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| The proteomics studies on liver co-cultures implicated the activated hepatic stellate cells-secreted chemokine CXCL12 in the induction of natural killer (NK) cell quiescence through its cognate receptor CXCR4.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that fibroblast growth factor receptor 4 (FGFR4) was the most pivotal target in programmed death ligand 1 down-regulation by lenvatinib in vitro.
[Hepatology] |
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| Researchers found multifunction scaffold protein p54nrb/NONO exerted pleiotropic effects to regulate hypoxia transcription signals, thereby enhancing the progression of liver cancer.
[Oncogene] |
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| Scientists investigated if pterostilbene regulated glucose metabolism and insulin signaling, as well as its potential mechanism in the context of AGEs exposure.
[Molecular Nutrition & Food Research] |
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| Cell experiments have confirmed that reducing HSPA4 and HSPA14 expressions could inhibit the invasion, metastasis, and proliferation of hepatocellular carcinoma cells.
[Cancer Cell International] |
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| Scientists identified that TSN and RGF combination synergistically inhibited the proliferation and migration of MHCC-97L cells.
[Phytotherapy Research] |
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| Researchers employed lineage-tracing to demonstrate the tumorigenicity potential of the Pten–, SOX9+ cells. They showed that these cells were capable of giving rise to mixed-lineage tumors that manifested features of both hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
[Scientific Reports] |
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| Investigators described a study of a novel endogenous metabolic modulators composition comprising five amino acids and an amino acid derivative and its systematic evaluation across multiple nonalcoholic steatohepatitis-relevant primary human cell model systems, including hepatocytes, macrophages, and stellate cells.
[Scientific Reports] |
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| Scientists investigated the molecular mechanism and synergistic effect of anticancer properties of MH on Doxorubicin-mediated apoptotic cell death, using two different p53 statuses and one non-tumorigenic immortalized liver cell line.
[Biological Research] |
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| This review focuses on the role of microbiota in decompensation and strategies targeting microbiota to prevent acute decompensation.
[Journal of Hepatology] |
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| The authors describe the mechanisms of tissue repair following damage, highlighting the close relationship between inflammation and liver regeneration, and discuss how recent findings can help design novel therapeutic approaches.
[Nature Reviews Molecular Cell Biology] |
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| Boehringer Ingelheim and Zealand Pharma announced that the US FDA has granted Fast Track Designation to the GLP-1/glucagon dual agonist BI 456906 for adults with non-alcoholic steatohepatitis (NASH).
[Boehringer Ingelheim, Inc. (Globenews Wire, Inc.] |
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| Can-Fite BioPharma Ltd. announced that it has received clearance from the Israeli Ministry of Health to commence a Phase IIb study of its drug candidate Namodenoson in the treatment of non-alcoholic steatohepatitis (NASH).
[Can-Fite BioPharma Ltd.] |
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| June 14 – 18, 2021
Virtual |
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| | Oslo University Hospital – Oslo, Norway |
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| | Deep Genomics, Inc. – Toronto, Ontario, Canada |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | The Griffin Institute – Harrow, United Kingdom |
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| | Gilead Sciences, Inc. – Foster City, California, United States |
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