Hematopoiesis News Volume 6.17 | May 5 2015

Hypoxia Inducible Factor (HIF)-2α Accelerates Disease Progression in Mouse Models of Leukemia and Lymphoma but Is Not a Poor Prognosis Factor in Human AML
HIF-1α accumulation promotes hematopoietic stem cells quiescence and is necessary to maintain their self-renewal. Researchers investigated the role of HIF-2α in leukemia and lymphoma cells. HIF-2α expression was high in subsets of human and mouse leukemia and lymphoma cells whereas it was low in normal bone marrow leukocytes. [Leukemia] Abstract

The BMI1 Polycomb Protein Represses CyclinG2-Induced Autophagy to Support Proliferation in Chronic Myeloid Leukemia Cells
The BMI1 polycomb protein regulates self-renewal, proliferation and survival of cancer-initiating cells essentially through epigenetic repression of the CDKN2A tumor suppressor locus. Scientists demonstrated for the first time that BMI1 also prevents autophagy in chronic myeloid leukemia cell lines, to support their proliferation and clonogenic activity. [Leukemia] Abstract

Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-Selectin Activity
Using chemical and genetic approaches targeting cannabinoids (CB)-signaling in zebrafish, scientists showed that CB receptor (CNR)2, but not CNR1, regulates embryonic hematopoietic stem cell development. [Stem Cells] Abstract

Pbx3 and Meis1 Cooperate through Multiple Mechanisms to Support Hox-Induced Murine Leukemia
Hox homeobox transcription factors drive leukemogenesis efficiently only in the presence of Meis or Pbx proteins. The authors showed that Pbx3 and Meis1 need to dimerize to support Hox-induced leukemia and they analyzed the molecular details of this cooperation. [Haematologica] Abstract | Full Article

MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis
The authors identified a conserved microRNA-124 (miR-124) binding site on the Tip110 3′ untranslated region (3’UTR) and showed that Tip110 was down-regulated by miR-124 through its 3’UTR. They then examined the relationship among miR-124 and Tip110 expression and differentiation of human cord blood CD34⁺ cells. [Stem Cells Dev] Abstract

CLINICAL RESEARCH

Bendamustine, Bortezomib and Prednisone for the Treatment of Newly Diagnosed Multiple Myeloma Patients: Results of a Prospective Phase II Spanish/Pethema Trial
Sixty newly diagnosed myeloma patients received bendamustine plus bortezomib and prednisone consisting of one cycle of bortezomib twice per week for six weeks, plus bendamustine and prednisone. [Haematologica] Abstract | Full Article

Second Allogeneic Transplantation Using Unrelated Cord Blood for Relapsed Hematological Malignancies after Allogeneic Transplantation
Investigators analyzed the results of second allogeneic stem cell transplantation using single-unit unrelated cord blood in 34 adult patients with relapsed hematological malignancies after initial allogeneic stem cell transplantation in their institution. [Leuk Lymphoma] Abstract

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Generon Received US FDA Clearance to Initiate Phase IIa Study with F-652, a First-in-Class Biologic, to Treat Patients with Acute GvHD
Generon Corporation announced that it received US FDA clearance of the IND for a Phase IIa study, entitled “Recombinant Human Interleukin-22-IgG2-Fc (F-652) in Combination with Systemic Corticosteroids for the Treatment of Newly Diagnosed Grade II-IV Lower Gastrointestinal Acute Graft-versus-Host Disease in Hematopoietic Stem Cell Transplantation Recipients.” [Generon (Shanghai) Corporation Ltd.] Press Release

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Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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NEW Postdoctoral Positions – Regulation of Normal and Malignant Hematopoiesis (Karolinska Institute)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Hematopoietic Stem Cell Physiology and Pathophysiology (International Research Center for Medical Sciences)

Postdoctoral Associate – Epigenetic Regulation of Normal and Leukemic Stem Cells (Sanford-Burnham Medical Research Institute)

Postdoctoral Fellow – Hematopoietic Stem Cell Biology (University of Leuven)

Postdoctoral Fellow – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Fellow – Hematopoietic Stem Cell Research (Lund University)

Postdoctoral Research Fellow – Stem Cell/Hematopoiesis Research (BloodCenter of Wisconsin)

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