Hematopoiesis News 7.30 August 2, 2016 | |
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TOP STORYThe authors report changes in lineage markers including myeloid conversion in patients following CD19 chimeric antigen receptor (CAR) therapy. Using murine acute lymphoblastic leukemia models they studied the long-term effects of CD19 CAR-T cells and demonstrate partial or complete lineage switch as a consistent mechanism of CAR resistance depending on the underlying genetic oncogenic driver. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators report that angiopoietin-like protein 4 (ANGPTL4) is the most highly upregulated gene in foamy macrophages and its absence in hematopoietic cells results in larger atherosclerotic plaques, characterized by bigger necrotic core areas and increased macrophage apoptosis. [Nat Commun] Full Article EKLF/KLF1-Regulated Cell Cycle Exit Is Essential for Erythroblast Enucleation Scientists used imaging flow cytometry to investigate the role of Erythroid Krüppel Like Factor (EKLF) in vivo, and remove performed functional studies using an ex vivo culture system that enriches for terminally differentiating cells. [Blood] Abstract Despite the fact that complement cascade cleavage fragments alone do not chemoattract normal hematopoietic stem/progenitor cells, researchers found that leukemia cell lines as well as clonogenic blasts from CML and AML patients respond robustly to C3 and C5 cleavage fragments by chemotaxis and increased adhesion. [Leukemia] Abstract | Full Article Scientists report here that Slug, a zinc-finger transcription repressor, functions as a direct transcriptional repressor of c-Kit in hematopoietic stem cells. [Leukemia] Abstract Investigators analyzed the morphology, immunophenotype, differentiation potential (adipogenic, osteogenic and chondrogenic), hematopoietic support and immunosuppressive capacity of bone marrow mesenchymal stromal cells from short scale cultures and clinical scale cultures in a comparative manner. [Stem Cells Dev] Abstract Scientists examined the role of the Hedgehog signaling pathway in acute myeloid leukemia cells, and evaluated the in vitro and in vivo effects of the Smoothened inhibitor PF-913. [Cancer Sci] Abstract Bone Marrow-Derived Progenitor Cells Are Functionally Impaired in Ischemic Heart Disease To determine whether the presence of ischemic heart disease per se, or rather the co-presence of heart failure (HF), is the primum movens for less effective stem cell products in autologous stem cell therapy, researchers assessed numbers and function of bone marrow-derived progenitor cells in patients with coronary artery disease, HF due to ischemic cardiomyopathy, non-ischemic HF, and control subjects. [J Cardiovasc Transl Res] Abstract CLINICAL RESEARCHInvestigators conducted an analysis of ECOG 2993/UKALLXII trial to study delays in post-remission chemotherapy in adults with newly-diagnosed acute lymphoblastic leukemia. [Am J Hematol] Abstract To determine the association of somatic mutations in acute myeloid leukemia (AML) with risk of relapse after allogeneic hematopoietic stem cell transplantation (alloHSCT), researchers retrospectively studied pre-transplant genetic profiles obtained from next generation sequencing of 26 genes in 112 adult AML patients who underwent alloHSCT. [Biol Blood Marrow Transplant] Abstract | |
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REVIEWSDrosophila Hematopoiesis under Normal Conditions and in Response to Immune Stress The authors provide an overview of Drosophila hematopoiesis during development and summarizes the current knowledge on the molecular processes controlling larval hematopoiesis, both under normal conditions and in response to an immune challenge, such as wasp parasitism. [FEBS Lett] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSMEI Pharma, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation for the investigational drug Pracinostat in combination with azacitidine for the treatment of patients with newly diagnosed acute myeloid leukemia who are ≥75 years of age or unfit for intensive chemotherapy. [MEI Pharma, Inc.] Press Release With Rise of Leukemia in Children, $6 Million Grant Funds Search for Causes A Berkeley-led research team will search for causes of leukemia with a new, four-year, $6 million grant from the Environmental Protection Agency and the National Institute of Environmental Health Sciences. [University of California, Berkeley] Press Release | Grant | |
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POLICY NEWSScientists Seek Influence on ‘Brexit Ministry’ Worried at the prospect of losing access to EU funding and collaborations, scientific societies have fired off numerous letters asking the government to keep their country in the EU’s research system, and warning of damage already caused by Brexit. [Nature News] Editorial Brain Implants and Gene-Editing Enhancements Worry US Public Most people in the United States are more worried than enthusiastic about the prospect of scientific advances such as gene editing and brain-chip implants, a survey of thousands suggests. [Nature News] Editorial | Poll Major Review Calls Time on ‘Gaming’ in UK Research Assessment The United Kingdom’s mammoth periodic audit of its research is set for a shake-up that could change the way universities hire academics – and might also encourage scientists to spend more time on public engagement. [Nature News] Editorial Antibiotics Funding Splurge Gets Mixed Reception Antibiotics researchers are set to receive hundreds of millions of dollars from a new funding stream — but not everyone thinks the cash is being directed to the right place. [Nature News] Editorial Young Blood Antiaging Trial Raises Questions A startup company has launched the first clinical trial in the United States to test the antiaging benefits of young blood in relatively healthy people. But there’s a big caveat: It’s a pay-to-participate trial, a type that has raised ethical concerns before, most recently in the stem cell field. [ScienceInsider] Editorial Dispute over President’s Age Tears Pasteur Institute Apart Is 65 too old to stay at the helm of a major research center? That question is sowing division at the Pasteur Institute in Paris, Science has learned, and has plunged the 128-year-old institute, home to 1200 scientists and the place where HIV was first isolated, into a leadership crisis. [ScienceInsider] Editorial U.S. Mental Health Institute Puts Champion of Basic Science at the Helm Up to now, Joshua Gordon has split his career between working with patients with mental illness and mice designed to mimic that illness. But this fall, the neuroscientist and psychiatrist will take control of the $1.5 billion U.S. National Institute of Mental Health in Bethesda, Maryland. [ScienceInsider] Editorial | Press Release Pan-European Pension Fund for Scientists Leaves the Station A pan-European pension fund for researchers, called RESAVER, was set up by a consortium of employers to stimulate researcher mobility. [ScienceInsider] Editorial
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EVENTSNEW T-ALL Workshop Visit our events page to see a complete list of events in the hematopoiesis community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Tumor Immunology (Roswell Park Cancer Institute) Technical Sales Representative (STEMCELL Technologies Inc.) Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania) Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center) Postdoctoral Fellow – Tumor Microenvironment and Cancer Stem Cells (Duke University) Cytogenetics Laboratory Supervisor (Fred Hutchinson Cancer Research Center) Postdoctoral Fellow – Hematopoietic Stem Cell Biology (Novartis) Research Technician – Hematopoietic Stem Cell Biology (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Hematopoiesis News Volume 7.30 | Aug 2 2016