Hematopoiesis News Volume 6.09 | Mar 10 2015

Runx1 Is Required for Hematopoietic Defects and Leukemogenesis in Cbfb-MYH11 Knockin Mice
The authors showed that a modified CBFβ-SMMHC with decreased RUNX1 binding activity accelerates leukemogenesis. These results raise questions about the importance of RUNX1 in leukemogenesis by CBFβ-SMMHC. [Leukemia] Abstract

Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Anti-Leukemic Effects
Researchers investigated expression and prognostic impact of Hedgehog pathway members in acute myeloid leukemia (AML). Pre-treatment samples from 104 newly diagnosed AML patients were analyzed by qPCR and expression of Hedgehog family members was correlated to clinical outcome. [Clin Cancer Res] Abstract

Conserved and Divergent Aspects of Human T Cell Development and Migration in Humanized Mice
Investigators found that both conventional T cell development and intra-thymic migration patterns in humanized mice closely resemble human thymopoiesis. [Immunol Cell Biol] Abstract | Full Article

Role of Transgene Regulation in Ex Vivo Lentiviral Correction of Artemis Deficiency
Researchers compared the human Artemis promoter to the moderate-strength human PGK promoter and the strong human EF1α promoter to regulate expression of Artemis after ex vivo lentiviral transduction of hematopoietic stem cells in a murine model of severe combined immunodeficiency. [Hum Gene Ther] Abstract

Enhanced Hematopoietic Stem Cell Function Mediates Immune Regeneration following Sex Steroid Blockade
Investigators showed that, mechanistically, sex steroid ablation induces hematopoietic and lymphoid recovery by functionally enhancing both hematopoietic stem cell self-renewal and propensity for lymphoid differentiation through intrinsic molecular changes. [Stem Cell Reports] Full Article | Graphical Abstract

CLINICAL RESEARCH

Haploidentical BMT and Post-Transplant Cy for Severe Aplastic Anemia: A Multicenter Retrospective Study
The use of post-transplant cyclophosphamide (Cy) has been shown to be an effective strategy to prevent GvHD in recipients of haploidentical hematopoietic SCT, but the majority of reports have focused on patients with hematology malignancies. Researchers describe the outcome of 16 patients who underwent haploidentical transplantation using a reduced-intensity conditioning regimen with post-transplant Cy. [Bone Marrow Transplant] Abstract

Co-Infusion of Mesenchymal Stromal Cells Has No Effect on Relapse and Infection in Leukemia Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplantation
Investigators observed the outcomes of mesenchymal stromal cells co-infusion during haploidentical hematopoietic stem cell transplantation (haplo-HSCT) and compared the relapse and infection rates with patients receiving traditional haplo-HSCT. [Leuk Lymphoma] Abstract

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AOP Orphan Pharmaceuticals Announces Progress of Pivotal Phase III Trial PROUD-PV Applying Ropeginterferon Alfa 2b, a Novel, Long-Acting, Mono-Pegylated Interferon for Treatment of Polycythemia Vera
AOP Orphan Pharmaceuticals AG reported the completion of recruitment for its Phase III trial PROUD-PV to support global licensure of ropeginterferon alfa 2b, a novel, long-acting, mono-pegylated Interferon for the treatment of Polycythemia Vera. [AOP Orphan Pharmaceuticals AG] Press Release

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Research Technologist – Hematopoietic Product Development (STEMCELL Technologies Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Stem Cell/Translational Medicine (Rutgers New Jersey Medical School)

Postdoctoral Position – Drug Development for Anemia (Lund University)

Postdoctoral Position – Pediatric Hematology and Oncology (University Medical Center of Freiburg)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Director – Vector Production (Sangamo BioSciences, Inc.)

Postdoctoral Position – Hematopoietic Stem Cell Physiology and Pathophysiology (Kumamoto University)

Postdoctoral Position – Genetic Engineering and Transplantation of Hematopoietic Stem Cells (University of California – San Francisco)

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