Hepatic Cell News 3.02 January 25, 2019 | |
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TOP STORYThe Circadian Clock Components BMAL1 and REV-ERBα Regulate Flavivirus Replication Scientists demonstrated that the circadian components BMAL1 and REV-ERBα influence several steps in the hepatitis C virus life cycle, including particle entry into hepatocytes and RNA genome replication. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists found that the upregulation of Rpn10 in hepatocellular carcinoma (HCC) was associated with poor prognosis. The ectopic overexpression of Rpn10 increased HCC cell proliferation, whereas silencing Rpn10 expression resulted in decreased cell proliferation. [Cancer Lett] Abstract Engineered Relaxin as Theranostic Nanomedicine to Diagnose and Ameliorate Liver Cirrhosis PEGylated superparamagnetic iron-oxide nanoparticles (RLX-SPIONs) showed specific binding and uptake in TGFβ-activated hepatic stellate cells (HSCs), and inhibited TGFβ-induced HSCs differentiation, migration and contraction. In vivo, RLX-SPIONs strongly attenuated cirrhosis and showed enhanced contrast in MR imaging. [Nanomedicine] Full Article | Graphical Article SVIP Alleviates CCl4-Induced Liver Fibrosis via Activating Autophagy and Protecting Hepatocytes Autophagy could be activated by small VCP/p97 interacting protein (SVIP) in HepG2 cells, but starvation could not increase SVIP expression in vitro and in vivo. Moreover, SVIP expression, in agreement with autophagic activity and the volume of lipid droplets, first increased and then decreased during the progression of liver fibrosis with CCl4 treatment in vivo and in vivo. [Cell Death Dis] Full Article Transfection of CDH-GATA5 vectors into hepatocellular carcinoma (HCC) cells increased the GATA5 expression and decreased the expression of β-catenin and reprogramming genes p-Oct4, Nanog, Klf4, c-myc and EpCAM. Increased GATA5 expression by transfection with its expression vectors was also able to inhibit the cell growth, colony formation and capability of migration, invasion, while promoting apoptosis in HCC cells. [J Cell Mol Med] Full Article Human fibrosis microarrays conducted using primary macrophages (LX-2) cell RNA derived from MLH co-culture conditions, with or without hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infection, revealed novel insights regarding the roles of these viral infections on fibrogenic gene expression in LX-2 cells. [Sci Rep] Full Article Investigators showed the expression of SH3 protein 1 antisense (LASP1-AS) correlated positively with LASP1 expression in hepatocellular carcinoma (HCC) tissues. LASP1-AS promoted the proliferation, migration, and invasion abilities of HCC in vitro and vivo by enhancing LASP1 expression. [J Cell Physiol] Abstract Gain- and loss-of function experiments showed the oncogenic action of frizzled 2 (FZD2) in hepatocellular carcinoma (HCC) cell proliferation, apoptosis, migration, and invasion. Further investigations in vitro and in vivo suggested that FZD2 promoted the epithelial-mesenchymal transition process, enhanced stem-like properties, and conferred vasculogenic mimicry capacity to HCC cells. [Cancer Sci] Abstract Human Primary Liver Cancer Organoids Reveal Intratumor and Interpatient Drug Response Heterogeneity The authors evaluated functional heterogeneity in a cohort of primary human liver cancer organoid lines. Each primary human liver cancer surgical specimen was used to generate multiple cancer organoid lines, obtained from distinct regions of the tumor. [JCI Insight] Full Article Subscribe to one of our other 19 science newsletters such as Intestinal Cell News & Pancreatic Cell News. | |
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REVIEWSGut Microbial Metabolites in Obesity, NAFLD and T2DM The authors focus on the role of products derived from microbial carbohydrate and protein fermentation in relation to obesity and obesity-associated insulin resistance, type 2 diabetes mellitus and nonalcoholic fatty liver disease, and discuss the mechanisms involved. [Nat Rev Endocrinol] Abstract Visit our reviews page to see a complete list of reviews in the hepatic cell research field. | |
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INDUSTRY NEWSSTEMCELL Technologies has released mTeSR™ Plus, an enhanced version of mTeSR™1, the most widely published feeder-free human pluripotent stem cell maintenance medium. The new medium has undergone successful beta testing with several members of the Stem Cell COREdinates group and has completed rigorous in-house validation testing. [STEMCELL Technologies Inc] Press Release Albireo Pharma, Inc. announced the U.S. FDA has granted orphan drug designation to lead product candidate A4250, an ileal bile acid transporter inhibitor, for the treatment of biliary atresia, a rare and life-threatening liver disease with no approved pharmacologic treatment option. [Albireo Pharma, Inc.] Press Release Cocrystal Pharma, Inc. announced safety and preliminary efficacy data for its U.S. Phase IIa study evaluating CC-31244 for the ultra-short treatment of hepatitis C Virus infected individuals. [COCRYSTAL PHARMA, INC] Press Release SciCann Therapeutics Launch Liver Disease Research Program in Tel Aviv University SciCann Therapeutics announced that it has launched a novel sponsored research program in Tel Aviv University, focused on the field of liver diseases. The new research program is designed to explore the efficacy of SciCann’s line of proprietary, cannabinoid-based, anti-inflammatory combination products for the treatment of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis. [SciCann Therapeutics (GlobeNewswire, Inc.)] Press Release Nash Pharmaceuticals Inc., announced that its lead compound for non-alcoholic steatohepatitis NP-160 showed repeated positive results in a recently completed study investigating its therapeutic effects in the widely used STAM™ mouse model from SMC Laboratories. In addition, a second compound, NP-135 was identified as an additional lead. [Breathtec Biomedical Inc] Press Release | |
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POLICY NEWSScientists Relieved but Wary as US Shutdown Nears End The US government is poised to re-open after a historic 34-day shutdown that has paralyzed the National Science Foundation, NASA and other key science agencies. [Nature News] Editorial CRISPR-Baby Scientist Fired by University The scientist who announced last year that he had produced the world’s first gene-edited babies has been fired by his university. [Nature News] Editorial
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EVENTSNEW Keystone Symposia: Cancer Stem Cells: Advances in Biology & Clinical Translation Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Non-Alcoholic SteatoHepatitis (University of Southern Denmark) NEW Postdoctoral Researcher – Cancer Biology (University of California, San Francisco) Senior Scientific Officer – Cancer Biology (Cancer Research UK Beatson Institute) Postdoctoral Researcher – Cancer Biology (University of Pennsylvania – Perelman School of Medicine) Postdoctoral Position – Nonalcoholic Steatohepatitis (University of Southern Denmark) PhD Position – Cancer Biology (German Cancer Research Center) Postdoctoral Scholar – Liver Disease (Pennsylvania State University) Postdoctoral Position – Liver Disease (University of Illinois) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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