 | | Vol. 4.34 – 11 September, 2020 |
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| TREM-2 expression was analyzed in liver tissues of two independent cohorts of patients with hepatocellular carcinoma (HCC) and compared with control liver samples. Experimental HCC and liver regeneration models in wild type and Trem-2-/- mice, and in vitro studies with hepatic stellate cells and HCC spheroids were conducted.
[Gut] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators detected recurrent somatic p90 Ribosomal S6 kinase 2 (RSK2) mutations at a rate of 6.3% in hepatocellular carcinoma (HCC) cohorts, and revealed that HCC was the top-ranking cancer harboring RSK2 mutations among many cancer types.
[Journal of Hepatology] |
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| Scientists developed an hepatocellular carcinoma (HCC) extracellular vesicle (EV) purification system by synergistically integrating covalent chemistry-mediated EV capture/release, multimarker antibody cocktails, nanostructured substrates, and microfluidic chaotic mixers.
[Nature Communications] |
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| Hepatocytes overexpressing miR-192-3p exhibited improved lipid accumulation, accompanied with decreases in lipogenesis and lipid accumulation-related transcripts.
[JHEP Reports] |
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| Bromodomain-containing protein 9 (BRD9) expression was found to be elevated in hepatocellular carcinoma (HCC) through data mining of public databases. Scientists confirmed that the expression of BRD9 was increased in HCC tissues compared with that in adjacent non-tumor tissues. The upregulated level of BRD9 was also observed in HCC cells in comparison to LO2 cells.
[Cell Death & Disease] |
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| In primary mouse hepatocytes, A-485 abolished cAMP-elicited mRNA expressions of key gluconeogenic enzymes and promoted FOXO1 protein degradation via increasing its ubiquitination.
[Cell Death & Disease] |
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| Researchers elucidated the anti-fibrotic effects of neratinib in hepatic stellate cells (HSCs) and in vivo models of CCl4-induced liver fibrosis. HSC activation was a key step in liver fibrogenesis and played a crucial role in collagen deposition, as it is primarily responsible for excessive ECM production.
[Scientific Reports] |
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| Using nuclear PTEN-deficient mice, scientists analyzed the role of PTEN in the nucleus in hepatocellular carcinoma that was induced by carcinogen and oxidative-stress producing hepatotoxin.
[iScience] |
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| Researchers examined the roles of group 2 innate lymphoid cells (ILC2s) in amebic liver abscesses formation. Hepatic ILC2 numbers were significantly increased and they produced robust levels of IL-5.
[iScience] |
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| Diseases like non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) bring a very high level of pathogenic complexity and far-reaching implications that apply not only scientists but also to clinicians, patients, regulators, bio-pharmaceutical industry and third-party payers.
[Journal of Hepatology] |
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| Investigators summarize current understanding of the function of lncRNAs in the liver in both health and disease and discuss approaches that could be used to target these noncoding transcripts for therapeutic purposes.
[JHEP Reports] |
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| The authors aimed to evaluate the effect of bisphosphonates on overall cancers. They note that non-nitrogen-containing bisphosphonates might increase the risk of liver and pancreas cancer. Large prospective cohort studies are needed to find the causal association between bisphosphonates and risk of cancers.
[British Journal of Cancer] |
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| Theratechnologies Inc. has announced that it plans to pursue Phase III clinical development of tesamorelin for the treatment of non-alcoholic steatohepatitis (NASH) in the general population.
[Theratechnologies Inc. (GloveNewswire Inc.)] |
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| | Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine – Guangzhou, China or Maine, United States |
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| | Temple University Medical School – Philadelphia, Pennsylvania, United States |
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| | Texas Biomedical Research Institute – San Antonio, Texas, United States |
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| | Institute for Virology, University Hospital Cologne – Cologne, Germany |
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| | Texas Biomedical Research Institute – San Antonio, Texas, United States |
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