IP3 3-Kinase B Controls Hematopoietic Stem Cell Homeostasis and Prevents Lethal Hematopoietic Failure in Mice Investigators identified inositoltrisphosphate (IP3) 3-kinase B (Itpkb) as an essential regulator of hematopoietic stem cell (HSC) homeostasis. Young Itpkb-/- mice accumulated phenotypic HSC which were less quiescent and proliferated more than wildtype controls. [Blood] Abstract | Press Release Autophagy Is Required for Stem Cell Mobilization by G-CSF Scientists observed that granulocyte-colony stimulating factor (G-CSF) activates autophagy in neutrophils and hematopoietic stem cell from both mouse and human donors. [Blood] Abstract Microenvironmental Remodeling as a Parameter and Prognostic Factor of Heterogeneous Leukemogenesis in Acute Myeloid Leukemia Researchers assessed the bone marrow microenvironment of acute myeloid leukemia patients and demonstrated that the leukemia stem cells induce a change in the transcriptional programming of the normal mesenchymal stromal cells. [Cancer Res] Abstract IDH2 and NPM1 Mutations Cooperate to Activate Hoxa9/Meis1 and Hypoxia Pathways in Acute Myeloid Leukemia To determine whether mutant IDH enzymes are valid targets for cancer therapy, scientists created a mouse model of acute myeloid leukemia (AML) in which mice were transplanted with nucleophosmin1 (NPM1)+/- hematopoietic stem/progenitor cells co-transduced with four mutant genes which often occur simultaneously in human AML patients. [Cancer Res] Abstract Cyclin A1 Regulates the Interactions between Mouse Hematopoietic Stem and Progenitor Cells and Their Niches Investigators showed that the cell cycle regulator cyclin A1 in association with vascular endothelial growth factor receptor 1, is required for hematopoietic stem/progenitor cells and their niches to maintain their function and proper interaction. [Cell Cycle] Abstract Standard Sub-Thermoneutral Caging Temperature Influences Radiosensitivity of Hematopoietic Stem and Progenitor Cells Researchers report that the mild, but chronic cold-stress endured by mice housed under laboratory conditions exerts a protective effect on hematopoietic stem and progenitor cells after both non-lethal and lethal doses of total body irradiation. [PLoS One] Full Article MicroRNA-223 Regulates Granulopoiesis but Is Not Required for HSC Maintenance in Mice The authors characterized hematopoietic stem cell (HSC) function and myeloid differentiation in miR223 deficient mice. They showed that miR223 loss results in a modest expansion of myeloid progenitors, but is not sufficient to induce a myeloproliferative disorder. [PLoS One] Full Article CLINICAL RESEARCH Phase III Trial of Bortezomib, Cyclophosphamide, Dexamethasone (VCD) versus Bortezomib, Doxorubicin, Dexamethasone (PAd) in Newly-Diagnosed Myeloma Investigators aimed at demonstrating non-inferiority of VCD compared to PAd induction therapy with respect to very good partial response rates or better in 504 newly diagnosed, transplant-eligible multiple myeloma patients. [Leukemia] Abstract Allogeneic Transplantation with Myeloablative FluBu4 Conditioning Improves Survival Compared to Reduced Intensity FluBu2 Conditioning for Acute Myeloid Leukemia in Remission Because fludarabine with myeloablative doses of intravenous busulfan using pharmacokinetic monitoring has excellent tolerability, researchers reasoned that this regimen would limit relapse without substantially elevating toxicity when compared to reduced intensity conditioning. [Ann Hematol] Abstract Allogeneic Stem Cell Transplantation Using Lymphoablative Rather than Myeloablative Conditioning Regimen for Relapsed or Refractory Lymphomas Investigators treated 28 relapsed or refractory non-Hodgkin lymphomas with allogeneic hematopoietic stem cell transplantation. All were pre-conditioned with fludarabine and melphalan; 25 were additionally treated with total body irradiation. [Hematol Oncol] Abstract |