Hepatic Cell News Volume 3.21 | Jun 14 2019

TOP STORY

Hyaluronan Synthase 2-Mediated Hyaluronan Production Mediates Notch1 Activation and Liver Fibrosis

Hyaluronan (HA) production and liver fibrosis were reduced in mice lacking HA synthase 2 (HAS2) in hepatic stellate cells, whereas mice overexpressing HAS2 had exacerbated liver fibrosis. [Sci Transl Med] Abstract

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Depletion of TRRAP Induces p53‐Independent Senescence in Liver Cancer by Downregulating Mitotic Genes

The authors showed that depletion of transformation/transcription domain‐associated protein (TRRAP) or its co‐factor, histone acetyltransferase KAT5, inhibited hepatocellular carcinoma cell growth via induction of p53‐ and p21‐independent senescence. [Hepatology] Abstract

Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver

Researchers generated the most comprehensive genome-wide dataset of two epigenetic marks, H3K4me3 and H3K27ac, and annotated thousands of putative regulatory elements in the human liver. They integrated these findings with genome-wide gene expression data collected from the same human liver tissues and high-resolution promoter-focused chromatin interaction maps collected from human liver-derived HepG2 cells. [Am J Hum Genet] Full Article

Loss of LncRNA-SNHG7 Promotes the Suppression of Hepatic Stellate Cell Activation via miR-378a-3p and DVL2

Up-regulation of small nuclear RNA host gene 7 (SNHG7) was found in vivo and in vitro during liver fibrosis. Silencing of SNHG7 led to the suppression of hepatic stellate cell activation, with a reduction in cell proliferation and collagen expression. [Mol Ther Nucleic Acids] Full Article

YIPF2 Is a Novel Rab-GDF that Enhances HCC Malignant Phenotypes by Facilitating CD147 Endocytic Recycle

Current knowledge on CD147 trafficking to and from the cell-surface is limited. In this study, a membrane and secreted protein-cDNA library was screened against EpoR/LR-F3/CD147EP-expressed cells by mammalian protein–protein interaction trap. [Cell Death Dis] Full Article

Aquaporin 3 Maintains the Stemness of CD133⁺ Hepatocellular Carcinoma Cells by Activating STAT3

Investigators proved the carcinogenesis roles of aquaporin 3 (AQP3) in hepatocellular carcinoma and demonstrated that AQP3 promotes the stem cell-like properties of hepatoma cells by regulating CD133 expression. [Cell Death Dis] Full Article

miR-26a Promotes Hepatocellular Carcinoma Invasion and Metastasis by Inhibiting PTEN and Inhibits Cell Growth by Repressing EZH2

Gain-of-function and loss-of-function experiments demonstrated that miR-26a promoted migration and invasion of BEL-7402 and HepG2 cells in vitro and positively modulated matrix metalloproteinase (MMP)-1, MMP-2, MMP-9, and MMP-10 expression. [Lab Invest] Abstract

Overexpression of miRNA-25-3p Inhibits Notch1 Signaling and TGF-β-Induced Collagen Expression in Hepatic Stellate Cells

The authors examined the role of miR-25 in hepatic stellate cell (HSC) biology. miR-25 was detected in the human HSC cell line LX-2 and in primary murine HSCs, and increased with culture-induced activation. [Sci Rep] Full Article

Regulation of the Hepatitis B Virus Replication and Gene Expression by the Multi-Functional Protein TARDBP

Scientists identified TARDBP as a host factor that regulates hepatitis B virus (HBV). Silencing or knocking out the protein in HBV infected cells severely impaired the production of viral replicative intermediates, mRNAs, proteins, and virions, whereas ectopic expression of TARDBP rescued production of these products. [Sci Rep] Full Article

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ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis

The authors focus the attention on the role of extracellular signal-regulated kinase (ERK) signaling pathway as a critical one in modulating selected profibrogenic phenotypic responses operated by liver myofibroblasts. [Int J Mol Sci] Full Article

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New Data Released by Theratechnologies Demonstrate Positive Impact of Tesamorelin in Patients with Liver Fibrosis

Theratechnologies Inc. announced additional data from the recently completed study funded by the National Institutes of Health, led by Dr. Steve Grinspoon, and conducted at the Massachusetts General Hospital and Harvard Medical School and the National Institutes of Health. [Theratechnologies Inc.] Press Release

UCLA Professor’s Last Gift Will Support Research in Cancer and Stem Cell Biology

The gift established the Doumani Research Innovation Fund, which will support the work of faculty affiliated with the Broad Stem Cell Research Center and the UCLA Jonsson Comprehensive Cancer Center who are conducting multidisciplinary research aimed at translating scientific discoveries into new treatments for people with cancer. [University of California, Los Angeles] Press Release

Big Changes Needed to Fight Harassment, Group Tells US Biomedical Agency

The US National Institutes of Health (NIH) should make sweeping changes to how it funds research as part of its efforts to reduce sexual harassment in science, a working group advising the agency on the issue said on 13 June. The NIH should treat sexual misconduct as seriously as research misconduct, the group told agency director Francis Collins and his top advisers at a meeting in Bethesda, Maryland. [Nature News] Editorial

Wellcome Sanger Institute to Close Animal Facility

The Wellcome Sanger Institute announced that it would be closing its animal facility, which provides mice, zebrafish, rats, and frogs to geneticists at the institute and internationally, reports Nature. The institute states that the closure is related to the growing use of cell lines and organoids, instead of animals. [The Scientist] Editorial

NEW Advanced Cell Therapies and Tissue Engineering
November 14-16, 2019
Milan, Italy

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NEW Postdoctoral Position – Clinical Proteomics and Liver Metabolism (University of Copenhagen)

Postdoctoral Scientist – Epigenetic Mechanisms of NAFLD (Institute of Hepatology, Foundation for Liver Research)

Postdoctoral Position – Liver Disease (University of Illinois at Chicago)

Research Assistant – Liver Immunology (Maynooth University)

Postdoctoral Research Scientists – Hepatitis Virus Research (Ohio State University)

Faculty Position/Director – Cancer Research (Lewis Katz School of Medicine at Temple University)

Research Assistant – Liver Damage Research (University of Colorado Denver)

Tier I CIHR Canada Research Chair – Mechanisms of Health & Disease (Brock University)

Postdoctoral Fellow – Profiling Single Exosomes & Liver Metastasis Research (McGill University)

Research Scientist – Head of the Human Liver Cell Isolation Lab (University of California, San Diego)

Postdoctoral Researcher – Liver Mutagenesis (IRSET)

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