Hematopoiesis News Volume 7.04 | Feb 2 2016

Tetraspanin CD37 Protects against the Development of B Cell Lymphoma
Scientists provided evidence that deficiency of tetraspanin superfamily member CD37, which is important for B cell function, induces the development of B cell lymphoma. [J Clin Invest] Full Article

HIF-1α Regulates the Interaction of Chronic Lymphocytic Leukemia Cells with the Tumor Microenvironment
The authors found that in chronic lymphocytic leukemia (CLL) hypoxia-inducible transcription factors (HIF)-1α is a novel regulator of the interaction of CLL cells with protective leukemia microenvironments, and is in turn regulated by this interaction in a positive feedback loop that promotes leukemia survival and propagation. [Blood] Abstract

The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations
The authors investigated the anti-leukemia activity of a MEK1 and FLT3 dual inhibitor, E6201, in acute myeloid leukemia (AML) cells resistant to FLT3 inhibition. They found that E6201 exerted profound apoptogenic effects on AML cells harboring resistance-conferring FLT3 mutations. [Cancer Res] Abstract

Epigenetic Regulation of Hematopoiesis by DNA Methylation
Investigators showed that DNA methyltransferase 3bb.1 is essential for maintenance of hematopoietic stem and progenitor cell (HSPC) fate as part of an early Notch-runx1-cmyb HSPC specification pathway in the zebrafish. [eLife] Full Article

Diet-Induced Obesity in Mice Diminishes Hematopoietic Stem and Progenitor Cells in the Bone Marrow
Researchers studied how diet-induced obesity affects hematopoietic stem and progenitor cell population dynamics in the bone marrow. [FASEB J] Abstract | Full Article

CD45RA, a Specific Marker for Leukemia Stem Cell Sub-Populations in Acute Myeloid Leukemia
Scientists investigated the potency of CD45RA to specifically identify leukemic stem cells (LSCs) and hematopoietic stem cells and improve LSC quantification. [Br J Haematol] Abstract

MPT0B169, a New Antitubulin Agent, Inhibits Bcr-Abl Expression and Induces Mitochondrion-Mediated Apoptosis in Nonresistant and Imatinib-Resistant Chronic Myeloid Leukemia Cells
Researchers investigated the antitumor effect and mechanism of MPT0B169, a new antitubulin agent, in K562 chronic myeloid leukemia cells and their derived imatinib-resistant cells, IMR2 and IMR3. IMR2 and IMR3 cells showed complete resistance to imatinib-induced growth inhibition and apoptosis. [PLoS One] Full Article

CLINICAL RESEARCH

Allogeneic T Cells that Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies that Progress after Allogeneic Hematopoietic Stem-Cell Transplantation without Causing Graft-versus-Host Disease
Researchers conducted a clinical trial of allogeneic T cells genetically engineered to express a chimeric antigen receptor (CAR) targeting the B-cell antigen CD19. Patients with B-cell malignancies that had progressed after allogeneic hematopoietic stem-cell transplantation received a single infusion of CAR T cells. [J Clin Oncol] Abstract | Press Release

Association of Acute Myeloid Leukemia’s Most Immature Phenotype with Risk Groups And Outcomes
The authors analyzed the clinical utility of a novel assay for putative leukemia stem cells in a large prospective cohort. The leukemic clone’s most primitive hematopoietic cellular phenotype was prospectively identified in 109 newly-diagnosed acute myeloid leukemia patients, and correlated with clinical risk groups and outcomes. [Haematologica] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

NUI Galway Launch €6 Million Robotic Stem Cell Production Project
NUI Galway’s Regenerative Medicine Institute has launched a new €6 million research project AUTOSTEM to develop pioneering manufacturing systems for stem cell therapy. Funded by the EU Horizon 2020 program, AUTOSTEM will go a long way towards meeting the demand for these new treatments, by transforming the way stem cells are manufactured. [National University of Ireland, Galway] Press Release

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Postdoctoral Researcher – Pre-Leukemic Stem Cells in the Thymus (Ghent University)

Research Fellow/Research Officer – Zeb2 Transcription Factor in Hematopoietic Stem Cell Differentiation (Monash University)

Laboratory Technician – Molecular Biology (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Stem Cell Biology (Krembil Research Institute)

Postdoctoral Scholarship – Cancer Biology (Lund University)

Science Content Writer (Howard Hughes Medical Institute)

Postdoctoral Fellowship – Tumor Immunology and Cancer Metabolism (Yale University)

Research Specialist – Stem Cells from the Hematopoietic System (Howard Hughes Medical Institute)

Postdoctoral Fellow – Leukemia Biology (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Epigenetics and RNA Splicing (National Cancer Institute)

Postdoctoral position – Regenerative Medicine (University of Copenhagen)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

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