Hepatic Cell News Volume 3.07 | Mar 1 2019

TOP STORY

Hepatic Sdf2l1 Controls Feeding-Induced ER Stress and Regulates Metabolism

Sdf2l1 was downregulated due to decreased levels of nuclear XBP-1s, whereas restoration of Sdf2l1 expression ameliorated glucose intolerance and fatty liver with decreased ER stress. In diabetic patients, insufficient induction of Sdf2l1 correlated with progression of insulin resistance and steatohepatitis. [Nat Commun] Full Article

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Dynamic Expression of ZNF382 and Its Tumor-Suppressor Role in Hepatitis B Virus-Related Hepatocellular Carcinogenesis

Functional studies demonstrated that zinc-finger protein 382 was a potent tumor suppressor in hepatocellular carcinoma cells through inhibiting cell proliferation, colony formation, migration, invasion, and tumorigenic potential in nude mice, and inducing cell apoptosis. [Oncogene] Abstract

Detection of DNA Damage Response in Nonalcoholic Fatty Liver Disease via p53-Binding Protein 1 Nuclear Expression

Researchers performed an in vitro assay using rat hepatocytes treated with the saturated free fatty acid palmitate. Treatment appeared to augment the number of abnormal foci, indicating an induction of double-strand breaks in the hepatocytes through free fatty acid treatment in a caspase-dependent manner. [Mod Pathol] Abstract

Glycine Decarboxylase Induces Autophagy and Is Downregulated by miRNA-30d-5p in Hepatocellular Carcinoma

Glycine decarboxylase (GLDC) overexpression significantly induced cell autophagy, whereas GLDC downregulation reduced cell autophagy. GLDC was the post-transcriptional target of miR-30d-5p. [Cell Death Dis] Full Article

PPARδ Attenuates Hepatic Steatosis through Autophagy-Mediated Fatty Acid Oxidation

Using genetic, pharmacological and metabolic approaches, scientists demonstrated that PPARδ reduced intrahepatic lipid content and stimulated β-oxidation in liver and hepatic cells by an autophagy-lysosomal pathway involving AMPK/mTOR signaling. [Cell Death Dis] Full Article

Somatic MIWI2 Hinders Direct Lineage Reprogramming from Fibroblast to Hepatocyte

Investigators uncovered a new somatic role for the PIWI proteins in mice that regulated cell plasticity in a trans-differentiation model of fibroblasts into hepatocyte-like cells. [Stem Cells] Full Article

Metformin and Glucose Starvation Decrease the Migratory Ability of Hepatocellular Carcinoma Cells: Targeting AMPK Activation to Control Migration

Migration/invasion was studied in hepatocellular carcinoma cells exposed to metformin and glucose starvation. Cell viability, proliferation and differentiation, as well as AMP activated kinase and PKA activation were analyzed. [Sci Rep] Full Article

Ameliorative Effect of Silybin on Bisphenol a Induced Oxidative Stress, Cell Proliferation and Steroid Hormones Oxidation in HepG2 Cell Cultures

Researchers investigated the effect of bisphenol A and silybin, alone or in combination, on proliferation, oxidative stress and steroid metabolism in HepG2 grown in high glucose concentration medium. Cell viability was assessed by adding 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide. [Sci Rep] Full Article

MicroRNA-449b-5p Targets HMGB1 to Attenuate Hepatocyte Injury in Liver Ischemia and Reperfusion

The authors found a protective effect of miR-449b-5p against hepatic ischemia/reperfusion injury. high mobility group box 1 expression significantly increased, whereas miR-449b-5p dramatically decreased in patients after liver transplant and in L02 cells exposed to hypoxia/reoxygenation. [J Cell Physiol] Abstract

The Proanthocyanidin-Rich Fraction Obtained from Red Rice Germ and Bran Extract Induces HepG2 Hepatocellular Carcinoma Cell Apoptosis

The proanthocyanidin-rich fraction (PRFR) obtained from red rice germ and bran extract could reduce the cell viability of HepG2 cells as shown by the IC50 value at 20 µg/mL. The results demonstrated that the PRFR obtained from red rice germ and bran extract could inhibit cell proliferation and induce cell apoptosis in HepG2 cells via survivin. [Molecules] Abstract | Graphical Abstract

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Connexin and Pannexin (Hemi)Channels: Emerging Targets in the Treatment of Liver Disease

The authors give an overview of the involvement of connexin-based and pannexin-based channels in noncancerous liver disease. [Hepatology] Abstract

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Stero Biotechs to Commence Phase II Clinical Trial of ST-AH-01 Cannabidiol Formulation for Ground Breaking Maintenance Therapy and Steroid Reduction in Patients with Autoimmune Hepatitis

Stero Biotechs has received Ethics Committee approval by Israel’s Ministry of Health and will soon enroll the first patients in a ground-breaking study to use CBD to reduce steroids in patients with liver disease. [STERO Biotechs Ltd (PR Newswire Association LLC)] Press Release

First Patient Dosed in a Clinical Trial of Tyvyt^® in Combination with IBI305 as First Line Treatment for Patients with Advanced Hepatocellular Carcinoma

Innovent Biologics, Inc. announced that the first patient has been dosed in ORIENT-32, a trial that evaluates Tyvyt^®, a fully human anti-programmed cell death protein 1 monoclonal antibody, in combination with IBI305, a recombinant humanized anti-vascular endothelial growth factor monoclonal antibody, as first-line treatment for patients with advanced hepatocellular carcinoma. [Innovent Biologics, Inc.] Press Release

NIH Letters Asking about Undisclosed Foreign Ties Rattle U.S. Universities

The National Institutes of Health (NIH) has recently sent letters to dozens of major U.S. research universities asking them to provide information about specific faculty members with NIH funding who are believed to have links to foreign governments that the Bethesda, Maryland–based institute did not know about. [ScienceInsider] Editorial

University of California Breaks Up With Major Publisher Over Research Access Dispute

After months of negotiations, the University of California system has decided not to renew its subscriptions to journals put out by the major publisher Elsevier — a decision that could have big ripple effects for the way that academic research gets read and paid for. [STAT News] Editorial

NEW The Liver Meeting
November 8-12, 2019
Boston, MA, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Non-Alcoholic Fatty Liver Disease (University of California, San Diego)

NEW Assistant Professor – Computational Biology/Stem Cell Biology (University of Illinois)

Postdoctoral Research Associate – Liver DIseases (University of Illinois at Chicago)

Senior Research Scientist – Nonalcoholic Steatohepatitis (Gilead Sciences, Inc)

Postdoctoral Position – Non-Alcoholic Fatty Liver Disease (London Foundation for Liver Research)

Postdoctoral Research Scientist – Cancer Biology (The Beatson Institute for Cancer Research)

Assistant/Associate Professor – Cancer Biology (Virginia Commonwealth University)

Postdoctoral Researcher – Cancer Biology (University of California, San Francisco)

Postdoctoral Researcher – Cancer Biology (University of Pennsylvania – Perelman School of Medicine)

Postdoctoral Positions – Development & Progression of Cancer (Rutgers Cancer Institute of New Jersey)

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