Hematopoiesis News Volume 4.45 | Nov 19 2013

A Network of Epigenetic Regulators Guides Developmental Hematopoiesis In Vivo
Investigators identified 15 factors that regulate development of primitive erythroid progenitors and 29 factors that regulate development of definitive hematopoietic stem and progenitor cells. [Nat Cell Biol] Abstract

Mortalin and DJ-1 Coordinately Regulate Hematopoietic Stem Cell Function Through the Control of Oxidative Stress
The inhibition of mortalin function caused abnormal reactive oxygen species elevation in hematopoietic stem cells (HSCs) and reduced HSC numbers. Knockdown of mortalin in hematopoietic stem and progenitor cells impaired their ability to repopulate and form colonies. [Blood] Abstract

Toward a Therapeutic Reduction of Imatinib Refractory Myeloproliferative Neoplasm-Initiating Cells
Although myeloproliferative neoplasms (MPNs) are sensitive to tyrosine kinase inhibitors such as imatinib, patients often relapse upon withdrawal of therapy. Scientists used a model of MPN, which is induced by co-expression of the oncoproteins HIP1/PDGFβR and AML1/ETO from their endogenous loci, to examine the mechanisms of disease development and recurrence following imatinib withdrawal. [Oncogene] Abstract

Proteome Changes Induced by c-myb Silencing in Human Chronic Myeloid Leukemia Cells Suggest Molecular Mechanisms and Putative Biomarkers of Hematopoietic Malignancies
To shed light on the molecular mechanisms associated with aberrant accumulation of c-Myb in chronic myeloid leukemia, comparative proteomic analysis was performed on c-myb RNAi-specifically silenced K562 cells, sampled on a time-course basis. [J Proteomics] Abstract

Differential Effects of Selective Inhibitors Targeting the PI3K/AKT/mTOR Pathway in Acute Lymphoblastic Leukemia
Dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors profoundly inhibited growth and survival of acute T-lymphoblastic leukemias cells irrespective of their genetic subtype and their responsiveness to ABL-tyrosine kinase inhibitors. [PLoS One] Full Article

Hsp90 Inhibitor BIIB021 Enhances Triptolide-Induced Apoptosis of Human T-Cell Acute Lymphoblastic Leukemia Cells In Vitro Mainly by Disrupting p53-MDM2 Balance
The authors investigated the effects of BIIB021, an inhibitor of heat shock protein 90 (Hsp90) alone or in combination with triptolide on T-cell acute lymphoblastic leukemia and the mechanisms of action. [Acta Pharmacol Sin] Abstract

CLINICAL RESEARCH

Pre-Transplant Prognostic Factors of Long-Term Survival After Allogeneic Peripheral Blood Stem Cell Transplantation with Matched Related/Unrelated Donors
In this retrospective single-center study of 442 patients with hematologic malignancies, scientists analyzed prognostic factors for long-term survival after peripheral blood stem cell transplantation from HLA-matched related or unrelated donors. [Haematologica] Abstract | Full Article

A Prospective Registration Study to Determine Feasibility of Hematopoietic SCT in Adults with Acute Leukemia: Planning, Expectations and Reality
The European Group for Blood and Marrow Transplantation Acute Leukemia Working Party prospectively followed 695 consecutive patients who were registered at the time of human leukocyte antigen typing. [Bone Marrow Transplant] Abstract

Neutropenia Associated with Anti-Human Neutrophil Antibodies Following Allogeneic Hematopoietic Stem Cell Transplantation
The authors present a case of anti-human neutrophil antigen (HNA) antibody-associated neutropenia following allogeneic hematopoietic stem cell transplantation. By monitoring representative anti-HNA antibodies, the patient showed a variety of anti-HNA antibodies; The authors speculated that the anti-HNA-2 antibody played a crucial role in the development of neutropenia. [Transpl Int] Abstract

A Prospective Multicenter Study of Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure
The EXPLORE study aimed to determine the prevalence of undiagnosed paroxysmal nocturnal hemoglobinuria (PNH) in patients with aplastic anemia, myelodysplastic syndrome, and/or other bone marrow failure syndromes and the effect of PNH clone size on hemolysis. [Cytometry B Clin Cytom] Abstract

Developmental Changes in Hematopoietic Stem Cell Properties
The authors summarize salient examples of differences in the properties of fetal and adult hematopoietic cells with a particular focus on those that affect or are initiated within the hematopoietic stem cell compartment. [Exp Mol Med] Full Article

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Gentium Receives EMA Orphan Drug Designation for Defibrotide for the Prevention of GvHD
Gentium S.p.A. announced that the European Commission (EC) has granted Orphan Drug Designation to defibrotide for the prevention of graft versus host disease (GvHD). [Gentium S.p.A.] Press Release

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NEW Postdoctoral Position – Hematopoietic Stem Cell Research (Lund Stem Cell Center)

PhD Position – Cancer Systems Biology/Leukemia Research (Universitätsklinikum Frankfurt a.M.)

Director of Sponsored Programs (Wake Forest Institute for Regenerative Medicine)

Adult Stem Cell Transplant Physician (John Theurer Cancer Center)

Postdoctoral Position – Transcriptional Regulation in Normal and Malignant Hematopoiesis (Karolinska Institute)

Postdoctoral Position – Hematopoietic Stem Cell Biology (St. Jude Children’s Research Hospital)

Postdoctoral Position – Human Pluripotent and Hematopoietic Stem Cell Bioinformatics (Albert Einstein College Medicine)

Translational Clinician-Scientist – Stem Cell Transplantation (Boston Children’s Hospital)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

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