LABORATORY RESEARCH Early Dynamic Fate Changes in Hemogenic Endothelium Characterized at the Single-Cell Level Scientists showed that initiation of the hematopoietic program occurs in cells still embedded in the endothelial layer, and is accompanied by a previously unrecognized early loss of endothelial potential before hematopoietic stem cells emerge. [Nat Commun] Abstract MOZ-Mediated Repression of p16INK4a Is Critical for the Self-Renewal of Neural and Hematopoietic Stem Cells Scientists showed that the histone acetyltransferase MOZ controls the proliferation of both hematopoietic and neural stem cells by modulating the transcriptional repression of p16INK4a. [Stem Cells] Abstract Low-Dose Triptolide in Combination with Idarubicin Induces Apoptosis in AML Leukemic Stem-Like KG1a Cell Line by Modulation of the Intrinsic and Extrinsic Factors The ability of triptolide to induce apoptosis in leukemic stem cell (LSC)-like cells derived from acute myeloid leukemia (AML) cell line KG1a was investigated. LSC-like cells sorted from KG1a were subjected to cell cycle analysis and different treatments, and then followed by in vitro methyl thiazole tetrazolium bromide cytotoxicity assay. [Cell Death Dis] Full Article The Aryl Hydrocarbon Receptor Antagonist StemRegenin 1 Promotes Human Plasmacytoid and Myeloid Dendritic Cell Development from CD34+ Hematopoietic Progenitor Cells Scientists showed that by inhibiting the aryl hydrocarbon receptor with its antagonist StemRegenin 1, clinical-scale numbers of functional BDCA2+BDCA4+ plasmacytoid blood dendritic cells (DCs), BDCA1+ myeloid blood DCs (mDCs) and BDCA3+DNGR1+ mDCs can be efficiently generated from human CD34+ hematopoietic progenitor cells. [Stem Cells Dev] Abstract An Unexpected Link between Notch Signaling and ROS in Restricting the Differentiation of Hematopoietic Progenitors in Drosophila The authors address the role of Notch signaling in lamellocyte differentiation in response to wasp infection. They showed that Notch activity is moderately high and ubiquitous in all cells of the lymph gland lobes, with crystal cells exhibiting the highest levels. [Genetics] Abstract Plerixafor Induces the Rapid and Transient Release of Stromal Cell-Derived Factor-1 Alpha from Human Mesenchymal Stromal Cells and Influences the Migration Behavior of Human Hematopoietic Progenitor Cells Investigators quantified the impact of plerixafor on the interaction between human bone marrow derived mesenchymal stromal cells and human CD34+ hematopoietic progenitor cells. [Cell Tissue Res] Abstract CLINICAL RESEARCH Cytokine and Chemokine Patterns Across One Hundred Days following Hematopoietic Stem Cell Transplantation in Children Researchers mapped the cytokine response to hematopoietic stem cell transplantation (HSCT) by assaying fifty-one cytokines and chemokines each week for one hundred days in fifty-one children receiving allogeneic or autologous HSCT. [Biol Blood Marrow Transplant] Abstract Antithymocyte Globulin in Reduced Intensity Conditioning Regimen Allows a High Disease-Free Survival Exempt of Long Term Chronic GVHD Researchers report a study conducted on 206 patients with a median age of 59 years, who received allogeneic hematopoietic stem cell transplantation prepared using fludarabine, 2 days of intravenous busulfan and 5 mg/kg of rabbit antithymocyte globulin, between 2005 and 2012. Grade III-IV acute and extensive chronic graft-versus-host diseases (GVHD) were 9% and 22%, respectively. [Biol Blood Marrow Transplant] Abstract |