Hematopoiesis News Volume 6.44 | Nov 10 2015

Low-Cell-Number Epigenome Profiling Aids the Study of Lens Aging and Hematopoiesis
Recovery via protection-chromatin-immunoprecipitation-based deep sequencing (RP-ChIP-seq) allowed detection of age-associated epigenetic changes in a single mouse lens, whereas favored amplification RP-ChIP-seq accurately mapped histone H3 lysine 4 trimethylation (H3K4me3) and H3K27me3 in long-term hematopoietic stem cells (HSCs), short-term HSCs, and multi-potent progenitors from one mouse. [Cell Rep] Full Article | Graphical Abstract

UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development
Researchers report that UFBP1 (Ufm1 binding protein 1) is indispensable for embryonic development and hematopoiesis. [PLoS Genet] Full Article

The Role of CD44 in Fetal and Adult Hematopoietic Stem Cell Regulation
CD44 expression and function were assessed and characterized on both fetal and adult hematopoietic stem cells. [Haematologica] Abstract | Full Article

ZFP36L1 Promotes Monocyte/Macrophage Differentiation by Repressing CDK6
Investigators identified that ZFP36L1 exhibits significant decrease in acute myeloid leukemia patients compared with normal controls and remarkable time-course increase during monocyte/macrophage differentiation of PMA-induced THP-1 and HL-60 cells as well as induction culture of CD34⁺ hematopoietic stem/progenitor cells. [Sci Rep] Full Article

DNA-Methylation in C1R Is a Prognostic Biomarker for Acute Myeloid Leukemia
Analysis of DNA-methylation at complement component 1 subcomponent R (C1R) provided a simple, robust, and cost-effective biomarker to further complement risk assessment in acute myeloid leukemia. [Clin Epigenetics] Full Article

Identification of a Hematopoietic Cell Dedifferentiation-Inducing Factor
Researchers found that using a conditioned medium from proliferating fibroblasts can induce a subset of hematopoietic cells to become adherent fibroblast-like cells. [J Cell Physiol] Abstract

CLINICAL RESEARCH

Phase II Study of Allogeneic Transplantation for Older Patients with Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results from Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502
The authors prospectively determined the value of hematopoietic stem-cell transplantation for older patients with acute myeloid leukemia in first complete remission. [J Clin Oncol] Full Article | Press Release

T-Replete Haploidentical Allogeneic Transplantation Using Post-Transplantation Cyclophosphamide in Advanced AML and Myelodysplastic Syndromes
Scientists analyzed 60 consecutive patients with refractory or high-risk CR AML or myelodysplastic syndromes who underwent post-transplantation cyclophosphamide haplo-transplantation. [Bone Marrow Transplant] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

NIH Awards City of Hope $2.2 Million Grant for Study of Chronic Graft-versus-Host Disease
The National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) has awarded a $2.2 million grant to help City of Hope researchers explore the underlying mechanisms of graft-versus-host disease, the leading cause of long-term sickness and death following transplantation of bone marrow cells from a donor. [City of Hope (Business Wire)] Press Release

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Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Leukemia Research (City of Hope)

Postdoctoral Position – Stem Cells and Leukemia (Florida State University)

PhD Studentships – Cancer Research (Cancer Research UK Manchester Institute)

Assistant or Associate Professor – Cell and Regenerative Biology (University of Wisconsin, Madison)

Postdoctoral Research Fellow – Medicinal Chemistry for Cancer Drug Discovery (University of Michigan)

Research Technician – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – iPSC Models of Hematologic Disorders (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Positions – Cancer and Developmental Biology (North Carolina Central University)

Assistant Professor – Stem Cell Biology (University of South Carolina)

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