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| Scientists revealed that the transcriptional dynamics of circulating tumor cells were associated with stress response, cell cycle and immune-evasion signaling during hematogeneous transportation.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers established that hepatocyte depolarization depressed hepatic afferent vagal nerve firing, increased GABA release from liver slices, and caused hyperinsulinemia.
[Cell Reports] |
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| Scientists investigated the metabolic characteristics of dendrobine in vitro and in rats. The metabolic stability and temporal profile of metabolites formation of dendrobine were assayed in human/rat liver microsomal and S9 fractions.
[Acta Pharmacologica Sinica] |
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| Researchers demonstrated that CDK9 was closely associated with the progression of hepatocellular carcinoma (HCC) and could serve as an HCC therapeutic target by modulating the recovery of wild-type p53 function.
[Acta Pharmacologica Sinica] |
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| Differentiation of organoids significantly increased the expression of multiple cytochrome P450, phase II enzymes, liver biomarkers and hepatic transporters. The differentiated organoids were shown to exhibit increased sensitivity to midazolam and irinotecan, when compared to the undifferentiated organoids.
[Archives of Toxicology] |
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| Investigators utilized four common hepatocellular carcinoma (HCC) cell lines embedded in 3D collagen type-I gels of varying stiffnesses to mimic normal and cirrhotic livers with environmental oxygen regulation to quantify the impact of these microenvironmental factors on HCC chemoresistance.
[Frontiers in Oncology] |
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| The antifibrotic effect of auranofin was assessed in thioacetamide- and carbon tetrachloride-induced liver fibrosis models. Hepatic stellate cells, bone marrow-derived macrophages, kupffer cells, and hepatocyte were used to examine the underlying mechanism of auranofin.
[Communications Biology] |
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| Researchers clarified the intestinal absorption kinetics of dietary palmitic acid (PA) and the effect of trans-portal PA on the activation of hepatic stellate cells involved in liver fibrosis in nonalcoholic steatohepatitis.
[Scientific Reports] |
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| Investigators developed a human-on-a-chip model composed of human hepatocytes and adipose tissue chambers capable of modeling the metabolic factors that contribute to liver disease development and progression, and evaluation of the therapeutic metformin.
[Scientific Reports] |
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| The authors evaluate the efficacy and safety of radioembolization plus sorafenib in hepatocellular carcinoma patients.
[Digestive and Liver Disease] |
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| The authors review the various molecular pathways, and genetic relevance of mRNA expression of fetuin-A which is correlated with progression of non-alcoholic fatty liver disease (NAFLD).
[inflammopharmacology] |
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| Axcella Health, Inc. announced that it has activated initial clinical sites and patient screening for its global Phase II clinical trial of AXA1665, the company’s multi-targeted oral product candidate for the reduction in risk of recurrent overt hepatic encephalopathy.
[Axcella Health, Inc.] |
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| Sirnaomics, Inc. has announced dose administration for the first patient in a Phase I US clinical study for liver cancer treatment, with the company’s small interfering RNA drug candidate, STP705.
[Sirnaomics, Inc.] |
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| January 12 – 14, 2022
Shanghai, China |
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| University of Minnesota – Austin, Minnesota, United States |
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| University of Southern Denmark – Odense, Denmark |
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| Massachusetts General Hospital – Boston, Massachusetts, United States |
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| German Research Center for Environmental Health – Neuherberg, Germany |
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| Gilead Sciences, Inc. – Foster City, California, United States |
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