Hepatic Cell News Volume 4.40 | Oct 23 2020

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    2020-10-23 | HCN 4.39


    Hepatic Cell News by STEMCELL Technologies
    Vol. 4.39 – 23 October, 2020
    TOP STORY

    Direct
    Reprogramming of Human Umbilical Vein- and Peripheral Blood-Derived Endothelial Cells into Hepatic Progenitor Cells

    Scientists showed that a set of three transcription factors, FOXA3, HNF1A, and HNF6, could induce human umbilical vein endothelial cells to directly acquire the properties of human hepatic progenitor cells.
    [Nature Communications]

    Full Article

    In this webinar on hepatic organoids review the biological characteristics and practical considerations of adding organoids to your research.
    PUBLICATIONSRanked by the impact factor of the journal

    YAP
    Orchestrates Heterotypic Endothelial Cell Communication via HGF/C-MET Signaling in Liver Tumorigenesis

    In yes-associated protein (YAP)S127A-induced tumorigenesis, a gradual replacement of liver sinusoidal endothelial cells by continuous endothelial cells was associated with dynamic changes in the expression of genes involved in paracrine communication.
    [Cancer Research]

    Abstract

    BCL11B
    Suppresses Tumor Progression and Stem Cell Traits in Hepatocellular Carcinoma by Restoring p53 Signaling Activity

    In vitro and in vivo experiments confirmed BCL11B as a tumor suppressor in hepatocellular carcinoma with inhibitory effects on proliferation, cell cycle progression, apoptosis, and mobility.
    [Cell Death & Disease]

    Full Article

    The
    miR-30a-5p/CLCF1 Axis Regulates Sorafenib Resistance and Aerobic Glycolysis in Hepatocellular Carcinoma

    The aberrant glucose metabolism in cancer cells aerobic glycolysis is associated with resistance to chemotherapeutic agents. Drug-resistance cells and tumors were exposed to sorafenib to establish sorafenib-resistance cell lines and tumors.
    [Cell Death & Disease]

    Full Article

    PDSS2-Del2,
    a New Variant of PDSS2, Promotes Tumor Cell Metastasis and Angiogenesis in Hepatocellular Carcinoma via Activating NF-κB

    Prenyl diphosphate synthase subunit 2 in hepatocellular carcinoma (HCC) with deletion of exon 2 (PDSS2‐Del2) levels correlated significantly with microvessel counts in HCCtumor tissues. Importantly, PDSS2‐Del2 overexpression functionally promoted HCC metastasis as demonstrated by in vitro and in vivo migration assays.
    [Molecular Oncology]

    AbstractFull Article

    Preparation,
    Characterization and Therapeutic Properties of Gum Arabic-Stabilized Gallic Acid Nanoparticles

    Gallic acid nanoparticles were evaluated for the in vitro cytotoxicity, cell uptake and cell migration in four types of human cancer cell lines including breast adenocarcinoma, HepG2 hepatocellular cancer, HT-29 colorectal adenocarcinoma, and MCF-10A breast epithelial cell lines.
    [Scientific Reports]

    Full Article

    Generation
    of Human Induced Pluripotent Stem Cell-Derived Liver Buds with Chemically Defined and Animal Origin-Free Media

    Scientists developed a defined, animal origin-free (CD-AOF) medium to generate all induced pluripotent stem cell-liver buds. Scientists developed a CD-AOF medium for hepatocytes, endothelial cells, and stage-matched mesenchymal stem cells i.e., septum transversum mesenchyme, in 2D cultures.
    [Scientific Reports]

    Full Article

    Survey Report: Where Is Pluripotent Stem Cell Research Now?
    REVIEWS

    Nonalcoholic
    Steatohepatitis: The Role of Peroxisome Proliferator-Activated Receptors

    The authors summarize and discuss the current literature on nonalcoholic fatty liver disease as the liver manifestation of the systemic metabolic syndrome and focuses on the role of peroxisome proliferator-activated receptors in the pathomechanisms as well as in the potential targeting of disease.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    INDUSTRY AND POLICY NEWS

    The Unsung Heroes of the Nobel-Winning Hepatitis C Discovery

    A tight-knit team of scientists worked feverishly to identify the deadly virus. Only one of them was awarded the Nobel.
    [Nature News]

    Editorial


    Georgia State Start-Up Awarded NIH Grant To Develop Contrast Agent for Early Detection of Liver Disease

    Inlighta Biosciences, LLC, a start-up company led by Jenny Yang, Regents’ Professor of Chemistry at Georgia State University, has been awarded a National Institute of Health grant to accelerate development of a magnetic resonance imaging contrast agent to detect liver fibrosis, formation of scar tissue in the liver caused by alcoholic and non-alcoholic fatty liver disease.
    [Georgia State University]

    Press Release
    FEATURED EVENT

    Keystone
    Symposia: Hepatobiliary Cancers: Pathobiology and Translational Advances

    March 22 – March 24, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Statistical
    Geneticist – Disorders of the Liver, Eye and Nervous System

    Deep Genomics, Inc. – Toronto, Ontario, Canada

    Postdoctoral Positions – Stem Cells, Immunology, Biochemistry/Molecular Biology, Pathogenic Microbiology

    Zhejiang University-University of Edinburgh Institute – Haining, Zhejiang, China

    Postdoctoral Positions – Translational Oncology

    Medical University of Vienna – Vienna, Austria

    Faculty Position – Cancer Biology

    University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral
    Position – Bioinformatics (Epigenomics)

    University of Toronto – Toronto, Ontario, Canada

    > See All Jobs

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