Hematopoiesis News 9.00 January 2, 2018 | |
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TOP STORYInhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML Scientists found that acute myeloid leukemia (AML) progression leads to differential remodeling of vasculature in central and endosteal bone marrow regions. Endosteal AML cells produce pro-inflammatory and anti-angiogenic cytokines and gradually degrade endosteal endothelium, stromal cells, and osteoblastic cells, whereas central marrow remains vascularized and splenic vascular niches expand. [Cell Stem Cell] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors report that METTL14, a key component of the N6-methyladenosine (m6A) methyltransferase complex, is highly expressed in normal hematopoietic stem/progenitor cells and acute myeloid leukemia cells carrying t(11q23), t(15;17), or t(8;21) and is downregulated during myeloid differentiation. [Cell Stem Cell] Abstract | Graphical Abstract Donor T cell–derived tumor necrosis factor–α (TNFα) was specifically found to directly impair the survival and division of transplanted HSCs and progenitor cells. [Sci Transl Med] Abstract | Press Release Investigators showed that the impaired wound healing phenotype found in type 2 diabetes (T2D) mice is recapitulated in lethally irradiated wild type recipients, whose hematopoiesis is reconstituted with HSCs from T2D mice, indicating an HSC-autonomous mechanism. [Nat Commun] Full Article Scientists report that mice lacking hepatic leukemia factor are viable with essentially normal hematopoietic parameters, including an intact HSC pool during steady-state hematopoiesis. [Cell Rep] Full Article | Graphical Abstract Investigators applied in-depth quantitative proteomics to comprehensively describe and compare the proteome of fetal and adult hematopoietic stem and progenitor cells. [Cell Rep] Full Article | Graphical Abstract Researchers used Gata2Venus and Ly6a(SCA1)GFP reporter embryonic stem cells, derived from well-characterized mouse models of hematopoietic progenitor and stem cell emergence, to show that during in vitro differentiation they report emergent waves of primitive HPCs, definitive HPCs, and B-lymphoid cell potential. [Stem Cell Reports] Full Article ANP32A Dysregulation Contributes to Abnormal Megakaryopoiesis in Acute Megakaryoblastic Leukemia Scientists observed a potential correlation between ANP32A downregulation and megakaryocyte differentiation. HSCs and megakaryocyte-erythrocyte progenitor expressed a higher level of ANP32A than colony-forming unit-megakaryocyte and mature megakaryocytes, and significant upregulation of ANP32A was verified in primary acute megakaryoblastic leukemia cells. [Blood Cancer J] Full Article CLINICAL RESEARCHInvestigators conducted the first prospective study of the safety and efficacy of IV pentamidine for Pneumocystis jirovecii pneumonia (PJP) prophylaxis in adult patients undergoing hematopoietic stem cell transplant or intensive chemotherapy. [Bone Marrow Transplant] Abstract Scientists prospectively evaluated the impact of dimethyl sulfoxide (DMSO) concentration on engraftment after autologous peripheral blood stem cell transplantation. [Bone Marrow Transplant] Abstract | |
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REVIEWSThe authors describe the current understanding of the remodeling of the hematopoietic stem cell niche following invasion by leukemia cells. [Stem Cells] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSBioLineRx Ltd. announced initiation of the Phase III GENESIS clinical trial, in which BL-8040 will be compared to placebo, on top of granulocyte colony-stimulating factor, for the mobilization of HSCs used for autologous transplantation in multiple myeloma patients. [BioLineRx Ltd.] Press Release Seattle Genetics, Inc. announced that the FDA has accepted for filing a supplemental Biologics License Application for ADCETRIS in combination with chemotherapy for the frontline treatment of patients with advanced classical Hodgkin lymphoma. [Seattle Genetics, Inc.] Press Release Celgene Corporation and the Lymphoma Study Association announced that the Lymphoma Academic Research Organisation (LYSARC) reported results from a Phase III, randomized, open-label, international clinical study (RELEVANCE). [Celgene Corporation] Press Release | |
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POLICY NEWSNew NCI Director Expects Big Data to Revolutionize Cancer Research, Care Cancer researchers were nervous early this year about who President Donald Trump would choose to replace Harold Varmus as director of the National Cancer Institute (NCI). But their fears of an unconventional candidate proved unfounded when he tapped Norman “Ned” Sharpless. Sharpless, 51, who was then director of the Lineberger Comprehensive Cancer Center at the University of North Carolina in Chapel Hill. [ScienceInsider] Editorial Nobel Laureate Will Step Down from Leading Embattled Salk Institute Elizabeth Blackburn, the Nobel Prize–winning molecular biologist who took over just two years ago as president of the Salk Institute for Biological Studies in San Diego, California, announced her intent to retire next summer. The unexpected news comes as Salk faces gender discrimination lawsuits from three veteran female scientists and Blackburn herself has been challenged for not moving quickly enough to change what one plaintiff’s suit called an “old boys club” at the renowned research institute. [ScienceInsider] Editorial Chile Election Reignites Tussle over Science Policy Chile’s new President-elect Sebastián Piñera is poised to reshape science policy in the country. His plans to forge closer ties among science, education and industry have sparked enthusiasm from scientists who hope the plan will bolster support for their work — but also concern about possible changes in research priorities. [Nature News] Editorial Facebook Billionaire Pours Funds into High-Risk Research After his plan to test a cancer vaccine for middle-aged pet dogs was rejected by the US National Institutes of Health, inventor and biochemist Stephen Johnston sought funding outside the mainstream system. The Open Philanthropy Project, a grant-giving organization that is largely funded by Facebook co-founder Dustin Moskovitz and his wife Cari Tuna, announced that Johnston will receive US$6.4 million to test the vaccine he developed. [Nature News] Editorial
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EVENTSNEW The Stem Cell Niche Conference 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Hematology and Cancer Biology (University of Florida) NEW Investigator – Stem Cell Research (BloodCenter of Wisconsin) NEW Research Data Analyst – Hematology (National Institutes of Health) Postdoctoral Position – Hematopoiesis and Immunity (Lund University) Postdoctoral Scholarship – Hematology and Transfusion Medicine (Lund University) Postdoctoral Training Fellow – Hematopoiesis (The Francis Crick Institute) Staff Clinician – Hematology (National Heart, Blood and Lung Institute) Postdoctoral Scientist – Molecular Genetics of Human T Cell Development (Ghent University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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