Hepatic Cell New Volume 5.15 | Apr 30 2021

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    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.15 – 30 April, 2021
    TOP STORY

    EPHB2
    Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma

    Scientists established two sorafenib-resistant, patient-derived tumor xenografts that mimicked development of acquired resistance to sorafenib in hepatocellular carcinoma patients.
    [Cancer Research]

    Abstract
    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Glucocorticoid-Induced
    Leucine Zipper Regulates Liver Fibrosis by Suppressing CCL2-Mediated Leukocyte Recruitment

    Investigators found that glucocorticoid-induced leucine zipper deficiency in mice was associated with elevated CCL2 production and pro-inflammatory leukocyte infiltration at the early liver fibrosis (LF) stage, resulting in enhanced LF development.
    [Cell Death & Disease]

    Full Article

    GSTZ1
    Sensitizes Hepatocellular Carcinoma Cells to Sorafenib-Induced Ferroptosis via Inhibition of NRF2/GPX4 Axis

    Researchers investigated the role and underlying molecular mechanisms of glutathione S-transferase zeta 1 (GSTZ1) in sorafenib-induced ferroptosis in hepatocellular carcinoma.
    [Cell Death & Disease]

    Full Article

    SAA1/TLR2
    Axis Directs Chemotactic Migration of Hepatic Stellate Cells Responding to Injury

    Scientists demonstrated that serum amyloid A1 (SAA1) acted as a chemokine recruiting hepatic stellate cells towards injury loci signaling via TLR2, a finding proven by gene manipulation studies in cell and mice models.
    [iScience]

    AbstractGraphical Abstract

    Targeting
    Smyd3 by Next Generation Antisense Oligonucleotides Suppresses Liver Tumor Growth

    Researchers showed that targeting Smyd3 by next-generation antisense oligonucleotides was an efficient approach to modulate its mRNA levels in vivo and to halt the growth of already initiated liver tumors.
    [iScience]

    AbstractGraphical Abstract

    Dietary
    Essential Amino Acid Restriction Promotes Hyperdipsia via Hepatic FGF21

    Scientists showed that the dietary protein dilution effects on hyperdipsia were induced by the deprivation of threonine and tryptophan, and in turn, via liver/hepatocyte-derived FGF21.
    [Nutrients]

    Abstract

    Discovery,
    Optimization, and Evaluation of Non-Bile Acid FXR/TGR5 Dual Agonists

    Investigators discovered potent non-bile acid FXR/TGR5 dual agonists and identified some non-bile acid FXR/TGR5 dual agonists, such as isonicotinamide derivatives in vitro assay.
    [Scientific Reports]

    Full Article

    Direct
    Conversion of Porcine Primary Fibroblasts into Hepatocyte-Like Cells

    Scientists demonstrated for the first time, hepatic conversion of porcine somatic cells by over-expression of CEBPα, FOXA1 and HNF4α2.
    [Scientific Reports]

    Full Article

    Ubiquitin
    Specific Peptidase 1 Promotes Hepatic Fibrosis through Positive Regulation of CXCL1 by Deubiquitinating SNAIL

    Researchers investigated the expression status of ubiquitin specific peptidase 1 and its potential mechanisms on hepatic stellate cells and hepatic fibrosis.
    [Digestive and Liver Disease]

    Abstract
    In this webinar on hepatic organoids review the biological characteristics and practical considerations of adding organoids to your research.
    REVIEWS

    The
    Therapeutic Landscape of Hepatocellular Carcinoma

    Scientists shed light into the current therapeutic landscape of hepatocellular carcinoma with an emphasis on the available treatments, ranging from surgical and local-ablative therapy for early and intermediate stages of the disease to systemic therapies for advanced cancer treatments.
    [Med]

    Full Article

    INDUSTRY AND POLICY NEWS

    Homology Medicines Announces New Approach to Leverage AAVHSC Platform by Delivering One-Time In Vivo Gene Therapy to Produce Antibodies in Humanized Murine Model

    Homology Medicines, Inc. announced a new approach to its AAVHSC platform that delivered one-time gene therapy to produce antibodies throughout the body.
    [Homology Medicines, Inc.]

    Press Release

    Mirum Pharmaceuticals and CANbridge Pharmaceuticals Enter into Exclusive Licensing Agreement to Develop and Commercialize Maralixibat in Greater China for Rare Liver Diseases

    Mirum Pharmaceuticals, Inc. and CANbridge Pharmaceuticals, Inc., announced that they have entered into a licensing agreement, pursuant to which CANbridge has agreed to develop and commercialize maralixibat in Greater China.
    [Mirum Pharmaceuticals, Inc. and CANbridge Pharmaceuticals, Inc. (Business Wire, Inc.)]

    Press Release
    FEATURED EVENT

    ISSCR:
    Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Tokyo, Japan


    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Hepatitis B Virus Replication and Host Interactions

    University of Wisconsin-Madison – Madison, Wisconsin, United States

    Research Assistant – Liver Immunology

    Institute of Hepatology – London, United Kingdom

    Associate Editor – Gastroenterology & Hepatology

    Springer Nature – London, United Kingdom

    Postdoctoral Fellow – Liver Diseases

    University of Illinois – Chicago, Illinois, United States


    Oligonucleotide Biologist – Liver, Central Nervous System, and Eye

    Deep Genomics, Inc. – Toronto, Ontario, Canada

    >
    See All Jobs

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