Hepatic Cell New Volume 5.14 | Apr 23 2021

May 12, 2022

Hepatic Cell News by STEMCELL Technologies

Vol. 5.14 – 23 April, 2021

TOP STORY

Nuclear Receptors FXR and SHP Regulate Protein N-Glycan Modifications in the Liver

Scientists describe a previously unknown function for the hepatic farnesoid X receptor (FXR)-small heterodimer partner (SHP) axis in controlling protein N-linked glycosylation.
[Science Advances]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

Glucose Deprivation Induced Aberrant FUT1-Mediated Fucosylation Drives Cancer Stemness in Hepatocellular Carcinoma

Using hepatocellular carcinoma as a model, scientists showed that restricted glucose availability enhanced the PERK-eIF2α-ATF4 signaling axis to drive fucosyltransferase-1 (FUT1) transcription via direct binding of ATF4 to the FUT1 promoter.
[Journal of Clinical Investigation]

Abstract

Chitinase 3-Like 1 Is a Profibrogenic Factor Overexpressed in the Aging Liver and in Patients with Liver Cirrhosis

Investigators hypothesized that the pace of fibrosis progression might reflect changes in gene expression within the aging liver.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

27-Hydroxycholesterol Is a Specific Factor in the Neoplastic Microenvironment of HCC That Causes MDR via GRP75 Regulation of the Redox Balance and Metabolic Reprogramming

Scientists found that by inducing an increase in oxidative stress signaling, 27-hydroxycholesterol activated glucose-regulated protein 75 (GRP75).
[Cell Biology and Toxicology]

Abstract

Hepatic Differentiation of Human Embryonic Stem Cells by Coupling Substrate Stiffness and Microtopography

Researchers implied that the coupling of substrate stiffness and topography, combined with the biochemical signals, was favorable to improve the efficiency and functionality of hepatic differentiation of human embryonic stem cells.
[Biomaterials Science]

Abstract Graphical Abstract

HBx Promotes Hepatocarcinogenesis by Enhancing Phosphorylation and Blocking Ubiquitinylation of UHRF2

Scientists investigated the connection and mechanism between UHRF2 and HBV-associated hepatocellular carcinoma.
[Hepatology International]

Abstract

Cholesterol-Binding Translocator Protein TSPO Regulates Steatosis and Bile Acid Synthesis in Non-Alcoholic Fatty Liver Disease

Loss of translocator protein in hepatocytes in vitro downregulated acetyl-CoA acetyltransferase 2 and increased free cholesterol.
[iScience]

Abstract Graphical Abstract

Integrin αVβ1 Regulates Procollagen I Production through a Non-Canonical Transforming Growth Factor β Signaling Pathway in Human Hepatic Stellate Cells

Based on mRNA and protein expression profiling data, investigators found that αVβ1 integrin is the most abundant member of the αV integrin family in either quiescent or transforming growth factor β1-activated primary human hepatic stellate cells.
[Biochemical Journal]

Abstract

Long Non-Coding RNA Muskelin 1 Antisense RNA (MKLN1-AS) Is a Potential Diagnostic and Prognostic Biomarker and Therapeutic Target for Hepatocellular Carcinoma

Researchers investigated the detailed biological role of MKLN1-AS and Yes-associated transcriptional regulator 1-related mechanisms.
[Experimental and Molecular Pathology]

Abstract

Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.

REVIEWS

Liver-Targeting Drugs and Their Effect on Blood Glucose and Hepatic Lipids

The authors review the metabolic effects of drugs in relation to improvement of diabetic hyperglycaemia and fatty liver disease, as well as peripheral metabolism and insulin resistance.
[Diabetologia]

Full Article

The Interplay of microRNAs and Transcription Factors in Autophagy Regulation in Nonalcoholic Fatty Liver Disease

Researchers summarize the microRNAs and transcription factors that regulate the autophagy pathway in nonalcoholic fatty liver disease.
[Experimental and Molecular Medicine]

Full Article

INDUSTRY AND POLICY NEWS

Brii Biosciences, Vir Biotechnology, and VBI Vaccines Announce Initiation of Phase 2 Clinical Trial of BRII-835 (VIR-2218) in Combination with BRII-179 (VBI-2601) for the Treatment of Hepatitis B

Brii Biosciences, Vir Biotechnology, Inc., and VBI Vaccines Inc. announced that the first patient had been dosed in a Phase II clinical trial evaluating BRII-835, an investigational small interfering ribonucleic acid targeting hepatitis B virus (HBV) , in combination with BRII-179, an investigational HBV immunotherapeutic, for the treatment of chronic HBV infection.
[Vir Biotechnology, Inc.]

Press Release

Aligos Therapeutics Begins Dosing with Capsid Assembly Modulator Drug Candidate, ALG-000184, in First Cohort of Chronic Hepatitis B Patients in a Phase I Proof-of-Concept Study

Aligos Therapeutics, Inc. announced that the company has started dosing in the first cohort of chronic hepatitis B patients in the ongoing ALG-000184-201 study.
[Aligos Therapeutics, Inc.]

Press Release

FEATURED EVENT

Nuclear Receptors FXR and SHP Regulate Protein N-Glycan Modifications in the Liver

Glucose Deprivation Induced Aberrant FUT1-Mediated Fucosylation Drives Cancer Stemness in Hepatocellular Carcinoma

Chitinase 3-Like 1 Is a Profibrogenic Factor Overexpressed in the Aging Liver and in Patients with Liver Cirrhosis

27-Hydroxycholesterol Is a Specific Factor in the Neoplastic Microenvironment of HCC That Causes MDR via GRP75 Regulation of the Redox Balance and Metabolic Reprogramming

Hepatic Differentiation of Human Embryonic Stem Cells by Coupling Substrate Stiffness and Microtopography

HBx Promotes Hepatocarcinogenesis by Enhancing Phosphorylation and Blocking Ubiquitinylation of UHRF2

Cholesterol-Binding Translocator Protein TSPO Regulates Steatosis and Bile Acid Synthesis in Non-Alcoholic Fatty Liver Disease

Integrin αVβ1 Regulates Procollagen I Production through a Non-Canonical Transforming Growth Factor β Signaling Pathway in Human Hepatic Stellate Cells

Long Non-Coding RNA Muskelin 1 Antisense RNA (MKLN1-AS) Is a Potential Diagnostic and Prognostic Biomarker and Therapeutic Target for Hepatocellular Carcinoma

Liver-Targeting Drugs and Their Effect on Blood Glucose and Hepatic Lipids

The Interplay of microRNAs and Transcription Factors in Autophagy Regulation in Nonalcoholic Fatty Liver Disease

Brii Biosciences, Vir Biotechnology, and VBI Vaccines Announce Initiation of Phase 2 Clinical Trial of BRII-835 (VIR-2218) in Combination with BRII-179 (VBI-2601) for the Treatment of Hepatitis B

Aligos Therapeutics Begins Dosing with Capsid Assembly Modulator Drug Candidate, ALG-000184, in First Cohort of Chronic Hepatitis B Patients in a Phase I Proof-of-Concept Study

World Stem Cell Summit

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Research Assistant – Liver Immunology

Associate Editor – Gastroenterology & Hepatology

Postdoctoral Fellow – Liver Diseases

Research Assistant – Liver Regeneration & Tissue Engineering

Oligonucleotide Biologist – Liver, Central Nervous System, and Eye

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