Therapeutics, Inc. discussing research presented at the 2012 Bio International Convention, Boston] Press Release |
| JOB OPPORTUNITIES | Research Associate – Chemistry (STEMCELL Technologies, Inc.) Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.) Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.) Research Technologist – Media Development (STEMCELL Technologies, Inc.) Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.) Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.) Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.) PhD Position – Construction of a Biomimetic, Hematopoietic Stem Cell Niche (Karlsruhe Institute of Technology – Helmholtz Association) Postdoctoral Position – Hematopoietic Stem Cell Biology and Immunology (University of California, San Francisco) Postdoctoral Position – Hematopoietic Lineage Commitment and Leukemia Development (University of Oxford – Weatherall Institute of Molecular Medicine) Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost. |
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