Hematopoiesis News 9.13 April 3, 2018 | |
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TOP STORYA Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion Researchers defined a circular RNA that they named cia-cGAS that was highly expressed in the nucleus of long-term (LT)-HSCs. cia-cGAS deficiency in mice caused elevated expression of type I interferons in bone marrow and led to decreased numbers of dormant LT-HSCs. [Immunity] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Lipoprotein Lipase Regulates Hematopoietic Stem Progenitor Cell Maintenance through DHA Supply Scientists showed that lipoprotein lipase (LPL) activity is required for hematopoietic stem progenitor cell (HSPC) maintenance. Knockout of Lpl or its obligatory cofactor Apoc2 resulted in significantly reduced HSPC expansion during definitive hematopoiesis in zebrafish. [Nat Commun] Full Article Co-Targeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells Researchers assessed the efficacy of co-administration of the PI3K/mTOR inhibitor GDC-0980 or the p110β-sparing PI3K inhibitor taselisib with the selective BCL-2 antagonist venetoclax in acute myeloid leukemia (AML) cells. [Cancer Res] Abstract Stem Cell Defect in UBC-GFP Mice Facilitates Engraftment of Lymphoid-Primed Hematopoietic Stem Cells When investigators used UBC-green fluorescent protein (GFP) transgenic mice to study the availability of niches for transplanted hematopoietic stem and progenitor cells, the results were strikingly different from the corresponding experiments that used congenic mice polymorphic in the CD45 antigen. [Stem Cells] Abstract Researchers compared the erythrocyte’s structural parameters and selected metabolic indicators that are characteristic of the aging in microgravity and standard static incubation conditions. [Sci Rep] Full Article Intrauterine haemopoietic cell and gene therapies can potentially reduce perinatal morbidities with greater efficacy than postnatal therapy alone. The authors performed both procedures in the thalassemic HbbTh3/+ murine model. [Exp Hematol] Abstract CLINICAL RESEARCHScientists evaluated long-term complications in nearly all β-thalassemia-major patients who successfully received, in France, allogeneic hematopoietic stem cell transplantation. 99 patients were analyzed with a median age of 5.9 years at transplantation. [Haematologica] Abstract | Full Article The authors investigated rates and outcomes of antibiotic de-escalation during pre-engraftment neutropenia in allogeneic hematopoietic stem cell transplantation recipients. [Biol Blood Marrow Transplant] Abstract Researchers assessed the clinical role of donor-recipient Ehp disparity levels in patients by the population-based detection of human leukocyte antigen (HLA) allele phase mismatch. They found increased graft versus host disease (GvHD) incidences and mortality rates with increasing Ehp mismatch level even with the same HLA mismatch level. [Hum Immunol] Abstract | |
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REVIEWSCheckpoint Inhibitors and Acute Myelogenous Leukemia: Promises and Challenges Ongoing clinical trials in combination with HMAs are showing early promise, with doubling of response than that seen in historic controls. The optimal combinations of checkpoint inhibitors and the optimal space that they will fit in the continuum of acute myelogenous leukemia therapies need lot of in depth work. [Expert Rev Hematol] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSThe FDA granted accelerated approval to Blincyto to treat adults and children with B-cell precursor acute lymphoblastic leukemia who are in remission but still have minimal residual disease. [U.S. Food and Drug Administration] Press Release Nohla Therapeutics and WuXi AppTec Advanced Therapies have entered into a commercial agreement for production of Nohla’s NLA101, a universal donor, ex vivo expanded hematopoietic stem and progenitor cell product. [Nohla Therapeutics, Inc.] Press Release | |
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POLICY NEWSCancer Researchers Push to Relax Rules for Clinical Trials US government examines whether criteria for participating in drug studies unnecessarily exclude some people. [Nature News] Editorial EU Copyright Reforms Draw Fire from Scientists An influential committee of the European Parliament is due to vote on changes to copyright regulations in the European Union (EU), but the latest drafts of the rules have triggered a wave of criticism from open-science advocates. They say that the proposals will stifle research and scholarly communication. [Nature News] Editorial French Universities Cancel Subscriptions to Springer Journals French research organizations and universities have canceled their subscriptions to Springer journals, due to an impasse in fee negotiations between the publisher and Couperin.org, a national consortium representing more than 250 academic institutions in France. [The Scientist] Editorial In Emotional Speech, CDC’s New Leader Vows to Uphold Science Robert Redfield Jr., the new director of the Centers for Disease Control and Prevention (CDC), gave a deeply personal agency-wide address in which he repeatedly underscored the importance of science and data and said the CDC’s most critical public health mission is to protect Americans “from that which we don’t expect”. [The Washington Post] Editorial Cancer Researcher at the Ohio State University Resigns following Multiple Misconduct Findings A cancer researcher has resigned from The Ohio State University in Columbus after the institution determined he had committed misconduct in eight papers. His work in designing anticancer compounds had led to millions of dollars in funding and multiple patents, as well as two compounds in clinical trials. [ScienceInsider] Editorial
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EVENTSNEW 23rd Congress of European Hematology Association (EHA) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – Leukemia (St. Jude Children’s Research Hospital) Tenure Track Faculty Position – Hematopathology (University of Virginia) Postdoctoral Scholar – Clonal Hematopoiesis (Stanford University) Postdoctoral Fellow – Hematopoiesis and Hematopoietic Stem Cell Biology (City of Hope) Postdoctoral Position – Tregs in the Hematopoietic Stem Cell Niche (Columbia University) Postdoctoral Associate – Stem Cell Biology and Cancer Epigenetics (The Jackson Laboratory) Postdoctoral Fellow – Stem Cells, Development & Cancer (Albert Einstein College of Medicine) Postdoctoral Research Fellow – Hematopoiesis (Fred Hutchinson Cancer Research Center) Postdoctoral Positions – Hematopoietic Stem Cells (Memorial Sloan Kettering Cancer Center) Postdoctoral Associate – Stem Cell Biology (Duke University) Postdoctoral Fellowship – Functional Genomics of Human Hematopoiesis (Harvard Medical School) Postdoctoral Positions – Translational Leukemia (NYU Langone School of Medicine) Postdoctoral Research Associate – Mechanisms of Leukemia (University of Virginia) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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