Hepatic Cell News Volume 4.31 | Aug 21 2020

May 12, 2022

HCN 4.31 | 2020-08-21

Hepatic Cell News by STEMCELL Technologies

Vol. 4.31 – 21 August, 2020

TOP STORY

Targeting Acid Ceramidase Inhibits YAP/TAZ Signaling to Reduce Fibrosis in Mice

Scientists showed that tricyclic antidepressants reduce hepatic fibrosis by inhibiting aCDase and increasing the bioactive sphingolipid ceramide. They demonstrated that targeting aCDase inhibited YAP/TAZ activity by potentiating its phosphorylation-mediated proteasomal degradation via the ubiquitin ligase adaptor protein β-TrCP.
[Science Translational Medicine]

Abstract

Learn more about HepatiCult Organoid Growth Medium (Mouse)

PUBLICATIONSRanked by the impact factor of the journal

Galectin-3
Favors Tumor Metastasis via the Activation of β-catenin Signaling in Hepatocellular Carcinoma

The Galectin-3-β-catenin-IGFBP3/vimentin signaling cascade was determined as a central mechanism controlling hepatocellular carcinoma metastasis, providing possible biomarkers for predicating vascular metastasis and sorafenib resistance.
[British Journal of Cancer]

Abstract

Computational
Repositioning of Dimethyl Fumarate for Treating Alcoholic Liver Disease

Investigators demonstrated that dimethyl fumarate significantly upregulated the nuclear factor erythroid 2-related factor 2 (NRF2) protein level, increased NRF2 phosphorylation, and promoted NRF2 nuclear localization in liver cells.
[Cell Death & Disease]

Full Article

Shedding
of Cancer Susceptibility Candidate 4 by the Convertases PC7/Furin Unravels a Novel Secretory Protein Implicated in Cancer Progression

Searching for new substrates of proprotein convertase 7, a quantitative proteomics screen for selective enrichment of N-glycosylated polypeptides secreted from hepatic HuH7 cells identified two human type-II transmembrane proteins of unknown function(s): Cancer Susceptibility Candidate 4 and Golgi Phosphoprotein.
[Cell Death & Disease]

Full Article

ATI-2173,
a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens

By selectively delivering the 5′-monophosphate to the liver, while retaining the unique anti-hepatitis B virus activity of the 5′-triphosphate, ATI-2173 may provide an improved pharmacokinetic profile for clinical use, reducing systemic exposure of clevudine and potentially eliminating skeletal myopathy.
[Antimicrobial Agents and Chemotherapy]

Full Article

Evaluation
of Cytotoxic T Lymphocyte-Mediated Anticancer Response against Tumor Interstitium-Simulating Physical Barriers

Using a microfluidic-based platform, researchers investigated the migration characteristics and performance of anticancer response of cytotoxic T lymphocyte targeting hepatic cancer cells via antigen-specific and allogeneic recognition.
[Scientific Reports]

Full Article

Real
Time Monitoring of Oxygen Uptake of Hepatocytes in a Microreactor Using Optical Microsensors

The authors investigated the cellular behaviour of three types of hepatocytes, HepG2 cells, HepG2-3A4 cells and primary mouse hepatocytes, towards their exposure to acetaminophen when the availability of oxygen for the cell is systematically varied.
[Scientific Reports]

Full Article

Integration
of Proteomics, Lipidomics, and Metabolomics Reveals Novel Metabolic Mechanisms Underlying N, N-Dimethylformamide Induced Hepatotoxicity

Scientists systematically integrated the quantitative proteomics, lipidomics, and metabolomics data obtained from the primary human hepatocytes exposed to N, N-Dimethylformamide, to depict the complicated biochemical reactions correlated to liver damage.
[Ecotoxicology and Environmental Safety]

Abstract Graphical Abstract

In this webinar on hepatic organoids review the biological characteristics and practical considerations of adding organoids to your research.

REVIEWS

Revealing
the Role of Peroxisome Proliferator-Activated Receptor β/δ in Nonalcoholic Fatty Liver Disease

The authors review the latest information on the effects of PPARβ/δ on nonalcoholic fatty liver disease, including its capacity to reduce lipogenesis, to alleviate inflammation and endoplasmic reticulum stress, to ameliorate insulin resistance, and to attenuate liver injury.
[Metabolism]

Abstract

INDUSTRY AND POLICY NEWS

Tiziana Granted a Patent on the Use of Milciclib in Combination with Tyrosine Kinase Inhibitors for Treatment of Hepatocellular Carcinoma and other Cancers

Tiziana Life Sciences has announced that the US Patent and Trademark Office has granted a patent on use of Milciclib in combination with tyrosine kinase inhibitors such as Sorafenib , Regorafenib and Lenvatinib for the treatment of hepatocellular carcinoma and other cancers in humans.
[Tiziana Life Sciences (GlobeNewswire, Inc.)]

Press Release

Grad
Students Challenge University-Mandated COVID-19 Agreements

On Saturday, Lauren Pope—a biology Ph.D. student at Stanford University—received an email detailing a “graduate student compact” she’ll be required to sign before she can register for the fall semester. The document lays out expectations for how students will behave on campus given fears of COVID-19 transmission, as well as punishment procedures for those who don’t follow the rules.
[Science]

Editorial

FEATURED EVENT

Targeting Acid Ceramidase Inhibits YAP/TAZ Signaling to Reduce Fibrosis in Mice

Galectin-3
Favors Tumor Metastasis via the Activation of β-catenin Signaling in Hepatocellular Carcinoma

Computational
Repositioning of Dimethyl Fumarate for Treating Alcoholic Liver Disease

Shedding
of Cancer Susceptibility Candidate 4 by the Convertases PC7/Furin Unravels a Novel Secretory Protein Implicated in Cancer Progression

ATI-2173,
a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens

Evaluation
of Cytotoxic T Lymphocyte-Mediated Anticancer Response against Tumor Interstitium-Simulating Physical Barriers

Real
Time Monitoring of Oxygen Uptake of Hepatocytes in a Microreactor Using Optical Microsensors

Integration
of Proteomics, Lipidomics, and Metabolomics Reveals Novel Metabolic Mechanisms Underlying N, N-Dimethylformamide Induced Hepatotoxicity

Revealing
the Role of Peroxisome Proliferator-Activated Receptor β/δ in Nonalcoholic Fatty Liver Disease

Tiziana Granted a Patent on the Use of Milciclib in Combination with Tyrosine Kinase Inhibitors for Treatment of Hepatocellular Carcinoma and other Cancers

Grad
Students Challenge University-Mandated COVID-19 Agreements

Channels
in Context: Structure and Function of Ion Channels in Macromolecular Complexes and Native Cells

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Postdoctoral Researcher – Immune Oncology

Research
Postdoctoral Fellow – Non-Alcoholic Fatty Liver Diseases & T2D

Staff
Scientist – Molecular Diagnostics & Experimental Therapeutics

Postdoctoral
Fellow – Diabetes and Cancer Metabolism

Postdoctoral Fellow – Pancreatic and Liver Malignancies

> See All Jobs