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| Scientists found that circMEMO1 was significantly downregulated in hepatocellular carcinoma (HCC) samples and that the level of circMEMO1 was closely related to the OS and disease-free survival of HCC patients.
[Molecular Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported the discovery of DI-1548 and DI-1859 as two potent, selective and covalent DCN1 inhibitors. These inhibitors selectively inhibited neddylation of cullin 3 in cells at low nanomolar concentrations and were two-three orders of magnitude more potent than previously reported reversible DCN1 inhibitor.
[Nature Communications] |
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| Researchers investigated the Fas/FasL signaling and hepatocytes apoptosis in liver samples from both human sections and mouse models.
[Cell Death & Disease] |
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| Mechanism studies revealed that bufalin directly bonded to SDC4 and selectively increased SDC4 interaction with substrate protein DEAD-box helicase 23 to induce hepatocellular carcinoma genomic instability.
[Cell Death & Disease] |
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| Investigators found that blueberry-derived exosomes-like nanoparticles could ameliorate oxidative stress in rotenone-induced HepG2 cells and high-fat diet-fed C57BL/6 mice.
[Acta Pharmacologica Sinica] |
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| Researchers showed that fragile X mental retardation protein modulated the localization and translation of STAT3 mRNA, accelerating hepatocellular carcinoma metastasis.
[Communications Biology] |
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| Scientists hypothesized an interplay between hepatic apolipoprotein J, cholesterol esterification and lipid deposit in response to non-alcoholic fatty liver disease inducers.
[Communications Biology] |
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| Cryopreserved hepatocytes from humans, rats, and rainbow trout were used to measure CLint values for 54 industrial and pesticidal chemicals at starting test concentrations of 0.1 and 1 µM.
[Toxicology] |
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| Researchers found that mitochondrial transcription factor B2 (TFBM2) promoted the progression of hepatocellular carcinoma cells through HIF‐1α‐regulated reprogramming of glucose metabolism.
[Journal of Gastroenterology and Hepatology] |
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| Scientists investigated the effects of the PI3K inhibitor LY‑294002 and AKT inhibitor MK2206 on the chemosensitivity of oxaliplatin‑resistant liver cancer cells and the molecular mechanism involved.
[Molecular Medicine Reports] |
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| Investigators provide an in-depth discussion of the underlying pathogenetic mechanisms that lead to progressive liver injury, including the metabolic origins of nonalcoholic fatty liver disease (NAFLD), the effect of NAFLD on hepatic glucose and lipid metabolism, bile acid toxicity, macrophage dysfunction, and hepatic stellate cell activation, and consider the role of genetic, epigenetic, and environmental factors that promote fibrosis progression and risk of hepatocellular carcinoma in nonalcoholic steatohepatitis.
[Cell] |
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| Scientists provide an overview of chemokine biology, with a particular focus on the genetic and epigenetic regulation of chemokine transcription as well as on the cell type-specific production of chemokines by liver cells and liver-associated immune cells.
[Nature Reviews Gastroenterology & Hepatology] |
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| Axcella, Inc. announced that it has activated initial clinical sites and begun patient screening for its EMMPACT Phase IIb clinical trial of AXA1125, the company’s multi-targeted oral product candidate for the treatment of NASH.
[Axcella, Inc (Business Wire, Inc.)] |
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| January 12 – 14, 2022
Shanghai, China |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | The Griffin Institute – Harrow, United Kingdom |
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| | University of Wisconsin-Madison – Madison, Wisconsin, United States |
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| | Deep Genomics, Inc. – Toronto, Ontario, Canada |
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