 | | Vol. 4.42 – 13 November, 2020 |
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| To investigate whether CYP1A2 and NF‐κB p65 played roles in sorafenib desensitization, the authors established sorafenib-resistant (SR) hepatocellular carcinoma cells. SR cells decreased the expression of CYP1A2 along with the upregulation of NF‐κB p65.
[Oncogene] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists observed that cluster differentiation 44 standard isoform (CD44s) was responsible for caspase-1/IL1B activation both in hepatocellular carcinoma (HCC) tissues and five HCC cell lines. In normoxia conditions, CD44s knockdown repressed the activation of caspase-1/IL1B via stimulating AMPK-mediated autophagy.
[Cell Death & Disease] |
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| Investigators found that translationally controlled tumor protein (TCTP) protein was overexpressed in hepatocellular carcinoma patients but TCTP mRNA expression levels were reversed.
[Cell Death & Disease] |
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| Researchers showed by genetic lineage tracing that PROM1+ cells were derived in part from hepatocytes in alcoholic hepatitis and became tumor cells in mice with diethyl nitrosamine-initiated, Western alcohol diet-promoted liver tumorigenesis.
[Scientific Reports] |
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| Scientists found definite lipidomic and transcriptomic changes in the hepatocellular carcinoma lines upon knockdown of macroH2A1 or focal adhesion kinase, in line with the acquisition or loss of stemness features.
[International Journal of Molecular Sciences] |
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| Investigators demonstrated the immune response mediated by an adeno-associated viruse (AAV) vector in a mouse model. Mice were infected intravenously with 4×10ˆ12 cp/kg of AAV8 and the ensuing immune response was analyzed using intravital microscopy, over a period of weeks.
[Molecular Therapy-Methods & Clinical Development] |
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| Cell cytotoxicity was measured by clonogenic survival or relative cell growth and the DNA damage response using immunological-based techniques in Hep3B, PLC/PRF/5, HepG2- and HepaRG-derived models.
[Clinics and Research in Hepatology and Gastroenterology] |
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| The authors highlight the implications of sexual dimorphism in the pathophysiology of obesity-related cardiometabolic risk for the development of sex-specific prevention and treatment strategies.
[Nature Reviews Endocrinology] |
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| Intellia
Therapeutics, Inc.announced that the first patient has been treated with NTLA-2001, which the company is developing as a single-course, potentially curative therapy for transthyretin amyloidosis (ATTR). Intellia’s global Phase I study is to evaluate NTLA-2001 for hereditary ATTR with polyneuropathy.
[Intellia Therapeutics, Inc.] |
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| Distinguished Awards acknowledge individuals and organizations for their exemplary and sustained service to the AASLD, the field of liver disease, and the liver community in general.
[American Association for the Study of Liver Diseases] |
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| April 11 – April 13, 2021
San Diego, California, United States |
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| | Stanford University – Stanford, California, United States |
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| | Deep Genomics, Inc. – Toronto, Ontario, Canada |
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| | Zhejiang University-University of Edinburgh Institute – Haining, China |
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| | Medical University of Vienna – Vienna, Austria |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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