 | | Vol. 4.38 – 16 October, 2020 |
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| Scientists experimentally demonstrated the responsiveness of selected hepatic long non-coding (lnc)RNAs to defined metabolic milieus in a liver-specific humanized mouse model. By extracting a concise list of protein-coding genes that were persistently correlated with lncRNAs in general and nonalcoholic fatty liver disease populations, they predicted the specific function for each human lncRNA metabolic regulator.
[Journal of Clinical Investigation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors investigated the early transcriptional events of cellular reprogramming triggered by the co‐expression of Oct4, Sox2, Klf4, and c‐Myc in mouse embryonic fibroblasts and mouse hepatocytes.
[EMBO Journal] |
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| Investigators analyzed the levels of mRNA transcripts in serum‐starved primary WT and KO mouse hepatocytes using RNA sequencing data, and found that cyclic AMP response element‐binding protein target genes were downregulated.
[EMBO Journal] |
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| IFN-I specifically rewired tryptophan metabolism and induced hepatic tryptophan oxidation to kynurenine via Tdo2, correlating with altered concentrations of serum metabolites upon viral infection.
[PLoS Pathogens] |
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| The well-organized, simplistic, and biological route of silver nanoparticles (AgNPs) was synthesized using shrimp shell extracted chitin as reducing, capping and stabilizing factor under the optimized conditions. The anticancer potential of synthesized biogenic AgNPs was evaluated against human hepatocarcinoma cells.
[International Journal of Biological Macromolecules] |
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| c‐Myc regulated hnRNPU expression at the transcriptional level, and meanwhile hnRNPU stabilized the mRNA of c‐MYC. Investigators found that the hnRNPU and c‐Myc regulatory loop exerted a synergistic effect on the proliferation and self‐renewal of hepatocellular carcinoma (HCC), and promoted HCC progression.
[FEBS Letters] |
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| Scientists describe the latest findings in thyroid hormone research in the field of aging, diabetes, and cancer, with a special focus on hepatocellular carcinomas.
[Aging Cell] |
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| The authors give a comprehensive catalogue of well reported lncRNAs in non-alcoholic fatty liver disease and classify them using sequence and synteny-based evolutionary conservation across rodents, nonhuman primate and human species.
[Life Sciences] |
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| Mirum Pharmaceuticals, Inc. announced it has partnered with EVERSANA™ to lead the US market access, distribution and patient services for maralixibat, a novel, minimally absorbed, orally administered investigational drug being evaluated in several rare cholestatic liver diseases.
[Mirum Pharmaceuticals, Inc.] |
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| Inventiva announced that the FDA has granted Breakthrough Therapy designation to lanifibranor, the company’s lead drug candidate, for the treatment of non-alcoholic steatohepatitis (NASH).
[Inventiva] |
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| The Royal Society of Edinburgh, Scotland’s National Academy, has announced the winners of its highly prestigious medals, which recognize exceptional achievement in science, academia and public engagement.
[The Royal Society of Edinburgh] |
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| March 17 – March 19
Virtual |
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| | Karolinska Institutet – Huddinge, Sweden |
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| | Medical University of Vienna – Vienna, Austria |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | University of Toronto – Toronto, Ontario, Canada |
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| | University of Miami – Miami, Florida, United States |
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