Hepatic Cell News Volume 4.47 | Dec 11 2020

May 12, 2022

2020-12-11 | HCN 4.27

Hepatic Cell News by STEMCELL Technologies

Vol. 4.27 – 11 December, 2020

TOP STORY

Loss
of Hepatic Aldolase B Activates Akt and Promotes Hepatocellular Carcinogenesis by Destabilizing the Aldob/Akt/PP2A Protein Complex

Scientists demonstrated that Aldob suppressed Akt activity and tumor growth through a protein complex containing Aldob, Akt, and protein phosphatase 2A (PP2A), leading to inhibition of cell viability, cell cycle progression, glucose uptake, and metabolism.
[PLoS Biology]

Full Article

Request a free copy of the Growing Organoids from Stem Cells Wallchart

PUBLICATIONSRanked by the impact factor of the journal

Gene
Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids

The authors demonstrated that integrated analysis and engineering of gene regulatory networks in PSC-derived multilineage human liver organoids directed maturation and vascular morphogenesis in vitro.
[Cell Systems]

Full Article Graphical Abstract

Functional
Crosstalk between Myeloid Foxo1-β-Catenin Axis and Hedgehog/Gli1 Signaling in Oxidative Stress Response

Researchers report that myeloid-specific Foxo1 knockout (Foxo1M-KO) mice were resistant to oxidative stress-induced hepatocellular damage with reduced macrophage/neutrophil infiltration, and pro-inflammatory mediators in liver ischemia/reperfusion injury.
[Cell Death & Differentiation]

Full Article

HDAC8-Dependent
Deacetylation of PKM2 Directs Nuclear Localization and Glycolysis to Promote Proliferation in Hepatocellular Carcinoma

Investigators found that K62 residues were deacetylated, which was related to the prognosis of hepatocellular carcinoma. Further studies indicated that HDAC8 bound and deacetylated the K62 residue of PKM2.
[Cell Death & Disease]

Full Article

Stress
Can Attenuate Hepatic Lipid Accumulation via Elevation of Hepatic β-Muricholic Acid Levels in Mice with Nonalcoholic Steatohepatitis

βMCA suppressed lipid accumulation in mouse primary hepatocytes exposed to palmitic acid/oleic acid, but cholic acid did not. In addition, Cyp7a1 expression seemed to be related to lipid accumulation in hepatocytes.
[Laboratory Investigation]

Abstract

Loss
of miR-100 and miR-125b Results in Cancer Stem Cell Properties through IGF2 Upregulation in Hepatocellular Carcinoma

Overexpression of stemness factors NANOG, OCT4 and SOX2 by introduction of gene constructs in Hep3B cells suppressed two miRNA expression levels. Treatment of chromeceptin, an IGF signaling pathway inhibitor, decreased numbers of tumorsphere and inhibited the AKT/mTOR pathway.
[Scientific Reports]

Full Article

RNA
Sequencing Reveals Changes in the MicroRNAome of Transdifferentiating Hepatic Stellate Cells That Are Conserved between Human and Rat

Researchers employed next generation sequencing to map alterations in the expression of microRNAs occurring across a detailed time course of culture-induced transdifferentiation of primary human hepatic stellate cells, a key event in fibrogenesis.
[Scientific Reports]

Abstract

FN-EDA
Mediates Angiogenesis of Hepatic Fibrosis via Integrin-VEGFR2 in a CD63 Synergetic Manner

Fibronectin containing extra domain A (FN-EDA) was positively correlated with pathological angiogenesis in hepatic fibrosis, and a reduction in FN-EDA expression was associated with diminished intrahepatic angiogenesis and fibrosis.
[Cell Death Discovery]

Full Article

Virtual Conference Exhibition: Pluripotent Stem Cells

REVIEWS

Hepatocellular Carcinoma: Old Friends and New Tricks

The authors discuss the suite of hepatcellular carcinoma (HCC)-associated genetic changes and describe recent studies that provide evidence for an evolving functional model and its implications for understanding and targeting HCC progression.
[Experimental and Molecular Medicine]

Full Article

INDUSTRY AND POLICY NEWS

Arbutus
Announces Robust HBsAg Decline Data with AB-729 Dosed at 60 mg Every 8 Weeks in Chronic Hepatitis B Subjects

Arbutus Biopharma Corporation announced additional clinical data from an ongoing Phase Ia/Ib clinical trial with AB-729, its proprietary GalNAc delivered RNAi compound.
[Arbutus Biopharma Corporation]

Press Release

Altimmune
Commences Dosing in Phase I Clinical Trial of ALT-801, a Long-Acting GLP-1/Glucagon Receptor Dual Agonist for the Treatment of NASH

Altimmune, Inc. announced that it has commenced dosing in a Phase I single ascending dose and multiple ascending dose clinical study of ALT-801. ALT-801 is a long-acting GLP-1/glucagon receptor dual agonist being developed for the treatment of non-alcoholic steatohepatitis (NASH), which is expected to affect more than 13 million adults in the United States.
[Altimmune, Inc.]

Press Release

FEATURED EVENT

Loss
of Hepatic Aldolase B Activates Akt and Promotes Hepatocellular Carcinogenesis by Destabilizing the Aldob/Akt/PP2A Protein Complex

Gene
Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids

Functional
Crosstalk between Myeloid Foxo1-β-Catenin Axis and Hedgehog/Gli1 Signaling in Oxidative Stress Response

HDAC8-Dependent
Deacetylation of PKM2 Directs Nuclear Localization and Glycolysis to Promote Proliferation in Hepatocellular Carcinoma

Stress
Can Attenuate Hepatic Lipid Accumulation via Elevation of Hepatic β-Muricholic Acid Levels in Mice with Nonalcoholic Steatohepatitis

Loss
of miR-100 and miR-125b Results in Cancer Stem Cell Properties through IGF2 Upregulation in Hepatocellular Carcinoma

RNA
Sequencing Reveals Changes in the MicroRNAome of Transdifferentiating Hepatic Stellate Cells That Are Conserved between Human and Rat

FN-EDA
Mediates Angiogenesis of Hepatic Fibrosis via Integrin-VEGFR2 in a CD63 Synergetic Manner

Hepatocellular Carcinoma: Old Friends and New Tricks

Arbutus
Announces Robust HBsAg Decline Data with AB-729 Dosed at 60 mg Every 8 Weeks in Chronic Hepatitis B Subjects

Altimmune
Commences Dosing in Phase I Clinical Trial of ALT-801, a Long-Acting GLP-1/Glucagon Receptor Dual Agonist for the Treatment of NASH

Eradicate Cancer

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Postdoctoral Fellow – Host/Microbiome Interactions in Liver Disease

Associate
Professor – Cancer Biology

Senior
Investigator – Replication Stress and Chromatin Alterations

Postdoctoral Studies – Cardiometabolic Research and NAFLD

Research Professional – Life Sciences

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