Hematopoiesis News 8.45 November 14, 2017 | |
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TOP STORYHuman NOTCH4 Is a Key Target of RUNX1 in Megakaryocytic Differentiation Using integrative genomic analysis of hematopoietic progenitor cells generated from familial platelet disorder induced pluripotent stem cells (iPSCs), and mutation-corrected isogenic controls, scientists identified two gene sets whose transcription is either up- or downregulated by RUNX1 in mutation-corrected iPSCs. [Blood] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Neuropeptide Y Regulates a Vascular Gateway for Hematopoietic Stem and Progenitor Cells Investigators showed that enzymatically altered neuropeptide Y signaling in endothelial cells (ECs) caused reduced VE-cadherin and CD31 expression along EC junctions, resulting in increased vascular permeability and hematopoietic stem and progenitor cell egress. [J Clin Invest] Full Article The authors report the first global RNA-binding protein transcriptomic analysis of myeloid differentiation by combining RNA-seq analysis with myeloid induction in CD34+ hematopoietic progenitor cells. [Nat Commun] Full Article A Molecular Roadmap of the AGM Region Reveals BMPER as a Novel Regulator of HSC Maturation To identify novel secreted regulators of HSC maturation, researchers performed RNA sequencing over spatiotemporal transitions in the aorta-gonad-mesonephros (AGM) region and supportive OP9 cell line. [J Exp Med] Full Article PKC Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia The authors showed that RNA interference-mediated inhibition of the serine/threonine kinase PKC-epsilon reduces cell survival in a diverse panel of patient-derived acute myeloid leukemia (AML) samples and significantly delays disease onset in a genetically engineered mouse model of AML driven by MLL-AF9. [Clin Cancer Res] Abstract Pooled CD34+ cells and colony forming units from sickle bone marrow were treated with nuclease only or including a donor template, and then analyzed for the potential gene rearrangements. [Mol Ther] Abstract Caffeic Acid Phenethyl Ester Promotes Hematopoietic Stem/Progenitor Cell Homing and Engraftment Scientists determined whether caffeic acid phenethyl ester has a novel function in improving the homing and engraftment of hematopoietic stem/progenitor cells by regulating hypoxia inducible factor-1α gene expression in the bone marrow niche. [Stem Cell Res Ther] Full Article Investigation of FoxO3 Dynamics during Erythroblast Development in β-Thalassemia Major Using primary CD34+ hematopoietic progenitor cells from patients with β-thalassemia major, investigators successfully developed an in vitro model of ineffective erythropoiesis. [PLoS One] Full Article CLINICAL RESEARCHTransplant Results in Adults with Fanconi Anemia Researchers retrospectively analyzed 199 adult patients with Fanconi anemia (FA) transplanted between 1991 and 2014. Patients were a median of 16 years of age when diagnosed with FA, and underwent transplantation at a median age of 23 years. [Br J Haematol] Abstract Scientists analyzed patients affected by metastatic renal cell carcinoma who received an allogeneic hematopoietic stem cell transplantation between 1998 and 2006 in Milano, Marseille, Clermont-Ferrand and Stockholm. The 14 bp polymorphism was analyzed in correlation with overall survival, PFS, acute and chronic GvHD. [Bone Marrow Transplant] Abstract The authors report the use of automated red cell exchange in preparation for filgrastim mobilization in a patient with homozygous sickle cell anemia. Red cell exchange was repeated just prior to high-dose chemotherapy to mitigate the need for red cell transfusion during bone marrow reconstitution. [J Clin Apher] Abstract | |
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REVIEWSThe authors describe the method and the rationale of autologous hematopoietic stem cell transplantation, the more recently published studies that demonstrate its efficacy in selected multiple sclerosis cases, the problems related to safety and the transplant-related mortality risk of the procedure. [Mult Scler] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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SCIENCE NEWSProlong Pharmaceuticals announced that researchers will present interim results from a Phase II trial of SANGUINATE®, an investigational treatment under evaluation for VOC in patients with sickle cell disease. [Press release from Prolong Pharmaceuticals, LLC (PR Newswire Association, LLC.) discussing research to be presented at the 59th Annual Meeting and Exposition of the American Society of Hematology (ASH), Atlanta] Press Release | |
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INDUSTRY NEWSCerus Corporation Receives IDE Approval to Initiate Phase III ReCePI Study Cerus Corporation announced it has received an investigational device exemption (IDE) approval from the FDA to initiate ReCePI (A Randomized, Double-Blinded, Controlled, Parallel Group, Non-inferiority, Phase III Study to Evaluate the Efficacy and Safety of the INTERCEPT Blood System for Red Blood Cells in Patients undergoing Complex Cardiac Surgery Procedures). [Cerus Corporation] Press Release FDA Approves First Treatment for Certain Patients with Erdheim-Chester Disease, a Rare Blood Cancer The FDA expanded the approval of Zelboraf to include the treatment of certain adult patients with Erdheim-Chester Disease, a rare cancer of the blood. [The U.S. Food and Drug Administration] Press Release | |
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POLICY NEWSGraduate Students Face Alarming Tax Hike The last thing that graduate students need is a tax hike. But that is what many would face under a clause in the federal-tax-reform bill passed by the US House of Representatives. It will need to be reconciled with the Senate’s tax-reform bill (which retains many existing student tax benefits), and signed by the president. [Nature News] Editorial WHO Calls for Restrictions on Use of Antibiotics in Food Animal Production The World Health Organization is urging countries to restrict the amount of antibiotics given in food animal production by prohibiting their routine use in growth promotion and disease prevention. The recommendation is one of a number the WHO issued aimed at preserving the effectiveness of antibiotics. [STAT News] Editorial UK Government Appoints Next Chief Scientific Adviser Patrick Vallance, president of research and development at the pharmaceutical giant GlaxoSmithKline, has been appointed as chief scientific adviser, the UK government announced. [Nature News] Editorial
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EVENTSNEW 14th Annual Stem Cell Symposium: Technology Innovation for Stem Cell Research and Therapy Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scientist – Molecular Genetics of Human T Cell Development (Ghent University) NEW PhD Position – 3D Models of the Stem Cell Niche (Karlsruhe Institute of Technology) PhD Studentships – Cancer Research (University of Cambridge) Staff Scientist – Normal and Malignant Hematopoiesis (University of Copenhagen) Faculty Positions – Hematological Malignancies (University of Alabama at Birmingham) Postdoctoral Fellow – Hematology (University of Tennessee Health Science Center) Postdoctoral Fellowship – Development & Epigenetics (Centre National de la Recherche Scientifique) Postdoctoral Fellow – Hematopoietic Stem Cells (Memorial Sloan Kettering Cancer Center) Postdoctoral Positions – Stem Cell and Cancer Biology (Johns Hopkins University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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