Hepatic Cell News Volume 5.18 | May 21 2021

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    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.18 – 21 May, 2021
    TOP STORY

    AXCR1+ Type 1 Conventional Dendritic Cells Drive Liver Pathology in Non-Alcoholic Steatohepatitis

    Researchers identified a significant pathology-associated increase in hepatic conventional dendritic cells (cDC) and further defined their source as non-alcoholic fatty liver disease-induced boost in cycling of cDC progenitors in the bone marrow.
    [Nature Medicine]

    Full Article

    Guide to everything you need to know about cell separation.
    PUBLICATIONSRanked by the impact factor of the journal

    PKM2-Dependent Metabolic Skewing of Hepatic Th17 Cells Regulates Pathogenesis of Non-Alcoholic Fatty Liver Disease

    Scientists uncovered and characterized a distinct population of inflammatory hepatic CXCR3+Th17 cells sufficient to exacerbate non-alcoholic fatty liver disease pathogenesis.
    [Cell Metabolism]

    AbstractGraphical Abstract

    UBQLN1 Mediates Sorafenib Resistance through Regulating Mitochondrial Biogenesis and ROS Homeostasis by Targeting PGC1β in Hepatocellular Carcinoma

    The authors investigated the roles of ROS in sorafenib resistance, and found suppressed ROS levels and reductive redox states in sorafenib-resistant hepatocellular carcinoma cells.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Inhibiting xCT/SLC7A11 Induces Ferroptosis of Myofibroblastic Hepatic Stellate Cells but Exacerbates Chronic Liver Injury

    Investigators evaluated the hypothesis that myofibroblastic (activated) hepatic stellate cells and liver fibrosis could be safely reduced by inhibiting the cysteine/glutamate antiporter xCT.
    [Liver International]

    Full Article

    SRSF1 Promotes the Inclusion of Exon 3 of SRA1 and the Invasion of Hepatocellular Carcinoma Cells by Interacting with Exon 3 of SRA1pre-mRNA

    Researchers found up regulated expression of SRSF1 and steroid receptor RNA activator 1 (SRA1)-L in highly metastatic HCCLM3, as well as in hepatocellular carcinomas with SRSF1 demonstrating the strongest correlation with SRA1-L.
    [Cell Death Discovery]

    Full Article

    Dimethyl Fumarate Reduces Hepatocyte Injury Following Paracetamol Exposure

    Scientists tested the protective properties of dimethyl fumarate (DMF) before or after paracetamol exposure. Following DMF administration, Nrf2 nuclear translocation was tracked at the single-cell level and target gene transactivation confirmed.
    [iScience]

    AbstractGraphical Abstract

    mascRNA and Its Parent lncRNA MALAT1 Promote Proliferation and Metastasis of Hepatocellular Carcinoma Cells by Activating ERK/MAPK Signaling Pathway

    Using hepatocellular carcinoma cells as model, researchers found that MALAT1-associated small cytoplasmic RNA and its parent lncRNA MALAT1 could both promote cell proliferation, migration, and invasion in vitro.
    [Cell Death Discovery]

    Full Article

    Identification of Targets of JS-K against HBV-Positive Human Hepatocellular Carcinoma HepG2.2.15 Cells with iTRAQ Proteomics

    Molecular docking revealed the binding of JS-K to TAGLN and silenced Transgelin (shTAGLN)-2.15 cells were resistant to JS-K cytotoxicity, suggesting that TAGLN could be an important target in JS-K anti-HBV-positive liver cancer cells.
    [Scientific Reports]

    Full Article

    Drug-Drug Interaction between Metformin and Sorafenib Alters Antitumor Effect in Hepatocellular Carcinoma Cells

    In vitro experiments confirmed that pretreatment of different human hepatocellular carcinoma cell lines with metformin reduced the effects of sorafenib on cell viability, proliferation and signaling.
    [Molecular Pharmacology]

    Abstract

    UCP1 Governs Liver Extracellular Succinate and Inflammatory Pathogenesis

    Researchers identified an endocrine pathway regulated by uncoupling protein 1 (UCP1) that antagonized liver inflammation and pathology, independent of effects on obesity.
    [Nature Metabolism]

    Abstract

    Successful scientists are not just smart. They work smart.
    REVIEWS

    Immunobiology and Pathogenesis of Hepatitis B Virus Infection

    The authors review current knowledge on the immunobiology and pathogenesis of hepatitis B virus infection, focusing in particular on the role of CD8+ T cells and on several recent breakthroughs that challenge current dogmas.
    [Nature Reviews Immunology]

    Abstract

    Non-Alcoholic Fatty Liver Disease in Obese Children and Adolescents: A Role for Nutrition?

    Diet composition and in particular simple carbohydrate intake may promote the development of non-alcoholic fatty liver disease, whereas non-digestible carbohydrates, by affecting gut microbiota, may favor the integrity of gut wall and reduce inflammation, opposing this process.
    [European Journal of Clinical Nutrition]

    Abstract

    INDUSTRY AND POLICY NEWS

    Albireo Receives Positive CHMP Opinion for Bylvayâ„¢ (Odevixibat) for Treatment of Progressive Familial Intrahepatic Cholestasis (PFIC)

    Albireo Pharma, Inc. announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use issued a positive opinion recommending approval of Bylvay for the treatment of PFIC.
    [Albireo Pharma, Inc. (Globenews Wire, Inc.)]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells and Regenerative Medicine

    January 12 – 14, 2022
    Shanghai, China

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    JOB OPPORTUNITIES

    Bioinformatician – Genomics

    Deep Genomics, Inc. – Toronto, Ontario, Canada

    Assistant Professor – Drug Metabolism, Liver Disease

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    Postdoctoral Fellow – Fatty Liver and Diabetes

    Albert Einstein College of Medicine – Bronx, New York, United States

    Director – Liver Disease

    The Griffin Institute – Harrow, United Kingdom

    Postdoctoral Research Associate – Hepatitis B Virus Replication and Host Interactions

    University of Wisconsin-Madison – Madison, Wisconsin, United States

    > See All Jobs

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