 | | Vol. 5.21 – 11 June, 2021 |
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| Scientists showed that the branched-chain fatty acids, isobutyric and isovaleric acid, increased glucose production and activated mTORC1/S6K1 in hepatocytes.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported the generation of a hepatobiliary tubular organoid using mouse hepatocyte progenitors and cholangiocytes.
[Nature Communications] |
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| Mechanistically, WSX1 transcriptionally downregulated an isoform of PI3K—PI3Kδ and thereby inactivated AKT, reducing AKT-induced GSK3β inhibition.
[Nature Communications] |
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| Researchers reported a new factor, CDCA2, in promoting hepatocellular carcinoma (HCC) development. CDCA2 amplification was reported as an independent risk factor for the recurrence and survival of HCC patients, which was positively correlated with elevated level of alpha-fetoprotein, high histological grade, large tumor size, advanced TNM stage, and poor prognosis for HCC patients.
[Oncogene] |
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| Scientists explored the role of CPSF4, for 3′ end formation and cleavage, in circRNA formation. Clinical research had shown that CPSF4 expression was upregulated in hepatocellular carcinoma (HCC) and that high expression of CPSF4 was associated with poor prognosis in HCC patients.
[Oncogene] |
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| Gain or loss-of-function studies indicated that the reduction of CircC16orf62 expression promoted the proliferation, invasion, and glycolysis of hepatocellular carcinoma in vitro and in vivo.
[Cell Death & Disease] |
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| Investigators reported the discovery of strong HNF4α agonists and their use to uncover a previously unknown pathway by which HNF4α controled the level of fat storage in the liver.
[Cell Death & Disease] |
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| Researchers demonstrated that Prostacyclin synthase (PTGIS) was downregulated in alcoholic liver disease and forced PTGIS expression in vivo using recombinant adeno-associated viral vector-packed PTGIS overexpression plasmid, which alleviated the inflammatory response and suppressed the classically activated macrophage phenotype in mice.
[Laboratory Investigation] |
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| To determine serum metabolites that were relevant and representative of the tissue status, scientists performed a two-step correlation analysis to first determine associations between metabolic genes and tissue metabolites, and second, between tissue metabolites and serum metabolites among 49 hepatocellular carcinoma (HCC) patients, which were then validated in 408 additional Asian HCC patients with mixed etiologies.
[Scientific Reports] |
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| In this review, the authors focus upon the microfibrillar collagen VI, which is present in the extracellular matrix of most tissues.
[FEBS Journal] |
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| Scientists present a compendium of studies evaluating the role of complement in human and murine models of associated liver disease.
[Immunology Letters] |
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| Gilead Sciences, Inc. announced that the US FDA has approved an expansion of the pediatric indication of Epclusa® for the treatment of chronic hepatitis C virus (HCV) to now include children as young as three years of age, regardless of HCV genotype or liver disease severity.
[Gilead Sciences, Inc.] |
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| June 21 – 24, 2021
Virtual |
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| | German Research Center for Environmental Health – Neuherberg, Germany |
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| | Oslo University Hospital – Oslo, Norway |
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| | Deep Genomics, Inc. – Toronto, Ontario, Canada |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Gilead Sciences, Inc. – Foster City, California, United States |
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