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Vol. 12.04 – 02 February, 2021
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Researchers conducted a pooled CRISPR screen in human hematopoietic stem and progenitor cells that correlated ELANE mutations with neutrophil maturation potential.
[Cell Stem Cell]
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PUBLICATIONSRanked by the impact factor of the journal
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The authors identified the cell surface receptor neogenin-1 as specifically expressed in dormant HSCs. Loss of neogenin-1 initially leads to increased HSC expansion but subsequently to loss of self-renewal and premature exhaustion in vivo.
[Nature Communications]
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Scientists integrated in situ Hi-C and nine additional omics layers. Beyond conventional active and inactive compartments, they uncovered a highly-dynamic intermediate compartment enriched in poised and polycomb-repressed chromatin.
[Nature Communications]
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Investigators demonstrated for the first time that TGF-β-PAI-1 axis was selectively augmented in chronic myeloid leukemia (CML) in the bone marrow, whereby protecting CML-leukemia stem cells from tyrosine kinase inhibitor treatment.
[Haematologica]
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Scientists revealed that miR-21 deficiency markedly decreases the NF-κB pathway, accompanied by increased expression of PDCD4, a direct target of miR-21, in HSCs.
[Haematologica]
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The authors demonstrated that megakaryocytes possess a functional necroptosis signaling cascade. Necroptosis activation led to phosphorylation of mixed lineage kinase domain-like, loss of viability and cell swelling.
[Cell Death & Disease]
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Researchers generated CD34+ progenitor cells from two different embryonic stem cell lines, WA01 and WA09, to circumvent limitations associated with primary CD34+ hematopoietic progenitor cells.
[Journal of Virology]
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The authors describe the results of varying the proportion of bone marrow mesenchymal stem cells to CD34+ hematopoietic stem/progenitor cells co-seeded onto synthetic poly(1,8 octamethylene citrate) or small intestinal submucosa scaffolds and their contribution to bladder tissue regeneration.
[Scientific Reports]
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Investigators measured the radiation response of T cells, B cells, NK cells, CD34+ progenitor cells and monocytes obtained from peripheral blood and monocyte-derived macrophages and immature dendritic cells ex vivo and showed that T and B cells were highly sensitive, starting to undergo apoptosis following ionizing radiation with a dose as low as 0.125 Gy.
[Scientific Reports]
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When comparing the global gene expression of recently divided chronic lymphocytic leukemia cells with that of previously divided cells, researchers found higher levels of genes involved in regulating gene expression.
[Leukemia]
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Understanding how certain extra-oral pathologies are affected by disseminated periodontal pathogens and periodontitis-associated systemic inflammation, including adaptation of bone marrow hematopoietic progenitors, may provide new therapeutic options to reduce the risk of periodontitis-associated comorbidities.
[Nature Reviews Immunology]
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Investigators highlight how mitochondrial and metabolic pathways function as a central mediator to control gene expression, specifically on stem cell functions, differentiation and immune response in leukemia.
[Cancer Discovery]
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The Janssen Pharmaceutical Companies of Johnson & Johnson announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency will perform an accelerated assessment of the Marketing Authorisation Application for the B-cell maturation antigen-targeted chimeric antigen receptor T-cell therapy ciltacabtagene autoleucel.
[Janssen Pharmaceutical Companies of Johnson & Johnson]
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The International Society for Stem Cell Research (ISSCR) awarded the 2021 Tobias Lecture Award to Stuart H. Orkin, MD, Boston Children’s Hospital, Dana-Farber Cancer Institute, and Harvard Medical School. “Stuart is one of the most accomplished and innovative physician-scientists in the world engaged in hematopoiesis research,” said Christine Mummery, ISSCR President.
[The International Society for Stem Cell Research (EurekAlert!)]
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February 3 – 5, 2021
Virtual
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University of Oxford – Oxford, England, United Kingdom
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Blood Research Institute – Milwaukee, Wisconsin, United States
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The University of Texas MD Anderson Cancer Center – Houston, Texas, United States
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St. Jude Children’s Hospital – Memphis, Tennessee, United States
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Harvard Medical School – Boston, Massachusetts, United States
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News