|
| Scientists aimed to identify key molecular signatures and related pathways leading to hepatocellular carcinoma resistance to trans‐arterial chemoembolization (TACE), with the hope of developing effective approaches in pre‐selecting patients with survival benefit from TACE. [Hepatology] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers found that suppression of EGFR signaling promoted liver progenitor cell‐to‐hepatocyte differentiation via the MEK‐ERK‐SOX9 cascade. [Hepatology] |
|
|
|
| Spheroids derived from doublecortin-like kinase 1 (DCLK1)-overexpressing hepatoma cells showed high level expression of active β-catenin, α-fetoprotein, and SOX9, suggesting that DCLK1 overexpression induced clonogenicity and dedifferentiated phenotypes in hepatoma cells. [Scientific Reports] |
|
|
|
| Researchers investigated whether hepatocyte-derived miR-200b-3p governed angiogenesis in hepatocellular carcinoma (HCC) by targeting endothelial erythroblast transformation-specific-related gene (ERG). [Scientific Reports] |
|
|
|
| While no major difference was observed after bile duct ligation or 3,5-diethoxycarbonyl-1,4-dihydrocollidine, platelet-derived growth factor receptor α loss in hepatic stellate cells (HSCs) led to a significant albeit transient reduction in fibrosis after CCl4 injury, associated with increased HSC death and reduced migration. [American Journal of Pathology] |
|
|
|
| The authors identified that the expression of the tumor-suppressive miRNA miR-375 was significantly induced in hepatoma cells treated with sorafenib, and miR-375 could exert its antiangiogenic effect partially via platelet-derived growth factor C inhibition. [Cancer Gene Therapy] |
|
|
|
| Investigators reproduced key non-alcoholic steatohepatitis (NASH) characteristics in vitro by exposing primary human hepatocytes, human skin stem cell-derived hepatic cells, HepaRG and HepG2 cell lines, as well as LX-2 cells to multiple factors that play a role in the onset of NASH. [Cell Biology and Toxicology] |
|
|
|
| Researchers evaluated the role of fibrillar collagens and basement membrane-associated matrix on actin cytoskeleton organization and the function of rat primary hepatocytes cultured on soft elastic polyacrylamide hydrogels. [Bioinspiration & Biomimetics] |
|
|
|
| Scientists investigated the effect of licorice roots extract on some metabolic pathways and their regulating miRNAs in hepatocellular carcinoma cells. [Nutrition and Cancer-An International Journal] |
|
|
|
|
| The authors conclude the current state of efforts to derive human induced pluripotent stem cells for potential use in the modeling and treatment of liver disease. [Cells Tissues Organs] |
|
|
|
|
| BeiGene, Ltd. announced that the Center for Drug Evaluation of the China National Medical Products Administration has accepted a supplemental new drug application of BeiGene’s anti-PD-1 antibody tislelizumab for the treatment of patients with previously treated unresectable hepatocellular carcinoma, the most common form of liver cancer. [BeiGene, Ltd. (GlobeNewswire, Inc.)] |
|
|
|
| DURECT Corporation announced it has initiated recruiting patients for its randomized, double-blind, placebo-controlled, multi-center Phase II study to evaluate the safety and efficacy of DUR-928 in hospitalized COVID-19 infected patients with acute liver or kidney injury. [DURECT Corporation] |
|
|
|
| Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year. [The Scientist] |
|
|
|
|
| August 17 – August 19 Virtual |
|
|
|
|
|
| Deep Genomics – Toronto, Ontario, Canada |
|
|
|
| University of Gothenburg – Gothenburg, Sweden |
|
|
|
| Columbia University Medical Center – New York, New York, United States |
|
|
|
| Beam Therapeutics – Cambridge, Massachusetts, United States |
|
|
|
| Yale University – New Haven, Connecticut, United States |
|
|
|
|