Hematopoiesis News Volume 6.15 | Apr 21 2015

Wip1 Deficiency Impairs Hematopoietic Stem Cell Function via p53 and mTORC1 Pathways
Researchers showed that wild-type p53-induced phosphatase 1 (Wip1) is highly expressed in hematopoietic stem cells (HSCs) but decreases with age. Wip1-deficient mice exhibited multifaceted HSC aging phenotypes, including the increased pool size and impaired repopulating activity. [Nat Commun] Abstract

Targeting of Folate Receptor-Beta on Acute Myeloid Leukemia Blasts with Chimeric Antigen Receptor Expressing T Cells
As many cell-surface markers are shared between acute myeloid leukemia blasts and healthy hematopoietic stem and progenitor cells (HSCs), investigators evaluated folate receptor β expression and recognition of HSCs by chimeric antigen receptor T cells. [Blood] Abstract

Macrophage-Lineage Cells Negatively Regulate the Hematopoietic Stem Cell Pool in Response to IFNγ at Steady State and during Infection
Scientists demonstrated that depletion of bone marrow resident macrophages increases hematopoietic stem cell (HSC) proliferation as well as the pool of quiescent HSCs. [Stem Cells] Abstract

hCD2-iCre and Vav-iCre Mediated Gene Recombination Patterns in Murine Hematopoietic Cells
To better characterize which hematopoietic cells contain hCD2-iCre activity, investigators compared EYFP fluorescence in hCD2-iCre^+/- R26-stop-EYFP^+/- and Vav-iCre^+/- R26-stop-EYFP^+/- mice. [PLoS One] Full Article

CLINICAL RESEARCH

Randomized Study of Reduced-Intensity Chemotherapy Combined with Imatinib in Adults with Ph-Positive Acute Lymphoblastic Leukemia
Scientists randomly compared high doses of the tyrosine kinase inhibitor imatinib combined with reduced-intensity chemotherapy to standard imatinib/HyperCVAD treatment in 268 adults with Ph-positive acute lymphoblastic leukemia. [Blood] Abstract

Comparison of Outcomes after Unrelated Cord Blood and Unmanipulated Haploidentical Stem Cell Transplantation in Adults with Acute Leukemia
Investigators compared outcomes after unrelated cord blood transplantation and haploidentical stem cell transplantation in adults with de novo acute myeloid leukemia and acute lymphoblastic leukemia. [Leukemia] Abstract

Does Defibrotide Induce a Delay to Polymorphonuclear Neutrophil Engraftment after Hematopoietic Stem Cell Transplantation? Observation in a Pediatric Population
Researchers investigated whether defibrotide (DFT) prophylaxis affects neutrophil engraftment in patients undergoing hematopoietic stem cell transplantation (HSCT). A cohort of 44 consecutive pediatric patients who underwent HSCT was retrospectively analyzed to see the role of DFT on engraftment. [Adv Ther] Abstract

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Panther Biotechnology Announces New Drug Candidate to Selectively Kill Leukemia Stem Cells
Panther Biotechnology, Inc. announced that it has entered into an exclusive global license agreement with the University of Rochester. Under the terms of the agreement, Panther has licensed from the University of Rochester, the rights to develop and commercialize a first in class new chemical entity with demonstrated powerful anti-leukemia activity. [Panther Biotechnology, Inc. (Marketwired L.P.)] Press Release

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Food and Drug Administration (United States)

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Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Hematopoietic Stem Cell Biology (University of Leuven)

Postdoctoral Fellow – Stem Cell Trans Regulation (BloodCenter of Wisconsin)

Postdoctoral Fellow – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Fellow – Hematopoietic Stem Cell Research (Lund University)

Postdoctoral Research Fellow – Stem Cell/Hematopoiesis Research (BloodCenter of Wisconsin)

Postdoctoral Fellow – Bioinformatics and Stem Cell Biology (The University of Texas Medical School at Houston)

Research Associate – Hematopoietic and Leukemic Stem Cells (Shanghai Jiao Tong University)

Postdoctoral Position – Drug Development for Anemia (Lund University)

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