 | | Vol. 5.23 – 25 June, 2021 |
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| Researchers identified that increased expression of the Notch ligand Jagged1 tracked with Notch activation and nonalcoholic fatty liver disease activity score in human liver biopsy specimens and mouse NASH models.
[Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists used a temporally restricted model of hepatic repair in which large-scale hepatocyte injury and regeneration were initiated through the acute loss of Mdm2 in hepatocytes, resulting in the rapid, coordinated proliferation of biliary epithelial cells.
[Science Signaling] |
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| Investigators showed that clinical-stage orally administered drugs that antagonized the function of cellular inhibitor of apoptosis proteins can eliminate HBV replication and episomal HBV genome in the liver.
[Cell Death & Disease] |
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| The authors showed that monocyte/macrophage CD11B mRNA levels were increased significantly in livers of biliary atresia patients and positively correlated with the progression of liver inflammation and fibrosis.
[Cell Death & Disease] |
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| Researchers found that hepatocytes from a mammalian hibernator, the Syrian hamster, exhibited remarkable resistance to prolonged cold culture, whereas murine hepatocytes underwent cold-induced cell death that fulfilled the hallmarks of ferroptosis.
[Communications Biology] |
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| Few syngeneic mouse models of liver cancer are available. Scientists established liver tumor cell lines from hepatitis C virus transgenic mice fed an atherogenic high-fat diet.
[Scientific Reports] |
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| Investigators evaluated the effects of L-carnitine supplementation on mitochondrial damage and other hepatocyte injuries following severe burns and the related mechanisms.
[Nutrition & Metabolism] |
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| Scientists screened stem cells in primary liver cancer cells, analyzed their biological characteristics and proposed the possibility that liver cancer originated from stem cells.
[Clinical & Translational Oncology] |
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| Immunostaining was performed using liver sections of Caroli disease and polycystic liver disease, and the results were compared with those of congenital hepatic fibrosis and von Meyenburg complex.
[Pathology International] |
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| The authors describe how functional screens can help to deepen our understanding of liver cancer and guide the development of new therapeutic strategies.
[Nature Reviews Gastroenterology & Hepatology] |
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| Scientists review the combination of lenvatinib plus pembrolizumab for the treatment of advanced hepatocellular carcinoma.
[Expert Opinion On Investigational Drugs] |
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| Dicerna Pharmaceuticals, Inc. announced it has initiated patient dosing in the Company’s Phase II ESTRELLA trial of belcesiran, an investigational GalXC™ RNAi therapeutic candidate for the treatment of alpha-1 antitrypsin deficiency-associated liver disease.
[Dicerna Pharmaceuticals, Inc.] |
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| Terns Pharmaceuticals, Inc. announced the initiation of patient dosing in the AVIATION Trial, a Phase Ib clinical trial evaluating TERN-201, an orally-administered, highly selective inhibitor of vascular adhesion protein-1 (VAP-1) in patients with non-alcoholic steatohepatitis.
[Terns Pharmaceuticals, Inc.] |
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| November 29 – December 1, 2021
Barcelona, Spain |
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| University of Southern Denmark – Odense, Denmark |
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| Massachusetts General Hospital – Boston, Massachusetts, United States |
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| German Research Center for Environmental Health – Neuherberg, Germany |
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| University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| Gilead Sciences, Inc. – Foster City, California, United States |
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