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| Researchers reported that the zinc finger transcription factor Miz1 restricted hepatocyte-driven inflammation to suppress hepatocellular carcinoma, independently of its transcriptional activity.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The metastatic effects of exosomes derived from highly metastatic hepatocellular carcinoma cells were evaluated both in vitro and in vivo.
[Signal Transduction and Targeted Therapy] |
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| Scientists found that liver-specific knockout of pancreatic progenitor cell differentiation and proliferation factor (PPDPF) led to spontaneous fatty liver formation in a mouse model at 32 weeks of age on chow diets, which was enhanced by HFD.
[Nature Communications] |
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| In vitro and in vivo studies were performed in human hepatoma BCLC3 and Huh7 cells to analyze the effect of miR-518d-5p inhibition/overexpression during the response to sorafenib.
[Cell Death & Disease] |
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| Researchers explored the molecular mechanisms of PNO1 in hepatocellular carcinoma. Using 150 formalin-fixed and paraffin-embedded samples and 8 fresh samples, they found high PNO1 expression in hepatocellular carcinoma tumor tissues through Western blotting and RT-PCR.
[Cell Death & Disease] |
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| Live HepG2 cells were treated in normal glucose or high glucose medium and were measured directly using the FTIR approach.
[Biochimica Et Biophysica Acta-Molecular Cell Research] |
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| Scientists established liver fibrosis models using multicellular tumor spheroids composed of hepatocellular carcinoma and stromal cells such as fibroblasts, hepatic stellate cells, and endothelial cells seeded at constant ratios.
[Scientific Reports] |
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| Researchers assessed the influence of culture duration on the relative proteome abundance of HepG2 cells cultured as spheroids, which are routinely used to model aspects of the liver.
[Scientific Reports] |
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| Scientists investigated transcription profiles from peripheral blood mononuclear cells of 8 patients with hepatocellular carcinoma and PBMCs from co-culture model with hepatocellular carcinoma using RNA-Sequencing.
[Scientific Reports] |
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| Researchers mapped caQTLs in human liver tissue in 20 liver samples and identified 3,123 caQTLs.
[The American Journal of Human Genetics] |
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| The authors discuss the key advances in nanoparticles that have potential for liver cancer diagnosis and treatment. They also discuss the potential of nanoparticles to overcome the limitations of existing therapeutic modalities.
[Biomaterials Science] |
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| Investigator focus in particular on how infectious diseases, including coronavirus disease-19, hepatitis C, acquired immunodeficiency syndrome, peptic ulcer and periodontitis, exacerbate metabolic-associated fatty liver disease.
[Archives of Toxicology] |
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| Bavarian Nordic, Inc. has entered a partnership with Dynavax Technologies Corporation a biopharmaceutical company focused on developing and commercializing novel vaccines for the marketing and distribution of their HEPLISAV B® Hepatitis B vaccine in Germany with an expected launch in the fourth quarter of 2021.
[Bavarian Nordic, Inc. (Globenews Wire, Inc.)] |
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| PCI Biotech, Inc. a cancer focused biopharmaceutical company announced that the Ministry of Food and Drug Safety in South Korea has granted Orphan Drug Designation to its lead product candidate, fimaporfin, for combination treatment with gemcitabine in patients with inoperable locally advanced or metastatic bile duct cancer.
[PCI Biotech, Inc. (Globenews Wire, Inc.)] |
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| May 25 – 27, 2022
Hinxton, England, United Kingdom |
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| | Deep Genomics, Inc. – Toronto, Ontario, Canada |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | The Griffin Institute – Harrow, United Kingdom |
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| | Gilead Sciences, Inc. – Foster City, California, United States |
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