 | | Vol. 14.07 – 21 February, 2023 |
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| Researchers developed a vectorized prime editing system that could directly repair the sickle cell disease (SCD) mutation in HSCs in vivo in an SCD mouse model.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators found that adenosine deaminase acting on RNA 2 (ADAR2), but not ADAR1 and ADAR3, was specifically downregulated in the core binding factor AML with t(8;21) or inv(16) translocations.
[Blood] |
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| Scientists integrated existing molecular subtyping approach for myeloid malignancies based on RNA-Seq with analysis of miRNA expression in high- and low-AML prognostic score AML cases, to better understand how dysregulation of the non-coding transcriptome contributes to disease pathogenesis.
[Leukemia] |
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| Researchers identified an Aeromonas veronii strain with immuno-modulatory activities that failed to induce hematopoietic stem and progenitor cell (HSPC) development in wild-type fish but selectively inhibited kidney cytokine expression and rebalanced HSPC development in chd8−/− zebrafish.
[Cell Reports] |
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| Scientists evaluated cord blood-derived endothelial progenitor cells as a potential cellular therapy for mitigation of hematologic acute radiation syndrome.
[International Journal Of Radiation Oncology Biology Physics] |
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| Investigators identified potential mechanisms of chemoresistance of the “7+3” induction in AML by using a single-cell RNA sequencing approach.
[Hematological Oncology] |
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| Scientists conducted a multi-center study to analyze factors predicting survival among patients with TP53-mutated AML receiving allogeneic hematopoietic stem cell transplant in the recent era.
[Leukemia] |
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| Researchers evaluated the outcome in a homogenous group of patients who underwent second allogeneic hematopoietic stem cell transplantation AML only, with the main focus on the reason for treatment failure and relapse.
[Polish Archives Of Internal Medicine-Polskie Archiwum Medycyny Wewnetrznej] |
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| Scientists retrospectively studied data from five Italian centers and identified 20 patients that attempted HSC mobilization after fractionated doses of GO + “7 + 3” regimen and one–two cycles of consolidation.
[Annals Of Hematology] |
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| The authors provide an update on HSC-intrinsic and HSC-extrinsic factors and processes recently discovered to contribute to the functional decline of HSCs during aging.
[Blood] |
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| 17 projects across the University of Connecticut (UConn) and UConn Health would receive a total of $729,000 in funding through the Clinical Research and Innovation Seed Program.
[University of Connecticut] |
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| IASO Biotherapeutics (IASO Bio) announced that the US FDA granted both RMAT designation and FT designation to its investigational new drug BCMA CAR-T CT103A, Equecabtagene Autoleucel, for relapsed/refractory multiple myeloma.
[IASO Biotherapeutics] |
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| March 5 – 9, 2023
Banff, Alberta, Canada |
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| | University of Maryland – Baltimore, Maryland, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Johns Hopkins University – Baltimore, Maryland, United States |
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| | Loughborough University – Leicestershire, England, United Kingdom |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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