LABORATORY RESEARCH Identification of Functional Cooperative Mutations of SETD2 in Human Acute Leukemia Researchers provided compelling evidence for SETD2 as a new tumor suppressor. Disruption of the SETD2-H3K36me3 pathway is a distinct epigenetic mechanism for leukemia development. [Nat Genet] Abstract | Press Release Epigenetic Regulation of GATA2 and Its Impact in Normal Karyotype Acute Myeloid Leukemia Using RNAseq researchers report that GATA2 is either mutated with functional consequence, or expressed at low levels in the majority of normal karyotype acute myeloid leukemia. [Leukemia] Abstract Chimeric Antigen Receptors against CD33/CD123 Antigens Efficiently Target Primary Acute Myeloid Leukemia Cells In Vivo Researchers describe the in vivo efficacy and safety of using cytokine-induced-killer cells genetically modified to express anti-CD33 or anti-CD123 chimeric antigen receptor to target acute myeloid leukemia. [Leukemia] Abstract A Non-Canonical Function of Telomerase RNA in the Regulation of Developmental Myelopoiesis in Zebrafish Investigators showed that genetic depletion of the telomerase RNA component in the zebrafish results in impaired myelopoiesis, despite normal development of hematopoietic stem cells. [Nat Commun] Abstract B-myb Is an Essential Regulator of Hematopoietic Stem Cell and Myeloid Progenitor Cell Development Researchers showed that conditional inactivation of B-myb in vivo results in depletion of the hematopoietic stem cell pool, leading to profound reductions in mature lymphoid, erythroid, and myeloid cells. [Proc Natl Acad Sci USA] Abstract | Full Article DNMT3A Arg882 Mutation Drives Chronic Myelomonocytic Leukemia through Disturbing Gene Expression/DNA Methylation in Hematopoietic Cells The authors addressed the transformation ability of the DNA methyltransferase 3A (DNMT3A)-Arg882His (R882H) mutant by using a retroviral transduction and bone marrow transplantation approach and found that the mutant gene can induce aberrant proliferation of hematopoietic stem/progenitor cells. [Proc Natl Acad Sci USA] Abstract Regulation of Trib2 by an E2F1-C/EBPalpha Feedback Loop in AML Cell Proliferation Researchers showed that E2F family members directly regulate Trib2 in leukemic cells and identify a feedback regulatory loop for E2F1, C/EBPalpha and Trib2 in acute myeloid leukemia (AML) cell proliferation and survival. [Blood] Abstract Stage-Specific Roles for Cxcr4 Signaling in Murine Hematopoietic Stem/Progenitor Cells in the Process of Bone Marrow Repopulation Investigators concluded that timely regulation of C-X-C chemokine receptor type 4 (Cxcr4)/CXCR4 signaling is key in providing donor hematopoietic stem/progenitor cells (HSPCs) with enhanced repopulation potential following transplantation, whilst preserving the ability to release HSPC progeny into peripheral blood for improved transplantation outcomes. [Stem Cells] Abstract CLINICAL RESEARCH The Addition of Sirolimus to Tacrolimus/Methotrexate GvHD Prophylaxis in Children with ALL: A Phase III COG/PBMTC Trial Researchers tested whether addition of sirolimus to GvHD prophylaxis of children undergoing transplantation for ALL would decrease acute GvHD and relapse, thus improving survival. [Blood] Abstract HLA-Haploidentical Hematopoietic SCT from Collateral Related Donors without In Vitro T-Cell Depletion for Hematological Malignancies The authors compared clinical outcomes of patients with hematological malignancies, who underwent haploidentical hematopoietic SCT from collateral related donors (n=30) and immediate related donors (n=120). [Bone Marrow Transplant] Abstract Win a $25 Amazon Gift Card! Connexon Creative is evaluating reader interest in a new social media platform. Fill out this quick survey for your chance to win 1 of 4 $25 gift cards! Take survey here |