Epigenetic Control of Dendritic Cell Development and Fate Determination of Common Myeloid Progenitor by Mysm1 Using a Mysm1 knockout (Mysm1-/-) mouse model, scientists identified the histone H2A deubiquitinase Mysm1 as a critical regulator in dendritic cell (DC) differentiation. Mysm1-/- mice showed a global reduction of DCs in lymphoid organs whereas development of granulocytes and macrophages were not severely affected. [Blood] Abstract CXCL12+ Stromal Cells as Bone Marrow Niche for CD34+ Hematopoietic Cells and Their Association with Disease Progression in Myelodysplastic Syndromes Using immunohistochemistry, scientists show that CXCL12+ cells were located in the cellular marrow or perivascular area, and were in contact with CD34+ hematopoietic cells in control and myelodysplastic syndromes/acute myelogenous leukemia with myelodysplasia-related changes bone marrow. [Lab Invest] Abstract Pre-Transplant Mobilization with Granulocyte Colony Stimulating Factor Improves B Cell Reconstitution by Lentiviral Vector Gene Therapy in SCID-X1 Mice Researchers hypothesized that mobilization of hematopoietic stem cell by granulocyte colony-stimulating factor should create temporary space in bone marrow niches to improve engraftment and thereby B cell reconstitution. [Hum Gene Ther] Abstract Characterization of Transcription Factor Networks Involved in Umbilical Cord Blood CD34+ Stem Cells-Derived Erythropoiesis Investigators utilized umbilical cord blood CD34+ stem cells induced to undergo erythroid differentiation to characterize the transcriptome and transcription factor networks associated with the γ/β-globin switch during fetal erythropoiesis. [PLoS One] Full Article Vasculogenic and Hematopoietic Cellular Progenitors Are Scattered within the Prenatal Mouse Heart Scientists characterized phenotypic profiles and location of putative vasculogenic and hematopoietic cellular progenitors in the embryonic mouse heart. [Histochem Cell Biol] Abstract | Full Article CLINICAL RESEARCH First-Line Treatment for Severe Aplastic Anemia in Children: Bone Marrow Transplantation from a Matched Family Donor vs. Immunosuppressive Therapy Researchers retrospectively compared the outcomes of children with acquired severe aplastic anemia who received immunosuppressive therapy within prospective trials conducted by the Japan Childhood Aplastic Anemia Study Group or who underwent bone marrow transplantation from an HLA-matched family donor registered in the Japan Society for Hematopoietic Cell Transplantation Registry. [Haematologica] Abstract | Full Article Hematological Recovery after Autologous Stem Cell Transplantation Is Associated with Favorable Outcome in Acute Myeloid Leukemia Investigators analyzed the prognostic significance of hematological recovery for neutrophils and platelets, stratifying at day 20 after autologous stem cell transplantation in 88 consecutive and homogeneously treated acute myeloid leukemia patients in first remission. [Br J Haematol] Abstract Comparative Analysis of Unrelated Cord Blood Transplantation and HLA-Matched Sibling Hematopoietic Stem Cell Transplantation in Children with High-Risk or Advanced Acute Leukemia Researchers present a clinical comparison of unrelated cord blood transplantation and human leukocyte antigen (HLA)-matched sibling allogeneic peripheral blood stem cell or bone marrow transplantation in children with high-risk or advanced acute leukemia. [Ann Hematol] Abstract |