Hepatic Cell New Volume 5.16 | May 7 2021

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    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.16 – 7 May, 2021
    TOP STORY

    A Kinome Screen Reveals That Nemo-Like Kinase Is a Key Suppressor of Hepatic Gluconeogenesis

    Using a gluconeogenesis-targeted kinome screening approach combined with transcriptome analyses, scientists uncovered Nemo-like kinase as a potent suppressor of hepatic gluconeogenesis (HGP).
    [Cell Metabolism]

    AbstractGraphical Abstract

    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    PUBLICATIONSRanked by the impact factor of the journal

    Adenine Base Editing and Prime Editing of Chemically Derived Hepatic Progenitors Rescue Genetic Liver Disease

    Researchers reprogrammed hepatocytes from a mouse model of hereditary tyrosinemia type 1 into expandable CdHs and successfully corrected the disease-causing mutation using both adenine base editors and prime editors.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    A Mutation in SLC37A4 Causes a Dominantly Inherited Congenital Disorder of Glycosylation Characterized by Liver Dysfunction

    Scientists generated a CRISPR base-edited hepatoma cell line harboring the c.1267C>T variant. These cells replicated the secreted abnormalities seen in serum N-glycosylation, and a portion of the mutant protein appeared to relocate to a distinct, non-golgi compartment, possibly endoplasmic reticulum exit sites.
    [American Journal of Human Genetics]

    Abstract

    Supramolecular Self-Assembled Nanofibers Efficiently Activate the Precursor of Hepatocyte Growth Factor for Angiogenesis in Myocardial Infarction Therapy

    Investigators designed supramolecular nanofibers self-assembled by compound 1, which could strongly activate the hepatocyte growth factor precursor and initiate hepatocyte growth factor–Met signaling.
    [ACS Applied Materials & interfaces]

    Abstract

    Tspan5 Promotes Epithelial-Mesenchymal Transition and Tumor Metastasis of Hepatocellular Carcinoma by Activating Notch Signaling

    Mechanistic studies revealed that Tspan5 promoted cell migration and tumor metastasis by increasing the enzymatic maturation of ADAM10 and activating Notch signaling via the increase of the cleavage of the Notch1 receptor catalyzed by the γ‐secretase complex.
    [Molecular Oncology]

    Abstract

    Morphine May Act via DDX49 to Inhibit Hepatocellular Carcinoma Cell Growth

    Scientists showed that morphine could inhibit hepatocellular carcinoma (HCC) cell proliferation. They further showed that DEAD-box helicase 49 (DDX49 ) was up-regulated in HCC tumors, and that knocking down the DDX49 gene decreases tumor formation in vivo and in vitro, as well as reduces tumor metastasis in vivo.
    [Aging]

    Full Article

    Histone Deacetylase Inhibitor Resminostat in Combination with Sorafenib Counteracts Platelet-Mediated Pro-Tumoral Effects in Hepatocellular Carcinoma

    The impact of platelets on the sorafenib and resminostat drug effects in hepatocellular carcinoma cells was explored. In contrast to sorafenib, resminostat triggered an anti-proliferative response in hepatocellular carcinoma cell lines independent of platelets.
    [Scientific Reports]

    Full Article

    Macrophage Potentiates the Recovery of Liver Zonation and Metabolic Function after Acute Liver Injury

    Researchers employed a mouse model of carbon tetrachloride induced-acute liver injury with clodronate-induced macrophage depletion to clarify the impact of liver injury on liver metabolism and recovery dynamics of metabolic function and liver zonation during regeneration.
    [Scientific Reports]

    Full Article

    Improving the Translation of Organic Anion Transporting Polypeptide Substrates Using HEK293 Cell Data in the Presence and Absence of Human Plasma via PBPK Modeling

    Scientists used physiologically based pharmacokinetic modeling to understand the translational accuracy of data generated with human embryonic kidney (HEK)293 cells overexpressing the hepatic uptake transporters OATP1B1/3 with and without plasma, while accounting for transporter expression.
    [Drug Metabolism and Disposition]

    Abstract

    Guide to everything you need to know about cell separation.
    REVIEWS

    Genomic Landscape of Hepatocarcinogenesis

    The recent genetic analysis uncovered a distinctive driver gene landscape in precancerous lesions, arguing a discontinuous process at early hepatocellular carcinoma development.
    [Journal of Human Genetics]

    Abstract

    INDUSTRY AND POLICY NEWS

    IMFINZI and Tremelimumab with Chemotherapy Demonstrated Overall Survival Benefit in POSEIDON Trial for 1st-Line Stage IV Non-Small Cell Lung Cancer

    POSEIDON was a Phase III trial of AstraZeneca’s IMFINZI® plus platinum-based chemotherapy or IMFINZI, tremelimumab and chemotherapy versus chemotherapy alone in the first-line treatment of patients with Stage IV non-small cell lung cancer.
    [Business Wire, Inc.]

    Press Release

    NovoBiome Launched to Revolutionize Treatment of Liver Diseases by Targeting the Microbiome-Gut-Liver Axis

    NovoBiome, Inc. launched to revolutionize treatment of liver diseases by targeting the microbiome-gut-liver axis.
    [NovoBiome, Inc. (Globenews Wire, Inc.)]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Cancer Immunometabolism

    November 29 – December 1, 2021
    Barcelona, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Fatty Liver and Diabetes

    Albert Einstein College of Medicine – Bronx, New York, United States

    Director – Liver Disease

    The Griffin Institute – Harrow, United Kingdom

    Postdoctoral Research Associate – Hepatitis B Virus Replication and Host Interactions

    University of Wisconsin-Madison – Madison, Wisconsin, United States

    Postdoctoral Fellow – Liver Diseases

    University of Illinois – Chicago, Illinois, United States

    Oligonucleotide Biologist – Liver, Central Nervous System, and Eye

    Deep Genomics, Inc. – Toronto, Ontario, Canada

    > See All Jobs

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