 | | Vol. 5.06 – 19 February, 2021 |
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| In cultured hepatic stellate cells, extracellular 6His‐tagged recombinant human cytoglobin was endocytosed and accumulated in endosomes via clathrin‐mediated pathway.
[Hepatology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers evaluated the effects of cordycepin on lipid storage in hepatocytes, inflammation, and fibrosis development in mice with nonalcoholic steatohepatitis.
[Hepatology] |
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| Scientists report that HDAC11 was highly expressed in hepatocellular carcinoma and was closely related to disease prognosis. Depletion of HDAC11 in a conditional knockout mouse model reduced hepatocellular tumorigenesis and prolonged survival.
[Cancer Research] |
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| Researchers showed that in hepatocellular carcinoma tumors the highest expression level of HK2 was inversely correlated to GCK expression, and was associated to poor prognosis for patient survival.
[Communications Biology] |
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| The effects of lactonic sophorolipids and cell death inhibitors were measured by MTT test on HepG2 cells. Their morphology of the cells was observed under a microscope.
[Applied Microbiology and Biotechnology] |
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| To mimic liver fibrosis in vitro, LX-2 cells were treated with TGF-β. Gene and protein expressions were detected by RT-qPCR and western blot, respectively.
[Human Cell] |
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| The recovery of C2orf40 expression in hepatocellular carcinoma cell lines could induce G0/G1 phase arrest and apoptosis, and also inhibit cell migration and invasion by reversing the epithelial–mesenchymal transition process, both in vivo and in vitro.
[Journal of Gastroenterology and Hepatology] |
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| The authors summarize findings indicating that the dysregulation of stress kinases plays a fundamental role in the development of steatosis and are important players inducing liver fibrosis.
[Molecular Metabolism] |
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| Investigators discuss the role of platelets in liver fibrosis and accompanying hemostatic disorders. They present the results of animal and human studies on antiplatelet drugs in liver disorders and their potential therapeutic utility.
[Platelets] |
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| Associate Professor of Medicinal Chemistry at Ferris State University, Dr. Sonali Kurup has learned the National Institutes of Health approved her proposal for $377,805 to fund an investigation into novel dual-targeted inhibitors of EGFR and aurora kinase. These enzymes contribute to uncontrolled cancer cell division and resistance to approved anticancer agents.
[Ferris State University] |
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| September 5 – 8, 2021
Exeter, England, United Kingdom |
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| | Gilead Sciences, Inc. – Foster City, California, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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