Hepatic Cell News Volume 5.01 | Jan 15 2020

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    Justin.choi
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    2020-12-15 | CBN 5.01


    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.01 – 15 January, 2021
    TOP STORY

    Chemotherapy-Enriched
    THBS2-Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications

    The local soft spots created by liver cancer stem cells could enhance stemness and drug resistance and provide a route of escape to facilitate hepatocellular carcinoma metastasis.
    [Advanced Science]

    Full Article

    In this webinar on hepatic organoids review the biological characteristics and practical considerations of adding organoids to your research.
    PUBLICATIONSRanked by the impact factor of the journal

    Engineering Human Hepato-Biliary-Pancreatic Organoids from Pluripotent Stem Cells

    Investigators describe a protocol for the continuous patterning of hepatic, biliary and pancreatic structures from a 3D culture of human pluripotent stem cells.
    [Nature Protocols]

    Abstract

    Histone
    Deacetylase 2 Regulates ULK1 Mediated Pyroptosis during Acute Liver Failure by the K68 Acetylation Site

    Researchers investigated whether knockdown or pharmacological inhibition of histone deacetylase 2 could reduce the level of pyroptosis in acute liver failure through ULK1-NLRP3-pyroptosis pathway.
    [Cell Death & Disease]

    Full Article

    Induced
    Hepatic Stellate Cell Integrin, α8β1, Enhances Cellular Contractility and TGFβ Activity in Liver Fibrosis

    Integrin α‐subunits were investigated systematically for their expression over the course of hepatic stellate cells activation and their distribution on fibroblasts and other systemic primary cells.
    [Journal of Pathology]

    Abstract

    CircRNA
    GFRA1 Promotes Hepatocellular Carcinoma Progression by Modulating the miR-498/NAP1L3 Axis

    Scientists carried out a list of characterization experiments to investigate the roles and underling mechanisms of circGFRA1 and miR-498 in hepatocellular carcinoma progressions.
    [Scientific Reports]

    Full Article

    Generation
    of Proliferating Human Adult Hepatocytes Using Optimized 3D Culture Conditions

    The authors describe optimized 3D culture conditions of primary human hepatocytes to trigger two waves of proliferation and identified matrix stiffness and cell–cell interactions as the main actors necessary for this proliferation.
    [Scientific Reports]

    Full Article

    Prediction
    and Verification of Target of Helenalin against Hepatic Stellate Cell Activation Based on miR-200a-Mediated PI3K/Akt and NF-κB Pathways

    Hepatic stellate cell (HSC)‐T6 cells were activated by interleukin-1 beta and then treated with helenalin. HSC‐T6 cells were transfected with miR-200a mimic or inhibitor, and the effect of helenalin on the miR-200a-mediated PI3K/Akt and NF-κB signaling pathways was investigated.
    [International Immunopharmacology]

    Abstract

    Cholangiogenic
    Potential of Human Deciduous Pulp Stem Cell-Converted Hepatocyte-Like Cells

    Stem cells from human exfoliated deciduous teeth-derived hepatocytes were intrasplenically transplanted into chronically CCl4-treated liver fibrosis model mice, followed by the analysis of donor integration and hepatobiliary metabolism in vivo.
    [Current Stem Cell Research & Therapy]

    Full Article

    MicroRNA-494-3p
    Prevents Liver Fibrosis and Attenuates Hepatic Stellate Cell Activation by Inhibiting Proliferation and Inducing Apoptosis through Targeting TRAF3

    Alcoholic hepatitis mice model and primarily cultured mice hepatic stellate cells model were constructed. Levels of aspartate aminotransferase and alanine aminotransferase were analyzed by ELISA.
    [Annals of Hepatology]

    Full Article
    Explore scientific events this January with the Science Events Calendar.
    REVIEWS

    Advances in Liver Cancer Stem Cell Isolation and Their Characterization

    Investigators review the research progress made in the isolation and characterization of liver cancer stem cells by considering a wide range of cell surface markers and sorting methods, as applied to side populations, microsphere cultures and the gradient centrifugation method.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Gilead and Vir Biotechnology Establish Clinical Collaboration to Explore Combination Strategies for Functional Cure for Chronic Hepatitis B Virus

    Gilead Sciences, Inc. and Vir Biotechnology, Inc. announced that the companies have entered into a clinical collaboration to evaluate novel therapeutic combination strategies aimed at developing a functional cure for chronic hepatitis B virus.
    [Gilead Sciences, Inc. (BusinessWire, Inc)]

    Press Release
    FEATURED EVENT

    ISSCR: Stem Cells and Global Sustainability

    February 3 – 23, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

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    Analysis Specialist – Cancer and Chronic Diseases

    Novo Nordisk – Copenhagen, Denmark

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    STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada

    Associate
    Professor – Cancer Biology

    University of Cincinnati – Cincinnati, Ohio, United States

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    Investigator – Replication Stress and Chromatin Alterations

    NIH National Cancer Institute – Bethesda, Maryland, United States

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    Stanford University – Stanford, California, United States

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