Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News| Hepatic Cell News 1.29 August 18, 2017 | |
 | |
| |
TOP STORYScientists showed that knockdown of taurine upregulated gene 1 induces marked inhibition of cell migration, invasion and glycolysis via suppression of miR-455-3p. miR-455-3p, which is transcriptionally repressed by p21, directly targeted the 3′-untranslated region of AMP-activated protein kinase subunit beta 2. [Hepatology] Abstract | |
| |
| |
PUBLICATIONS(Ranked by impact factor of the journal)The role of HOXD-AS1 in hepatocelluar carcinoma (HCC) cells was assessed both in vitro and in vivo. Knockdown of HOXD-AS1 significantly inhibited migration and invasion of HCC cells in vitro and distant lung metastasis in vivo. [Mol Cancer] Full Article Quantitative PCR was used to evaluate the level of miR-1301 expression in hepatocelluar carcinoma (HCC) tissues and cell lines. Transwell and tube-formation assays were used to measure the effects of miR-1301 on HCC cell migration and invasion, and angiogenesis, respectively. [Cell Death Dis] Full Article Inhibition of Connexin Hemichannels Alleviates Non-Alcoholic Steatohepatitis in Mice Researchers investigated whether connexin32 and connexin43 hemichannels play a role in non-alcoholic steatohepatitis. Transactivator of transcription (TAT)-Gap24 and TAT-Gap19 were shown to be hemichannel-specific in cultured primary hepatocytes. [Sci Rep] Full Article The authors used HepG2 and Hep3B cell lines to investigate the cytotoxic effects of 2,4,6-trinitrotoluene (TNT). They found that TNT significantly decreased cell viability and induced DNA damage. Through transcriptomic analysis, they observed that the diverse biological functions affected included mitochondrial dysfunction and endoplasmic reticulum stress. [Sci Rep] Full Article Scientists investigated the effects of hepatic nuclear factor (HNF) 4α on the proliferation, migration, and maltransformation of hepatic progenitors and determined the feasibility of using these manipulated cells for transplantation. [Stem Cell Res Ther] Full Article Role of IQGAP3 in Metastasis and Epithelial-Mesenchymal Transition in Human Hepatocellular Carcinoma Investigators determined the biological role and molecular mechanism of IQ motif-containing GTPase activating protein 3 (IQGAP3) in hepatocellular carcinoma (HCC). Ectopic expression of IQGAP3 markedly enhanced HCC cell migration, invasion, and epithelial-to-mesenchymal transition in vitro and promoted metastasis of orthotopic hepatic tumors in nude mice. [J Transl Med] Full Article The Expression of ETAR in Liver Cirrhosis and Liver Cancer Immunofluorescence was used to locate ETAR expression in hepatic stellate cells and hepatic sinusoidal endothelial cells. Researchers calculated the percentage of positive cells and then analyzed its relation with clinical indexes. [Cancer Biol Ther] Abstract Regulation of Hepatic Stellate Cell Proliferation and Activation by Glutamine Metabolism The authors report a novel pathway to control hepatic stellate cells (HSCs) by regulating glutamine metabolism. They demonstrated that the proliferation of HSCs is critically dependent on glutamine that is used to generate α-ketoglutarate and non-essential amino acid. [PLoS One] Full Article | |
| |
| |
REVIEWSMechanisms of Hepatitis B Virus Persistence Studies in recent years have significantly improved our knowledge on the mechanisms of hepatitis B Virus (HBV) persistence. HBV uses multiple pathways to harness host innate immunity to enhance its replication. [Trends Microbiol] Abstract Visit our reviews page to see a complete list of reviews in the hepatic cell research field. | |
| |
INDUSTRY NEWSFDA Grants Lion TCR Two Orphan Drug Designations of T Cell Therapy against Hepatocellular Carcinoma US FDA has granted two orphan drug designations for T cell therapy products to Singapore-based biotech company, Lion TCR Pte Ltd, for the treatment of hepatocellular carcinoma. [Lion TCR Pte Ltd. (PR Newswire Association LLC.)] Press Release SillaJen, Inc. announced that it has entered into a Cooperative Research and Development Agreement with the National Cancer Institute for the development of a combination therapy for colorectal cancer. Pexa-Vec is currently being evaluated in a worldwide Phase III clinical trial for advanced primary liver cancer. [SillaJen, Inc. (PR Newswire Association LLC.)] Press Release | |
| |
POLICY NEWSChina’s Embrace of Embryo Selection Raises Thorny Questions Fertility centers are making a massive push to increase preimplantation genetic diagnosis in a bid to eradicate certain diseases. [Nature News] Editorial NSF Reiterates Policy on Teaching Good Research Habits despite Its Limitations The National Science Foundation (NSF) in Arlington, Virginia, has decided to double down on its implementation of a congressionally mandated policy aimed at reducing research misconduct among NSF-funded scientists, despite a new report that notes problems with the agency’s approach. [ScienceInsider] Editorial Trump’s First List of Science Priorities Ignores Climate—and Departs from His Own Budget Request President Donald Trump has translated his campaign promise to “make America great again” into his administration’s first blueprint for federal investment in science and technology. [ScienceInsider] Editorial New FDA Security Rules Will Bar Agency from Hiring Some Foreign Nationals The FDA is moving to adopt a new policy on security background checks that is sowing confusion and alarm among some of its scientists. The change, described in a “communications plan” shared with the agency’s senior staff in recent weeks, appears to effectively bar the agency from hiring—as employees or contractors—foreign nationals who have not lived in the United States for a total of three out of the last five years. [ScienceInsider] Editorial
| |
EVENTSNEW EACR-MRS: Seed and Soil: In Vivo Models of Metastasis Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Research Associate – Hepatitis B Virus Pathogenesis (Imperial College London) NEW Research Scientist – Chronic Fibrotic and Metabolic Diseases (Gilead Sciences, Inc.) Senior Lab Manager – Notch Control of Liver Development (Karolinska Institutet) Research Fellows – Cancer Research (National University of Singapore) Multiple Positions – Cancer Research (National University of Singapore) Assistant Professor – Biomedical Research (National Institutes of Health) Postdoctoral Scholar – Computational Biology/Cancer Genomics (University of Chicago) Postdoctoral Fellow – Stem Cell Biology (University of Louisville) Postdoctoral Research Fellow – Pathogenesis of Metabolic Diseases (Columbia University) Postdoctoral or PhD Position – Cancer Research (University Medical Center Groningen) Senior Investigator/Investigator – Molecular Pathology (Novartis Institutes for BioMedical Research) Academic Pathologist – Liver/GI (University of Texas Southwestern Medical Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Hepatic Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|
