Hematopoiesis News Volume 6.42 | Oct 27 2015

JMJD1C Is Required for the Survival of Acute Myeloid Leukemia by Functioning as a Coactivator for Key Transcription Factors
Scientists demonstrated that the histone demethylase JMJD1C functions as a coactivator for RUNX1–RUNX1T1 and is required for its transcriptional program. [Genes Dev] Abstract | Press Release

Agonist Antibody That Induces Human Malignant Cells to Kill One Another
Recently, investigators discovered a phenomenon that they call “receptor pleiotropism” in which agonist antibodies against known receptors induce cell fates that are very different from those induced by the natural agonist to the same receptor. Here, they showed that one can take advantage of this phenomenon to convert acute myeloblastic leukemic cells into natural killer cells. [Proc Natl Acad Sci USA] Abstract | Press Release

Phenotypic, Morphological and Adhesive Differences of Human Hematopoietic Progenitor Cells Cultured on Murine versus Human Mesenchymal Stromal Cells
Researchers evaluated the proliferative capacity, morphological and physical characteristics of human CD34⁺ hematopoietic stem and progenitor cells after co-culture on murine or human bone marrow-derived mesenchymal stromal cells. [Sci Rep] Full Article

SKLB-677, an FLT3 and Wnt/β-Catenin Signaling Inhibitor, Displays Potent Activity in Models of FLT3-Driven AML
Scientists report the characterization of SKLB-677, a new FLT3 inhibitor developed recently. This compound showed considerable suppression effects on leukemia stem-like cells in in vitro functional assays, but had no influence on normal hematopoietic stem cells. [Sci Rep] Full Article

Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells
Scientists showed that a simple block of cell differentiation is sufficient to induce and maintain stem cells. By overexpression of the transcriptional inhibitor ID3 in murine hematopoietic progenitor cells and cultivation under B cell induction conditions, the cells underwent developmental arrest and enter a self-renewal cycle. [Stem Cell Reports] Full Article | Graphical Abstract | Press Release

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia
To study acute lymphoblastic leukemia in a model of in vivo relevance, the authors engineered a 3-D microfluidic cell culture platform. They showed decreased chemotherapeutic drug sensitivity of leukemic cells in 3-D tri-culture models from the 2-D models. [PLoS One] Full Article

CLINICAL RESEARCH

Sirolimus Is Effective in Relapsed/Refractory Autoimmune Cytopenias: Results of a Prospective Multi-Institutional Trial
Scientists present data on 30 patients treated on a multicenter prospective clinical trial using sirolimus as monotherapy. [Blood] Abstract | Press Release

Outcomes of Allogeneic Hematopoietic Cell Transplantation in Patients with Biphenotypic Acute Leukemia
The authors retrospectively analyzed the outcomes of hematopoietic cell transplantation in biphenotypic acute leukemia patients in Japan in comparison to acute myeloid leukemia and acute lymphoblastic leukemia using the registration data from a nationwide database. [Ann Hematol] Abstract

Improved Outcomes of Hematopoietic Stem Cell Transplantation in Patients with Infantile Malignant Osteopetrosis Using Fludarabine-Based Conditioning
Investigators present their experience with hematopoietic stem cell transplantation for infantile malignant osteopetrosis patients comparing different types of conditioning regimens. [Pediatr Blood Cancer] Abstract

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New Anticancer Drug Discovery Company
A new company, Femtogenix Ltd, has been formed by King’s College London and Research Corporation Technologies. The main aim of Femtogenix is to develop a new generation of very potent molecules—known as ‘payloads’—that can be attached to targeting systems and then used as a form of highly specific chemotherapy to kill cancer cells with greatly reduced side effects. [King’s College London] Press Release

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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NEW PhD Studentships – Cancer Research (Cancer Research UK Manchester Institute)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Assistant or Associate Professor – Cell and Regenerative Biology (University of Wisconsin, Madison)

Postdoctoral Research Fellow – Medicinal Chemistry for Cancer Drug Discovery (University of Michigan)

Research Technician – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – iPSC Models of Hematologic Disorders (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Leukemia Stem Cell Biology (Lund University)

Postdoctoral Fellow – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Positions – Cancer and Developmental Biology (North Carolina Central University)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Postdoctoral Position – Hematology and Immunology (University of Liege)

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