Hematopoiesis News 9.50 December 18, 2018 | |
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TOP STORYScientists demonstrated that in early erythroid cells, heme increased ribosomal protein transcripts; suggesting that heme, in addition to upregulating globin transcription and translation, guarantees ample ribosomes for globin synthesis. In later erythroid cells, heme decreased GATA1, GATA1-target gene, and mitotic spindle gene expression. [Blood] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)SCL/TAL1 Cooperates with Polycomb RYBP-PRC1 to Suppress Alternative Lineages in Blood-Fated Cells Researchers documented temporally restricted co-expression of blood, cardiac and paraxial lineage-affiliated transcription factors in single cells, at the onset of blood specification, supporting the existence of common progenitors. [Nat Commun] Full Article By modeling acute myeloid leukemia (AML) in vivo investigators demonstrated that AML was discriminated by the age of the cell of origin. Young cells gave rise to myeloid, lymphoid or mixed phenotype acute leukemia, whereas adult cells gave rise exclusively to AML, with a shorter latency. [Nat Commun] Full Article | Press Release Decreased cell viability was demonstrated in murine chronic myeloid leukemia stem cells and human hematopoietic progenitor cells. RNA sequencing showed that blockade of HMGCLL1 was associated with G0/G1 arrest and the cell cycle. [Leukemia] Full Article The authors showed that TP53INP1 deletion had no impact on aging-related accumulation of HSCs. In contrast, the aging-related contraction of the lymphoid compartment was mitigated in TP53INP1 deficient (KO) mice. B cells that accumulated in old KO bone marrow were differentiating cells that could mature into functional B cells. [Proc Natl Acad Sci USA] Abstract Exogenous synthetic C2- and C6-ceramide as well as bacterial sphingomyelinase inhibited erythroid differentiation in erythropoietin-induced CD34+ HS/progenitor cells shown by the analysis of various erythroid markers. Moreover, sphingosine-1-phosphate, a ceramide metabolite, restored erythroid differentiation, whereas TNFα inhibited sphingosine kinase-1, required for S1P synthesis. [Cell Death Differ] Full Article Plasmodium falciparum Gametocyte-Infected Erythrocytes Do Not Adhere to Human Primary Erythroblasts Researchers investigated whether gametocyte-infected erythrocytes adhere to erythroid precursors, and whether a putative adhesion may be mediated by a mechanism similar to the adhesion of erythrocytes infected with P. falciparum asexual stages to uninfected erythrocytes. [Sci Rep] Full Article CLINICAL RESEARCHCD34+CD38− Leukemic Stem Cell Frequency to Predict Outcome in Acute Myeloid Leukemia Leukemic stem cell (LSC) containing CD34+CD38− fractions were measured using flow cytometry in an add-on study of the HOVON102/SAKK trial. Predefined cut-off levels were prospectively evaluated to assess CD34+CD38−LSC levels at diagnosis, and, to identify LSClow/LSChigh and MRDlow/MRDhigh patients in bone marrow in morphological complete remission. [Leukemia] Abstract In this prospective, multicentre study, patients undergoing autologous stem cell transplantation for relapsed/refractory lymphoma received peri-transplant involved-field radiotherapy to disease sites identified at study registration. Radiation dose was adapted to salvage chemotherapy response. Survival, relapse rates/pattern, toxicity, and prognostic factors were evaluated. [Int J Radiat Oncol Biol Phys] Abstract | Full Article Investigators retrospectively evaluated the outcome of allogeneic hematopoietic stem cell transplantation without posttransplantation cyclophosphamide in patients with adult T-cell leukemia-lymphoma registered in the Japan Society for Hematopoietic Cell Transplantation TRUMP database between 1985 and 2015. [Bone Marrow Transplant] Abstract Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News. | |
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REVIEWSThe Role of SRC Family Kinases in FLT3 Signaling The receptor tyrosine kinase FLT3 is expressed almost exclusively in the hematopoietic compartment. Several of the signal transduction pathways downstream of FLT3 have been shown to include various members of the SRC family of kinases (SFKs). The authors discuss some recent insights into how SFKs are involved in FLT3 signaling. [Int J Biochem Cell Biol] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSBristol-Myers Squibb Company announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has recommended the expanded approval of Sprycel, in combination with chemotherapy, to include the treatment of pediatric patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. [Bristol-Myers Squibb Company] Press Release Takeda Pharmaceutical Company Limited announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion for the extension of the marketing authorization of ADCETRIS and recommended its approval in combination with AVD in adult patients with previously untreated CD30+ stage IV hodgkin lymphoma. [Takeda Pharmaceutical Company Limited] Press Release Oncolytics Biotech® Inc. announced that the first patient was treated in a Phase I dose escalation study combining pelareorep and carfilzomib with Bristol-Myers Squibb’s checkpoint inhibitor Opdivo® to treat relapsed multiple myeloma patients. [Oncolytics Biotech® Inc.] Press Release Aptevo Therapeutics Inc. announced that the first patient has been dosed in a Phase I/Ib clinical trial of APVO436, a novel anti-CD123 by anti-CD3 bispecific antibody based on Aptevo’s ADAPTIR™ technology, which is being developed for the treatment of patients with Acute Myeloid Leukemia and High-Grade Myelodysplastic Syndrome. [Aptevo Therapeutics Inc.] Press Release Genmab A/S announced that Janssen Pharmaceutical K.K. has submitted a supplemental new drug application to the Ministry of Health, Labor and Welfare in Japan, for the use of daratumumab in combination with bortezomib, melphalan and prednisone for the treatment of patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant. [Genmab A/S] Press Release | |
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POLICY NEWSUniversities ‘Held Hostage’ in Nicaragua’s Political Crisis The repression has struck particularly hard at Nicaragua’s universities, where firings, arrests, and attacks on students have brought higher education and research to a virtual standstill. “The university system is being held hostage,” says María Luisa Acosta, a human rights lawyer and president of the Nicaraguan Academy of Sciences in Managua. [ScienceInsider] Editorial Spain to Establish Parliamentary Office of Science The decision follows a November meeting between parliamentarians and Science in the Parliament, a grassroots association of scientists and others with an interest in science, based in Madrid, that has campaigned for such a body. [Nature News] Editorial Steep Funding Cuts for Australian Science Announced Australia’s mid-year budget update, reveals that the country’s funding under so-called University Research Block Grants is to be slashed by $328.5 million AUD for the upcoming four years. The budget cuts are twice the amount Australian universities had expected. [The Scientist] Editorial Tenured Biology Professor Sacked for Research Misconduct The University of Illinois at Urbana-Champaign has fired former tenured biology professor, Fei Wang, after an investigation revealed he had falsified data on grant applications, The News-Gazette, reports. At a meeting on Friday (December 14), the university’s board of trustees made the final decision, effective immediately, to fire Wang. [The Scientist] Editorial
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EVENTSNEW 14th Annual Biomarkers Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESResearch Technologist – Hematopoietic (STEMCELL Technologies Inc.) Postdoctoral Scholar – Cancer Development (University of Southern California) Research Officer – Hematopoietic Stem Cells (The University of Queensland) Postdoctoral Position – Regenerative Medicine, Stem Cells and Bioengineering (Igenomix Foundation) Staff Scientist – Hematology (St. Jude Children’s Research Hospital) Assistant Project Scientist – Hematology and Oncology (University of California, Davis) Research Scientist – Hematological Malignancies (MD Anderson Cancer Center) Faculty Positions – Hematology and Oncology (UC Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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