 | | Vol. 5.22 – 18 June, 2021 |
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| Researchers showed that restricted chromatin accessibility in intestinal stem cells prevented the expression of β-Catenin-regulated metabolic enzymes, whereas fine-tuning of WNT/β-Catenin activity by ZNRF3 and RNF43 restricted proliferation in chromatin-permissive AXIN2+ hepatocytes, while preserving metabolic function.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists used single-cell RNA sequencing analysis to delineate the immune landscape and tumor heterogeneity in a cohort of patients with HBV-associated human hepatocellular carcinoma.
[Nature Communications] |
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| Investigators identified a novel lncRNA, LINC01348, which was significantly downregulated in hepatocellular carcinoma (HCC) and correlated with survival functions in HCC patients.
[Oncogene] |
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| To dissect the mechanism of a combined tumoricidal therapeutic strategy, scientists investigated the scRNA-seq transcriptional profiles of an hepatocellular carcinoma xenograft following treatment.
[Journal of Nanobiotechnology] |
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| Ectopic expression of hepsin in cultured human hepatocytes and HEK293T cells suppressed the induction of IFNβ during viral infections by reducing the abundance of STING.
[Science Signaling] |
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| Scientists explored the genomics data of hepatocellular carcinoma, combined with literature analysis, in terms of the histone variant H2A.Z.
[Cell Death & Disease] |
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| Researchers selected highly expressed microRNAs with different read counts as candidate microRNAs and then tested whether the microRNAs were differentially expressed in hepatocellular carcinoma (HCC) tumor tissues, and they found that their expression was related to the HCC prognosis.
[Cell Death & Disease] |
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| The authors evaluated the expression of estrogen receptor alpha and its association with clinicopathological features in 339 hepatocellular carcinoma patients.
[Experimental & Molecular Medicine] |
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| Scientists demonstrated that oroxylin A, a natural product extracted from Scutellaria radix, significantly inhibited transforming growth factor-beta1-induced epithelial–mesenchymal transition and metastasis in hepatocellular carcinoma.
[Acta Pharmacologica Sinica] |
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| Researchers investigated the effects of bile acids on tissue factor activity and thrombin generation in hepatocytes and correlated these effects with activation of farnesoid X receptor-dependent signaling and apoptosis.
[Laboratory Investigation] |
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| Using next-generation and Sanger sequencing investigators found that, p53 in Hep3B cells was impaired by TP53-FXR2 fusion, and that overexpression of the C19MC miRNA-520G in Hep3B cells promoted the expression of MAGEA-3, 6 and 12 mRNAs.
[Scientific Reports] |
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| Scientists discuss how anti-fibrotic therapies have progressed over the years, and how nanomedicine formulations can potentiate anti-fibrotic treatment efficacy.
[Advanced Drug Delivery Reviews] |
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| The authors summarize the formation strategies and a wide range of applications in biomedicine of liver organoid.
[Tissue Engineering and Regenerative Medicine] |
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| Can-Fite BioPharma Ltd. announced the Chinese National Intellectual Property Administration has issued a Notice of Allowance for its patent titled “An A3 Adenosine Receptor Ligand for Use in Treating Ectopic Fat Accumulation”. .
[Can-Fite BioPharma Ltd.] |
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| InSphero AG, officially launched a pre-competitive consortium that brought together representatives from pharmaceutical companies engaged and invested in the development of cross-species drug testing and validation strategies for rapid, reliable drug-testing of drug-induced liver injury and translation to humans.
[InSphero AG] |
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| May 11 – 14, 2022
Sant Feliu de Guixols, Spain |
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| Massachusetts General Hospital – Boston, Massachusetts, United States |
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| German Research Center for Environmental Health – Neuherberg, Germany |
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| Oslo University Hospital – Oslo, Norway |
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| University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| Gilead Sciences, Inc. – Foster City, California, United States |
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